Abstract Improved method and means for packaging multi-container biological, medical and pharmaceutical substances where shelf life demands small active ingredient bottle and large diluent bottle; improved storage, shipping and merchandising container for a pair of different sized bottles where one contains liquid; compartmented packaging for multiple bottle set where space is at a premium and immobility of containers or bottles within the package is desired; dimensioned packaging for receiving and stably positioning two bottles of markedly different size and typically different contents in a minimum space; an improved packaging blank having a lower larger component for vertical storage of a liquid-containing bottle and an upper compartment with bottle-receiving platform for horizontal storage of a solidcontaining bottle, the two bottles so sized as to permit preparation of varying dosage levels or quantities in a specific case; improved method of dispensing biologicals such as viruses, wherein the freeze-dried virus is received within a minimum size bottle or container adequate to thereafter receive sufficient liquid diluent to dissolve all said freezer-dried virus cake, the diluent liquid received in a second, larger size bottle or container, the virus cake within the smaller said bottle which is transferred out of same dissolved in the diluent being sufficient to meet the minimum Government requirements for viral content when reconstituted with the entire quantity of diluent liquid in the accompanying second larger bottle, the second, larger diluent bottle so sized that it can receive both the maximum quantity of diluent to remain within the Government requirements for viral content when reconstituted and lesser quantities of said diluent.
A method of separately sub-packaging freeze-dried virus cake and the diluent therefor in a common package for later reconstitution of the virus cake and diluent by mixing same together comprising the steps of: packaging the freeze-dried virus cake within a first relatively smaller bottle, the quantity of virus cake in the first bottle such and the first bottle sized substantially no larger than that a single filling of the first bottle with diluent will dissolve the entire virus cake therein for transfer thereof to said second bottle, packaging the diluent in a second relatively larger size bottle, said diluent operative to reconstitute the virus cake for use when mixed therewith, the largest quantity of diluent receivable in the second bottle such and the second bottle so sized, that, when the virus cake in the first bottle is dissolved therein, the resultant solution meets the Government requirement for minimum viral quantity in use, said first and second bottles packaged together in a third disposable container for ultimate use and application by a further step wherein, after removal of said first and second bottles from the said third containers, a single quantity of diluent is transferred in a single batch from the said second larger bottle to said first smaller bottle thereby to dissolve all of the freeze-dried virus cake therein and thereafter the said completely dissolved viral fluids, in diluent, are transferred back to said second relatively larger bottle in a single batch to provide in said second bottle a properly proportioned and concentrated virus solution.
Claim 2
Independent Claim
255 words
A method of separately sub-packaging freeze-dried virus cake and the diluent therefor in a common package for later reconstitution of the virus cake and diluent by mixing same together comprising the steps of: packaging the freeze-dried virus cake within a first relatively smaller bottle, the quantity of virus cake in the first bottle such and the first bottle sized substantially no larger than that a single filling of the first bottle with diluent will dissolve the entire virus cake therein for transfer thereof to said second bottle, packaging the diluent in a second relatively larger size bottle, said diluent operative to reconstitute the virus cake for use when mixed therewith, the largest quantity of diluent receivable in the second bottle such and the second bottle so sized, that, when the virus cake in the first bottle is dissolved therein, the resultant solution meets the Government requirement for minimum viral quantity in use, said first and second bottles packaged together in a third disposable container for ultimate use and application by a further step wherein, after removal of said first and second bottles from the said third containers, a single quantity of diluent is transferred in a single batch from the said second larger bottle to said first smaller bottle thereby to dissolve all of the freeze-dried virus cake therein and thereafter the said completely dissolved viral fluids, in diluent, are transferred back to said second relatively larger bottle in a single batch to provide in said second bottle a properly proportioned and concentrated virus solution.
Claim 3
Dependent Claim
43 words
A method as in claim 1 wherein the diluent bottle is initially substantially filled with said diluent whereby the ultimately reconstituted virus solution in the diluent bottle is at essentially a concentration equal to the government requirement for minimum viral quantity in use.
Claim 4
Dependent Claim
46 words
A method as in claim 1 wherein the said diluent bottle is initially substantially less than filled with said diluent, whereby the ultimately reconstituted virus solution in the diluent bottle is at a concentration substantially greater than the Government requirement for minimum viral quantity in use.