Patent US3887700A successfully refreshed from Google Patents.
US3887700A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Analgesic formulations
Assignee: Aspro Nicholas Ltd
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Filing: 1973-11-12
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Granted: 1975-06-03
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Expires: 1993-11-12
Abstract
Abstract Free-flowing readily wettable aspirin particles comprise a core of aspirin substantially encompassed by a layer comprising a water-soluble pharmaceutically acceptable coating material having a melting point of at least 105*C, said coating material including at least one coating agent selected from low molecular weight amino acids, sugars, sugar alcohols and mixtures thereof, and a process for preparation of such particles comprises the steps of preparing a suspension of aspirin in an aqueous solution containing the coating material, and spray-drying said suspension, the ingredients in the suspension being made present in such relative amounts that the spray-drying step results in the formation of the particles having the characteristics set forth.
Inventors
- 👤 Graham Arthur Boncey
- 👤 Maurice John Hedge
- 👤 James Rae Henderson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 17:49
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/60; A61K9/00; A61K9/0002; A61K9/0007; A61K9/48; A61K9/50
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
159 words
An effervescent composition comprising one part of free flowing readily wetable coated aspirin particles, of which at least 95 percent by weight are not more than 150 microns, comprising: one part of aspirin to one to one ninth part of a coating agent comprising at least one ingredient selected from glycine, methionine, sucrose, lactose, arabino galactan sugar products, manitol, inositol, and sorbitol; said coating agent also comprising up to 5 percent by weight of a wetting agent; and up to 10 percent by weight of a film forming agent selected from hydroxyethyl cellulose, hydroxy propyl methyl cellulose, sodium carboxymethyl cellulose, starches, dextrin, dextran, gun acacia, gum tragicanth and polyvinyl pyrrolidone: and three to six parts of an effervescent couple constituted by a mixture of a pharmaceutically acceptable acid and alkalai which in contact with water will react to liberate carbon dioxide, the ratio be weight of the aspirin to the total weight of the composition being greater than 1:8.
Claim 2
Dependent Claim
159 words
An effervescent composition comprising one part of free flowing readily wetable coated aspirin particles, of which at least 95 percent by weight are not more than 150 microns, comprising: one part of aspirin to one to one ninth part of a coating agent comprising at least one ingredient selected from glycine, methionine, sucrose, lactose, arabino galactan sugar products, manitol, inositol, and sorbitol; said coating agent also comprising up to 5 percent by weight of a wetting agent; and up to 10 percent by weight of a film forming agent selected from hydroxyethyl cellulose, hydroxy propyl methyl cellulose, sodium carboxymethyl cellulose, starches, dextrin, dextran, gun acacia, gum tragicanth and polyvinyl pyrrolidone: and three to six parts of an effervescent couple constituted by a mixture of a pharmaceutically acceptable acid and alkalai which in contact with water will react to liberate carbon dioxide, the ratio be weight of the aspirin to the total weight of the composition being greater than 1:8.
Claim 3
Dependent Claim
158 words
AN EFFERVESCENT COMPOSITION COMPRISING ONE PART OF FREE FLOWING READILY WETABLE COATED ASPIRIN PARTICLES, OF WHICH AT LEAST 95 PERCENT BY WEIGHT ARE NOT MORE THAN 150 MICRONS, COMPRISING: ONE PART OF ASPIRIN TO ONE TO ONE NINTH PART OF A COATING AGENT COMPRISING AT LEAST INGREDIENT SELECTED FROM GLYCINE, METHIONINE, SUCROSE, LACTOSE, ARABINO GALACTAN SUGAR PRODUCTS, MANITOL, INOSITOL, AND SORBITOL; SAID COATING AGENT ALSO COMPRISING UP TO 5 PERCENT BY WEIGHT OF A WETTING AGENT; AND UP TO 10 PERCENT BY WEIGHT OF A FILM FORMING AGENT SELECTED FROM HYDROXYETHYL CELLULOSE, HYDROXY PROPYL METHYL CELLULOSE, SODIUM CARBOXYMETHYL CELLULOSE, STARCHES, DEXTRIN, IDEXTRAN, GUN ACACIA, GUM TRAGICANTH AND POLYVINYL PYRRILIDONE: AND THREE TO SIX PARTS OF AN EFFERVESCENT COUPLE CONSTITUTED BY A MIXTURE OF A PHARMACEUTICALLY ACCEPTABLE ACID AND ALKALAI WHICH IN CONTACT WITH WATER WILL REACTO TO LIBERATE CARBON DIOXIDE, THE RATIO BE WEIGHT OF THE ASPIRIN TO THE TOTAL WEIGHT OF THE COMPOSITION BEING GREATER THAN 1:8.
Claim 4
Dependent Claim
158 words
AN EFFERVESCENT COMPOSITION COMPRISING ONE PART OF FREE FLOWING READILY WETABLE COATED ASPIRIN PARTICLES, OF WHICH AT LEAST 95 PERCENT BY WEIGHT ARE NOT MORE THAN 150 MICRONS, COMPRISING: ONE PART OF ASPIRIN TO ONE TO ONE NINTH PART OF A COATING AGENT COMPRISING AT LEAST INGREDIENT SELECTED FROM GLYCINE, METHIONINE, SUCROSE, LACTOSE, ARABINO GALACTAN SUGAR PRODUCTS, MANITOL, INOSITOL, AND SORBITOL; SAID COATING AGENT ALSO COMPRISING UP TO 5 PERCENT BY WEIGHT OF A WETTING AGENT; AND UP TO 10 PERCENT BY WEIGHT OF A FILM FORMING AGENT SELECTED FROM HYDROXYETHYL CELLULOSE, HYDROXY PROPYL METHYL CELLULOSE, SODIUM CARBOXYMETHYL CELLULOSE, STARCHES, DEXTRIN, IDEXTRAN, GUN ACACIA, GUM TRAGICANTH AND POLYVINYL PYRRILIDONE: AND THREE TO SIX PARTS OF AN EFFERVESCENT COUPLE CONSTITUTED BY A MIXTURE OF A PHARMACEUTICALLY ACCEPTABLE ACID AND ALKALAI WHICH IN CONTACT WITH WATER WILL REACTO TO LIBERATE CARBON DIOXIDE, THE RATIO BE WEIGHT OF THE ASPIRIN TO THE TOTAL WEIGHT OF THE COMPOSITION BEING GREATER THAN 1:8.
Claim 5
Dependent Claim
13 words
A composition according to claim 1 in which the coating material includes mannitol.
Claim 6
Dependent Claim
13 words
A composition according to claim 1 in which the coating material includes glycine.
Claim 7
Dependent Claim
60 words
A composition according to claim 1 in which the aspirin particles have the following properties: i. the melting point of the coating material being above 150*C ii. the ratio by weight of aspirin to coating material being from about 7:1 to about 1:1 iii. at least 95% by weight of the particlEs being not greater in size than 105 microns.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-06-02 | 1978-12-02 | 1979-06-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-06-02 | 1982-12-02 | 1983-06-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-06-02 | 1986-12-02 | 1987-06-03 | $7700.00 | Window Closed / Lapsed |