Patent US3893993A successfully refreshed from Google Patents.
US3893993A
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Allergenic extracts cross linked under acid conditions with inorganic cyanates
Assignee: Beecham Group PLC
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Filing: 1973-07-20
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Granted: 1975-07-08
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Expires: 1993-07-20
Abstract
Abstract Desensitizing or immunizing agents are provided for treating hypersensitive or allergic conditions. Modified allergenic material is prepared comprising an allergenic protein or glycoprotein crosslinked intermolecularly or intramolecularly with an inorganic cyanate. The modified material has reduced allergenicity relative to the uncrosslinked allergen and has the ability to produce antibodies having cross-specificity for the uncrosslinked allergenic protein or glycoprotein.
Inventors
- 👤 Noel Austin Mullan
- 👤 Brian George Overell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 14:18
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/35; A61K39/36; A61K2039/60; A61K2039/6012; Y; Y10; Y10S; Y10S530/00; Y10S530/806
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
131 words
A PROCESS FOR THE PREPARATION OF A MODIFIED ALLERGENIC MATERIAL WHICH COMPRISES AN ALLERGENIC EXTRACT TO POLLEN OR HOUSE DUST WHICH CONSISTS PRINCIPALLY OF A PROTEIN OR GLYCOPROTEIN, WHICH ALLERGENIC EXTRACT IS CROSSLINKED UNDER ACIDIC CONDITIONS INTER- OR INTRA-MOLECULARLY WITH AN INORGANIC CYANATE, SAID MODIFIED ALLERGENIC MATERIAL BEING SUBSTANTIALLY WATERINSOLUBLE OR ONLY SPARINGLY WATER-SOLUBLE AND HAVING A REDUCED ALLERGENICITY RELATIVE TO THE UNCROSSLINKED PROTEIN OR GLYCOPROTEIN AND HAVING THE ABILITY TO STIMULATE THE PRODUCTION OF ANTIBODIES HAVING CROSS-SPECIFICIY FOR THE UNLINDED PROTEIN OR GLYCOPROTEIN, WHICH COMPRISES REACTING AN ALLERGENIC EXTRACT OF A POLLEN EXTRACT SELECTED FROM THE GROUP CONSISTING OF COCKSFOOT POLLEN, MIXED GROSS POLLENS AND TIMOTHY POLLEN OR HOUSE DUST WITH AN INORGANIC CYANATE AT AN ACIDIC PH TO REDUCE THE ALLERGENICITY AND RECOVERING THE MODIFIED ALLERGENIC MATERIAL SO PRODUCED.
Claim 2
Dependent Claim
131 words
A PROCESS FOR THE PREPARATION OF A MODIFIED ALLERGENIC MATERIAL WHICH COMPRISES AN ALLERGENIC EXTRACT TO POLLEN OR HOUSE DUST WHICH CONSISTS PRINCIPALLY OF A PROTEIN OR GLYCOPROTEIN, WHICH ALLERGENIC EXTRACT IS CROSSLINKED UNDER ACIDIC CONDITIONS INTER- OR INTRA-MOLECULARLY WITH AN INORGANIC CYANATE, SAID MODIFIED ALLERGENIC MATERIAL BEING SUBSTANTIALLY WATERINSOLUBLE OR ONLY SPARINGLY WATER-SOLUBLE AND HAVING A REDUCED ALLERGENICITY RELATIVE TO THE UNCROSSLINKED PROTEIN OR GLYCOPROTEIN AND HAVING THE ABILITY TO STIMULATE THE PRODUCTION OF ANTIBODIES HAVING CROSS-SPECIFICIY FOR THE UNLINDED PROTEIN OR GLYCOPROTEIN, WHICH COMPRISES REACTING AN ALLERGENIC EXTRACT OF A POLLEN EXTRACT SELECTED FROM THE GROUP CONSISTING OF COCKSFOOT POLLEN, MIXED GROSS POLLENS AND TIMOTHY POLLEN OR HOUSE DUST WITH AN INORGANIC CYANATE AT AN ACIDIC PH TO REDUCE THE ALLERGENICITY AND RECOVERING THE MODIFIED ALLERGENIC MATERIAL SO PRODUCED.
Claim 3
Dependent Claim
13 words
A process according to claim 1 wherein the temperature is below 100* C.
Claim 4
Dependent Claim
12 words
A process according to claim 1 wherein the pH is about 5.
Claim 5
Dependent Claim
13 words
A process according to claim 2 wherein the temperature is about room temperature.
Claim 6
Dependent Claim
21 words
A process according to claim 1 wherein the inorganic cyanate is an alkali metal cyanate or an alkaline earth metal cyanate.
Claim 7
Dependent Claim
13 words
A process according to claim 1 wherein the inorganic cyanate is potassium cyanate.
Claim 8
Dependent Claim
14 words
A process according to claim 1 wherein the allergenic extract is a pollen extract.
Claim 9
Dependent Claim
15 words
A process according to claim 1 wherein the allergenic extract is a house dust extract.
Claim 10
Dependent Claim
78 words
A modified allergenic material which comprises an allergenic extract of pollen or house dust which consists principally of a protein or glycoprotein, which allergenic extract is crosslinked under acidic conditions inter- or intramolecularly with an inorganic cyanate, said modified allergenic material being substantially water-insoluble or only sparingly water-soluble and having a reduced allergenicity relative to the uncrosslinked protein or glycoprotein and having the ability to stimulate the production of antibodies having cross-specificity for the unlinked protein or glycoprotein.
Claim 11
Dependent Claim
78 words
A modified allergenic material which comprises an allergenic extract of pollen or house dust which consists principally of a protein or glycoprotein, which allergenic extract is crosslinked under acidic conditions inter- or intramolecularly with an inorganic cyanate, said modified allergenic material being substantially water-insoluble or only sparingly water-soluble and having a reduced allergenicity relative to the uncrosslinked protein or glycoprotein and having the ability to stimulate the production of antibodies having cross-specificity for the unlinked protein or glycoprotein.
Claim 12
Dependent Claim
16 words
A modified allergenic material according to claim 9 wherein the allergenic extract is a pollen extract.
Claim 13
Dependent Claim
17 words
A modified allergenic material according to claim 9 wherein the allergenic extract is a house dust extract.
Claim 14
Dependent Claim
23 words
A modified allergenic material according to claim 9 wherein the inorganic cyanate is an alkali metal cyanate or an alkaline earth metal cyanate.
Claim 15
Dependent Claim
15 words
A modified allergenic material according to claim 9 wherein the inorganic cyanate is potassium cyanate.
Claim 16
Dependent Claim
14 words
A modified allergenic material according to claim 10 wherein the pollen is Cocksfoot pollen.
Claim 17
Dependent Claim
15 words
A modified allergenic material according to claim 10 wherein the pollen is mixed grass pollens.
Claim 18
Dependent Claim
14 words
A modified allergenic material according to claim 10 wherein the pollen is timothy polLen.
References Cited (Backward Citations)
US2816099A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-07-07 | 1979-01-06 | 1979-07-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-07-07 | 1983-01-06 | 1983-07-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-07-07 | 1987-01-06 | 1987-07-08 | $7700.00 | Window Closed / Lapsed |