Patent US3896157A successfully refreshed from Google Patents.
US3896157A
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Dihydo 2-naphthylacetic acid derivatives
Assignee: Syntex Pharmaceuticals International Ltd
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Filing: 1971-11-04
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Granted: 1975-07-22
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Expires: 1991-11-04
Abstract
Abstract 2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the Alpha -position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturated at positions 3 and 4, are anti-inflammatory, analgesic, anti-pyretic and anti-pruritic agents. A pharmaceutical method of effecting treatment of inflammation, pain, pyrexia and pruritus by the administration of naphthyl acetic acid derivatives. A pharmaceutical composition for use in the treatment of the above maladies comprising a naphthyl acetic acid derivative.
Inventors
- 👤 John H Fried
- 👤 Ian T Harrison
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 01:47
CPC Classifications
C; C07; C07C; C07C323/00; C07C45/00; C07C45/27; C07C45/28; C07C45/45; C07C45/46; C07C49/00; C07C49/587; C07C49/687; C07C49/697; C07C49/753; C07C49/755; C07C49/76; C07C49/84; C07C57/00; C07C57/52; C07C57/58; C07C59/00; C07C59/40; C07C59/58; C07C59/72; C07C59/76; C07C59/88; C07D; C07D307/00; C07D307/02; C07D307/04; C07D307/18; C07D307/20
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
31 words
A COMPOUND SELECTED FROM THE GROUP CONSISTING OF 3,4DIHYDRO-6-FLUORO-2-NAPHTHYL-A-METHYLACETIC ACID, THE ALKYL ESTERS THEREOF WHEREIN THE ALKYL MOIETY HAS 1 TO 12 CARBON ATOMS, AND THE PHARMACEUTICALLY ACCEPTABLE ADDITION SALTS THEREOF.
Claim 2
Dependent Claim
31 words
A COMPOUND SELECTED FROM THE GROUP CONSISTING OF 3,4DIHYDRO-6-FLUORO-2-NAPHTHYL-A-METHYLACETIC ACID, THE ALKYL ESTERS THEREOF WHEREIN THE ALKYL MOIETY HAS 1 TO 12 CARBON ATOMS, AND THE PHARMACEUTICALLY ACCEPTABLE ADDITION SALTS THEREOF.
Claim 3
Dependent Claim
33 words
A compound selected from the group consisting of 3,4-dihydro-6-chloro-2-naphthyl- Alpha -methylacetic acid, the alkyl esters thereof wherein the alkyl moiety has 1 to 12 carbon atoms, and the pharmaceutically acceptable addition salts thereof.
Claim 4
Dependent Claim
33 words
A compound selected from the group consisting of 3,4-dihydro-6-chloro-2-naphthyl- Alpha -methylacetic acid, the alkyl esters thereof wherein the alkyl moiety has 1 to 12 carbon atoms, and the pharmaceutically acceptable addition salts thereof.
Claim 5
Dependent Claim
33 words
A compound selected from the group consisting of 3,4-dihydro-6-methyl-2-naphthyl- Alpha -methylacetic acid, the alkyl esters thereof wherein the alkyl moiety has 1 to 12 carbon atoms, and the pharmaceutically acceptable addition salts thereof.
Claim 6
Dependent Claim
33 words
A compound selected from the group consisting of 3,4-dihydro-6-methyl-2-naphthyl- Alpha -methylacetic acid, the alkyl esters thereof wherein the alkyl moiety has 1 to 12 carbon atoms, and the pharmaceutically acceptable addition salts thereof.
Claim 7
Dependent Claim
33 words
A compound selected from the group consisting of 3,4-dihydro-6-trifluoromethyl-2-naphthyl- Alpha -methylacetic acid, the alkyl esters thereof wherein the alkyl moiety has 1 to 12 carbon atoms, and the pharmaceutically acceptable addition salts thereof.
Claim 8
Dependent Claim
33 words
A compound selected from the group consisting of 3,4-dihydro-6-trifluoromethyl-2-naphthyl- Alpha -methylacetic acid, the alkyl esters thereof wherein the alkyl moiety has 1 to 12 carbon atoms, and the pharmaceutically acceptable addition salts thereof.
Claim 9
Dependent Claim
33 words
A compound selected from the group consisting of 3,4-dihydro-6-methoxy-2-naphthyl- Alpha -methylacetic acid, the alkyl esters thereof wherein the alkyl moiety has 1 to 12 carbon atoms, and the pharmaceutically acceptable addition salts thereof.
Claim 10
Dependent Claim
33 words
A compound selected from the group consisting of 3,4-dihydro-6-methoxy-2-naphthyl- Alpha -methylacetic acid, the alkyl esters thereof wherein the alkyl moiety has 1 to 12 carbon atoms, and the pharmaceutically acceptable addition salts thereof.
Claim 11
Dependent Claim
31 words
A COMPOUND SELECTED FROM THE GROUP CONSISTING OF 3,4DIHYDRO-6-METHYLTHIO-2-NAPHTHYL-A-METHYLACETIC ACID, THE ALKYL ESTERS THEREOF WHEREIN THE ALKYL MOIETY HAS 1 TO 12 CARBON ATOMS, AND THE PHARMACEUTICALLY ACDEPTABLE ADDITION SALTS THEREOF.
Claim 12
Dependent Claim
31 words
A COMPOUND SELECTED FROM THE GROUP CONSISTING OF 3,4DIHYDRO-6-METHYLTHIO-2-NAPHTHYL-A-METHYLACETIC ACID, THE ALKYL ESTERS THEREOF WHEREIN THE ALKYL MOIETY HAS 1 TO 12 CARBON ATOMS, AND THE PHARMACEUTICALLY ACDEPTABLE ADDITION SALTS THEREOF.
References Cited (Backward Citations)
US3334096A
Cited
US3506671A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-07-21 | 1979-01-20 | 1979-07-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-07-21 | 1983-01-20 | 1983-07-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-07-21 | 1987-01-20 | 1987-07-22 | $7700.00 | Window Closed / Lapsed |