Patent US3891616A successfully refreshed from Google Patents.
US3891616A
Expired / Lapsed
US
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Hypotensive {62 -homoaminoacid nonapeptides
Assignee: ER Squibb and Sons LLC
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Filing: 1974-04-17
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Granted: 1975-06-24
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Expires: 1994-04-17
Abstract
Abstract Peptides of the formula Arg-A-Pro-Gly-B-Ser-A-B-Arg wherein A is Pro or Beta H-Pro and B is Phe or Beta H-Phe, provided at least one A or B is a Beta -homoaminoacid, possess hypotensive activity and are more resistant to enzymatic degradation than the corresponding Alpha -aminoacid peptide.
Inventors
- 👤 Miguel Angel Ondetti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 14:56
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/04; C07D207/08; C07K; C07K7/00; C07K7/04; C07K7/18; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S530/00; Y10S530/80
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
45 words
A NONAPERPIDE OF THE FORMULA ARG-A-PRO-GLY-B-SER-AB-ARG WHEREIN A IS PRO OR BH-PRO AND B IS PHE OR BH-PHE, WHEREIN BH-PRO REPRESENTS B-HOMOPROLINE AND BH-PHE REPRESENTS B-HOMOPHENYLANINE, PROVIDED AT LEAST ONE OF A OR B IS A B-HOMOAMINOACID. ALL AMINO ACIDS THEREOF BEING OF THE CONFIGURATION.
Claim 2
Dependent Claim
45 words
A NONAPERPIDE OF THE FORMULA ARG-A-PRO-GLY-B-SER-AB-ARG WHEREIN A IS PRO OR BH-PRO AND B IS PHE OR BH-PHE, WHEREIN BH-PRO REPRESENTS B-HOMOPROLINE AND BH-PHE REPRESENTS B-HOMOPHENYLANINE, PROVIDED AT LEAST ONE OF A OR B IS A B-HOMOAMINOACID. ALL AMINO ACIDS THEREOF BEING OF THE CONFIGURATION.
Claim 3
Dependent Claim
91 words
A nonapeptide according to claim 1 having the amino acid sequence Arg-Pro-Pro-Gly-Phe-Ser-Pro- Beta H-Phe-Arg, Arg-Pro-Pro-Gly-Phe-Ser- Beta H-Pro- Beta H-Phe-Arg, Arg-Pro-Pro-Gly-Phe-Ser- Beta H-Pro-Phe-Arg, Arg-Pro-Pro-Gly- Beta H-Phe-Ser-Pro-Phe-Arg, Arg-Pro-Pro-Gly- Beta H-Phe-Ser-Pro- Beta H-Phe-Arg, Arg-Pro-Pro-Gly- Beta H-Phe-Ser- Beta H-Pro- Beta H-Phe-Arg, Arg-Pro-Pro-Gly- Beta H-Phe-Ser- Beta H-Pro-Phe-Arg, Arg- Beta H-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg, Arg- Beta H-Pro-Pro-Gly-Phe-Ser-Pro- Beta H-Phe-Arg, Arg- Beta H-Pro-Pro-Gly-Phe-Ser- Beta H-Pro- Beta H-Phe-Arg, Arg- Beta H-Pro-Pro-Gly-Phe-Ser- Beta H-Pro-Phe-Arg, Arg- Beta H-Pro-Pro-Gly- Beta H-Phe-Ser-Pro-Phe-Arg, Arg- Beta H-Pro-Pro-Gly- Beta H-Phe-Ser-Pro- Beta -H-Phe-Arg, Arg- Beta H-Pro-Pro-Gly- Beta H-Phe-Ser- Beta H-Pro- Beta H-Phe-Arg or Arg- Beta H-Pro-Pro-Gly- Beta H-Phe-Ser- Beta H-Pro-Phe-Arg.
Claim 4
Dependent Claim
18 words
A nonapeptide according to claim 1 having the amino acid sequence Arg-Pro-Pro-Gly-Phe-Ser-Pro- Beta H-Phe-Arg or Arg-Pro-Pro-Gly-Phe-Ser- Beta H-Pro-Phe-Arg.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-06-23 | 1978-12-23 | 1979-06-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-06-23 | 1982-12-23 | 1983-06-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-06-23 | 1986-12-23 | 1987-06-24 | $7700.00 | Window Closed / Lapsed |