Patent US3893447A successfully refreshed from Google Patents.
US3893447A
Expired / Lapsed
US
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Simultaneous angiography of the separate retinal and choroidal circulations
Assignee: Johns Hopkins University
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Filing: 1973-06-04
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Granted: 1975-07-08
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Expires: 1993-06-04
Abstract
Abstract Simultaneous angiography of the separate retinal and choroidal circulations of the human eye is accomplished following a single intravenous injection of a mixture of at least two dyes having differing spectral characteristics. In a preferred embodiment of the invention, a single injection of a mixture of sodium fluorescein and indocyanine green dyes is administered intravenously to the subject. Angiograms of the separate retinal and choroidal circulations are then taken simultaneously with a fundus camera modified to separate the electromagnetic radiation emanating from the eye which is respectively attributable to the sodium fluorescein dye and to the indocyanine green dye.
Inventors
- 👤 Bernard F Hochheimer
- 👤 Robert W Flower
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 04:33
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/1455; A61B5/14551; A61B5/14555; A61B3/00; A61B3/10; A61B3/12; A61B3/1241
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
82 words
A method for the simultaneous angiography of the separate retinal and choroidal circulations of the eye, comprising the steps of: injecting a mixture of substances into the circulatory blood system of the human body, the substances of the mixture transmitting electromagnetic radiation in different portions of the electromagnetic spectrum; irradiating the eye with electromagnetic radiation; splitting the electromagnetic radiation transmitted from the eye into at least two components having different wavelength ranges; and, recording the separate radiation components independently of each other.
Claim 2
Independent Claim
82 words
A method for the simultaneous angiography of the separate retinal and choroidal circulations of the eye, comprising the steps of: injecting a mixture of substances into the circulatory blood system of the human body, the substances of the mixture transmitting electromagnetic radiation in different portions of the electromagnetic spectrum; irradiating the eye with electromagnetic radiation; splitting the electromagnetic radiation transmitted from the eye into at least two components having different wavelength ranges; and, recording the separate radiation components independently of each other.
Claim 3
Dependent Claim
46 words
The method of claim 1 wherein the mixture of substances comprises a first substance which transmits electromagnetic radiation in the visible portion of the spectrum on irradiation thereof and a second substance which transmits electromagnetic radiation in the infrared portion of the spectrum on irradiation thereof.
Claim 4
Dependent Claim
18 words
The method of claim 1 wherein the mixture of substances comprises sodium fluorescein dye and indocyanine green dye.
Claim 5
Dependent Claim
57 words
The method of claim 3 wherein the electromagnetic radiation transmitted from the eye is split into a first component in the visible portion of the spectrum which corresponds to the emission spectra of sodium fluorescein dye and a second component in the infrared portion of the spectrum which corresponds to the absorption spectra of indocyanine green dye.
Claim 6
Dependent Claim
70 words
The method of claim 4 wherein said first component is recorded at predetermined temporal intervals by a first camera using film sensitive to visible radiation for recording the filling of the retinal circulation of the eye and wherein said second component is simultaneously recorded at the same temporal intervals by a second camera using film sensitive to infrared radiation for recording the filling of the choroidal circulation of the eye.
Claim 7
Dependent Claim
37 words
The method of claim 4 wherein the electromagnetic radiation transmitted from the eye is further split into a third component in the infrared portion of the spectrum which corresponds to the emission spectra of indocyanine green dye.
Claim 8
Dependent Claim
108 words
The method of claim 6 wherein said first component is recorded at predetermined temporal intervals by a first camera using film sensitive to visible radiation for recording the filling of the retinal circulation of the eye, wherein said second component is simultaneously recorded at the same temporal intervals by a second camera using film sensitive to infrared radiation for recording the filling of the larger vessels of the choroidal circulation of the eye, and wherein said third component is simultaneously recorded at the same temporal intervals by a third camera using film sensitive to infrared radiation for recording the smaller vessels of the choroidal circulation of the eye.
Claim 9
Dependent Claim
84 words
Apparatus for simultaneously producing angiograms of the separate retinal and choroidal circulations of the eye, comprising: flash means for irradiating the eye with electromagnetic radiation; filter means for removing electromagnetic radiation in the wavelength ranges of 500 to 700nm and above 800nm respectively prior to entry of said radiation in to the eye; beam splitting means for separating the electromagnetiC radiation emanating from the eye after irradiation thereof into at least two components having different wavelength ranges; and, means for separately recording said components.
Claim 10
Dependent Claim
84 words
Apparatus for simultaneously producing angiograms of the separate retinal and choroidal circulations of the eye, comprising: flash means for irradiating the eye with electromagnetic radiation; filter means for removing electromagnetic radiation in the wavelength ranges of 500 to 700nm and above 800nm respectively prior to entry of said radiation in to the eye; beam splitting means for separating the electromagnetiC radiation emanating from the eye after irradiation thereof into at least two components having different wavelength ranges; and, means for separately recording said components.
Claim 11
Dependent Claim
43 words
The apparatus of claim 8 and further comprising means for separating the electromagnetic radiation in the wavelength range above 500 nm emanating from the eye into two separate components having respective wavelength ranges of between 500 to 700 nm and above 700 nm.
Claim 12
Dependent Claim
37 words
The apparatus of claim 9 and further comprising filter means for removing electromagnetic radiation from the component lying in the wavelength range above 700 nm all radiation except that radiation in a narrow band around 800 nm.
Claim 13
Dependent Claim
119 words
Apparatus for simultaneously producing angiograms of the separate retinal and choroidal circulations of the eye, comprising: flash means for irradiating the eye with electromagnetic radiation; beam splitting means for separating the electromagnetic radiation emanating from the eye after irradiation thereof into components having different wavelength ranges, the beam splitting means comprising at least two optical separation devices, a first device separating the electromagnetic radiation emanating from the eye into two components, a first component having a wavelength range between 500 to 600nm and a second component having a wavelength range above 700nm, and a second device separating said second component into component beams of wavelengths greater than and less than 800nm respectively; and means for seperately recording said components.
Claim 14
Dependent Claim
119 words
Apparatus for simultaneously producing angiograms of the separate retinal and choroidal circulations of the eye, comprising: flash means for irradiating the eye with electromagnetic radiation; beam splitting means for separating the electromagnetic radiation emanating from the eye after irradiation thereof into components having different wavelength ranges, the beam splitting means comprising at least two optical separation devices, a first device separating the electromagnetic radiation emanating from the eye into two components, a first component having a wavelength range between 500 to 600nm and a second component having a wavelength range above 700nm, and a second device separating said second component into component beams of wavelengths greater than and less than 800nm respectively; and means for seperately recording said components.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-07-07 | 1979-01-06 | 1979-07-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-07-07 | 1983-01-06 | 1983-07-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-07-07 | 1987-01-06 | 1987-07-08 | $7700.00 | Window Closed / Lapsed |