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US3890325A
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Leurocolombine
Assignee: Eli Lilly and Co
•
Filing: 1974-05-15
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Granted: 1975-06-17
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Expires: 1994-05-15
Abstract
Abstract Leurocolombine, a novel indole-dihydroindole alkaloid obtained in small quantities from Catharanthus roseus active as antimitotic.
Inventors
- 👤 Susan L Smith
- 👤 Douglas E Dorman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 05:40
CPC Classifications
C; C07; C07D; C07D519/00; C07D519/04
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
5 words
LEUROCOLOMBINE, REPRESENTED BY THE FORMULA:
Claim 2
Dependent Claim
5 words
LEUROCOLOMBINE, REPRESENTED BY THE FORMULA:
Claim 3
Dependent Claim
109 words
Leurocolombine having the following characteristics: pKa''5 at 5.05, 6.3; Infra-red absorption maxima at 2.80, 2.88, 3.35, 5.74, 6.18, 6.65, 6.82, 6.95, 7.25, 7.50, 8.11, 9.60, 9.90 and 10.75 microns; Ultra-violet absorption maxima at 217 (am 51.091) and 265 (am 15,666) millimicrons; Molecular weight, 826; Empirical formula, C46H58N4O10; Ion fragments by mass spectroscopy, m/e 795, 767, 749, 667, 649, 282, 170, 156, 154, 152, 144, 143; proton nmr spectrum, chemical shifts in ppm at 7.51, 7.13, 0.90, 3.60, 3.75, 7.01, 3.84, 6.15, 5.29, 5.85, 5.48, 0.78, 2.68, 3.79, 2.70, 2.10 and 4.16; and forming a sulfate salt with the following X-ray powder diffraction pattern using filtered chromium radiation at 2.2896A
Claim 4
Dependent Claim
109 words
Leurocolombine having the following characteristics: pKa''5 at 5.05, 6.3; Infra-red absorption maxima at 2.80, 2.88, 3.35, 5.74, 6.18, 6.65, 6.82, 6.95, 7.25, 7.50, 8.11, 9.60, 9.90 and 10.75 microns; Ultra-violet absorption maxima at 217 (am 51.091) and 265 (am 15,666) millimicrons; Molecular weight, 826; Empirical formula, C46H58N4O10; Ion fragments by mass spectroscopy, m/e 795, 767, 749, 667, 649, 282, 170, 156, 154, 152, 144, 143; proton nmr spectrum, chemical shifts in ppm at 7.51, 7.13, 0.90, 3.60, 3.75, 7.01, 3.84, 6.15, 5.29, 5.85, 5.48, 0.78, 2.68, 3.79, 2.70, 2.10 and 4.16; and forming a sulfate salt with the following X-ray powder diffraction pattern using filtered chromium radiation at 2.2896A
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-06-16 | 1978-12-16 | 1979-06-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-06-16 | 1982-12-16 | 1983-06-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-06-16 | 1986-12-16 | 1987-06-17 | $7700.00 | Window Closed / Lapsed |