Patent US3886272A successfully refreshed from Google Patents.
US3886272A
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Saponin-containing spermatocidal compositions
Assignee: SRI International Inc
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Filing: 1974-04-05
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Granted: 1975-05-27
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Expires: 1994-04-05
Abstract
Abstract Saponins of the type found in Phytolacca dodecandra and Calendula officinalis are found to have utility as spermatocides and as antiblastocyst and abortion agents, they manifesting such activity either when employed in extract form or in the form of compounds having the structure of those found in said extracts. They are of low mammalian toxicity and have evidenced no significant topical irritation on being introduced into the vaginal cavity of the test animals or when applied to abraded or unabraded rabbit skin. These saponins are totally efffective even at low concentration in inducing substantially instantaneous inactivation of both human and animal sperm, and upon interuterine administration they are also capable of destroying blastocysts both before as well as after implantation.
Inventors
- 👤 Robert M Parkhurst
- 👤 Sidney J Stolzenberg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 23:26
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/24; C07H15/256
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
33 words
AS A SPERMATOCIDE ADAPTED TO BE INTRODUCED INTO THE VAGINA PRIOR TO INTERCOURSE AND THUS PREVENT THE OCCURRENCE OF PREGNANCY, A COMPOSITION COMPRISING AT LEAST ONE SPERMATOCIDALLY ACTIVE SAPONIN MATERIAL HAVING TH STRUCTURE
Claim 2
Dependent Claim
33 words
AS A SPERMATOCIDE ADAPTED TO BE INTRODUCED INTO THE VAGINA PRIOR TO INTERCOURSE AND THUS PREVENT THE OCCURRENCE OF PREGNANCY, A COMPOSITION COMPRISING AT LEAST ONE SPERMATOCIDALLY ACTIVE SAPONIN MATERIAL HAVING TH STRUCTURE
Claim 3
Dependent Claim
16 words
The composition of claim 1 wherein the saponin material represents an extract obtained from endod berries.
Claim 4
Dependent Claim
16 words
The composition of claim 1 wherein the saponin material represents an extract obtained from marigold plants.
Claim 5
Dependent Claim
11 words
The composition of claim 1 wherein the saponin material represents oleanoglycotoxin-A.
Claim 6
Dependent Claim
18 words
The composition of claim 1 wherein the saponin material represents 3-0-(4''-0-( Beta -D-glucopyranosyl)-3''-0-( Beta -D-galactopyranosyl)- Beta -D-glucopyranosyl)-olean-12-ene-28-oic acid.
Claim 7
Dependent Claim
19 words
The composition of claim 1 wherein the saponin material represents 3-0-(2''-0-(2''''-0-( Alpha -L-rhamnopyranosyl)- Beta -D-glucopyranosyl)- Beta -D-glucopyranosyl) olean-12-ene-28-oic acid.
Claim 8
Dependent Claim
19 words
The composition of claim 1 wherein the saponin material represents 3-0-(2''-0-(2''''-0-( Alpha -L-rhamnopyranosyl)- Beta -D-galactopyranosyl)- Beta -D-glucopyranosyl) olean-12-ene-28-oic acid.
Claim 9
Independent Claim
38 words
The method of preventing the occurrence of pregnancy in a mammal which comprises introducing into the vagina, prior to intercourse, a spermatocidally effective dosage of a composition comprising at least one spermatocidally active saponin material having the structure
Claim 10
Independent Claim
38 words
The method of preventing the occurrence of pregnancy in a mammal which comprises introducing into the vagina, prior to intercourse, a spermatocidally effective dosage of a composition comprising at least one spermatocidally active saponin material having the structure
Claim 11
Dependent Claim
18 words
The method of claim 8 wherein the saponin material has the structure of that extractable from endod berries.
Claim 12
Dependent Claim
18 words
The method of claim 8 wherein the saponin material has the structure of that extractable from marigold plants.
Claim 13
Dependent Claim
11 words
The method of claim 8 wherein the saponin material is oleanoglycotoxin-A.
Claim 14
Dependent Claim
17 words
The method of claim 8 wherein the saponin material is 3-0-(4''-0-( Beta -D-glucopyranosyl)-3''-0-( Beta -D-galactopyranosyl)-Beta -D-glucopyranosyl)-olean-12-ene-28-oic acid.
Claim 15
Dependent Claim
19 words
The method of claim 8 wherein the saponin material is 3-0-(2''-0-(2''''-0-( Alpha -L-rhamnopyranosyl)- Beta -D-glucopyranosyl)- Beta -D-glucopyranosyl) olean-12-ene-28-oic acid.
Claim 16
Dependent Claim
19 words
The method of claim 8 wherein the saponin material is 3-0-(2''-0-(2''''0-0-( Alpha -L-rhamnopyranosyl)- Beta -D-galactopyranosyl)- Beta -D-glucopyranosyl) olean-12-ene-28-oic acid.
Claim 17
Independent Claim
43 words
The method of terminating pregnancy in a mammal following conception either before or after blastocyst implantation, which comprises introducing into the uterus of said mammal an amount effective to terminate pregnancy of a composition comprising at least one saponin material having the structure
Claim 18
Independent Claim
43 words
The method of terminating pregnancy in a mammal following conception either before or after blastocyst implantation, which comprises introducing into the uterus of said mammal an amount effective to terminate pregnancy of a composition comprising at least one saponin material having the structure
References Cited (Backward Citations)
US3442911A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-05-26 | 1978-11-25 | 1979-05-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-05-26 | 1982-11-25 | 1983-05-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-05-26 | 1986-11-25 | 1987-05-27 | $7700.00 | Window Closed / Lapsed |