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1-Amino substituted 1-cycloalkane derivatives of 7-aminocephalosporanic acid and 7-aminodesacetoxy cephalosporanic acid

Assignee: ER Squibb and Sons LLC
•
Filing: 1972-08-21
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Granted: 1975-06-03
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Expires: 1992-08-21
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Abstract

Abstract Disclosed herein are novel compounds of the formula WHEREIN W is -CH3 or -CH2OCOCH3, m is 0, 1 or 2; R is alkyl of from 1 to 7 carbon atoms, hydroxy or halogen; n is 0, 1, 2 or 3; R1 is phenyl, naphthyl, substituted phenyl or naphthyl wherein the substituent is halogen, hydroxy, or alkyl, alkoxy or acyl, each of from 1 to 4 carbon atoms, or amido; and Z is hydrogen, alkyl of from 1 to 7 carbon atoms or a salt forming ion. These compounds, prepared by condensing a Schiff''s base of a 1-amino-1cycloalkane carboxylic acid with 7-ACA or 7-ADCA, are useful as antibacterial agents.

Inventors

  • 👤 Bong Kuk Lee
  • 👤 Saul Lewis Neidleman
  • 👤 Dewey D Y Ryu

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-02 19:51
CPC Classifications
C; C07; C07D; C07D501/00; C07D501/14; C07D501/16; C07D501/20

Claims Analysis

Total Claims: 10
Claim 1
Independent Claim 5 words
A compound of the formula
Claim 2
Dependent Claim 5 words
A compound of the formula
Claim 3
Dependent Claim 5 words
A COMPOUND OF THE FORMULA
Claim 4
Dependent Claim 5 words
A COMPOUND OF THE FORMULA
Claim 5
Dependent Claim 14 words
A compound of claim 1 wherein Q is -N CHR1 and W is -CH3.
Claim 6
Dependent Claim 13 words
A compound of claim 1 wherein Q is -NHCH2R1 and W is -CH3.
Claim 7
Dependent Claim 14 words
A compound of claim 1 wherein Q is -N CHR1 and W is -CH2OCOCH3.
Claim 8
Dependent Claim 13 words
A compound of claim 1 wherein Q is -NHCH2R1 and W is -CH2OCOCH3.
Claim 9
Dependent Claim 12 words
A compound according to claim 5 having the name 7-((1-(((2-hydroxy-1-naphthyl)methyl)amino)cyclopent-1-yl) -carboxamido)cephalosporanic acid.
Claim 10
Dependent Claim 12 words
A compound according to claim 4 having the name 7-((1-(((2-hydroxy-1-naphthyl)methylene)amino)cyclopent-1-yl) -carboxamido)cephalosporanic acid.

References Cited (Backward Citations)

US3634417A Cited
US3592812A Cited
US3647781A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1978-06-02 1978-12-02 1979-06-03 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1982-06-02 1982-12-02 1983-06-03 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1986-06-02 1986-12-02 1987-06-03 $7700.00 Window Closed / Lapsed

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