Iodophor-steroid compound pharmaceutical compositions

Claim 2

A GERMICIDAL ANTI-INFLAMMATORY PHARMACEUTICAL COMPOUND SELECTED FROM THE GROUP CONSISTING OF POLYVINYLPYRROLICDONE-IODINE-CORTISONE, POLYVINYL-PYRROLIDONE-IODINE-CORTISONE ACETATE, POLYVINYLPYRROLIDONE-HYDROCORTISONE, POLYVINYLPYRROLIDONE-HYDROCORTISONE ACETATE, POLYVINYLPYRROLIDONE-IODINE-PREDNIOSONE, POLYVINYLPYRROLIDONE-IODINEPREDNISONE ACETATE, POLYVINYL-PYRROLIDONE-IODINEPREDNISOLONE, POLYVINYLPYRROLIDONE-IODINE-PREDNISOLONE ACETATE.

Claim 3

The compound of claim 1, said compound being polyvinylpyrrolidone-iodine cortisone.

Claim 4

The compound of claim 1, said compound being polyvinylpyrrolidone-iodine cortisone acetate.

Claim 5

The compound of claim 1, said compound being polyvinylpyrrolidone-iodine hydrocortisone.

Claim 6

The compound of claim 1, said compound being polyvinylpyrrolidone-iodine hydrocortisone acetate.

Claim 7

The compound of claim 1, said compound being polyvinylpyrrolidone-iodine prednisone.

Claim 8

The compound of claim 1, said compound being polyvinylpyrrolidone-iodine prednisone acetate.

Claim 9

The compound of claim 1, said compound being polyvinylpyrrolidone-iodine prednisolone.

Claim 10

The compound of claim 1, said compound being polyvinylpyrrolidone-iodine prednisolone acetate.

Claim 11

A pharmaceutical germicidal composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier therefrom.

Claim 12

The pharmaceutical composition of claim 10, said compound being polyvinylpyrrolidone-iodine-hydrocortisone acetate.

Claim 13

The pharmaceutical composition of claim 10, said compound being polyvinylpyrrolidone-iodine cortisone.

Claim 14

The pharmaceutical composition of claim 10, said compound being polyvinylpyrrolidone-iodine cortisone acetate.

Claim 15

The pharmaceutical composition of claim 10, said compound being polyvinylpyrrolidone-iodine hydrocortisone.

Claim 16

The pharmaceutical composition of claim 10, said compound being polyvinylpyrrolidone-iodine prednisone.

Claim 17

The pharmaceutical composition of claim 10, said compound being polyvinylpyrrolidone-iodine prednisone acetate.

Claim 18

The pharmaceutical composition of claim 10, said compound being polyvinylpyrrolidone-iodine prednisolone.

Claim 19

The pharmaceutical composition of claim 10, said compound being polyvinylpyrrolidone-iodine prednisolone acetate.

Claim 20

A pharmaceutical germicidal anti-inflammatory composition comprising from one to ten parts by weight of polyvinylpyrrolidone-iodine and from one-tenth part to five parts by weight of a steroid compound selected from the group consisting of cortisone, cortisone acetate, hydrocortisone, hydrocortisone acetate, prednisone, prednisone acetate, prednisolone, prednisolone acetate and a pharmaceutically acceptable carrier therefor.

Claim 21

A pharmaceutical germicidal anti-inflammatory composition comprising from one to ten parts by weight of polyvinylpyrrolidone-iodine and from one-tenth part to five parts by weight of a steroid compound selected from the group consisting of cortisone, cortisone acetate, hydrocortisone, hydrocortisone acetate, prednisone, prednisone acetate, prednisolone, prednisolone acetate and a pharmaceutically acceptable carrier therefor.

Claim 22

The pharmaceutical composition of claim 19, said pharmaceutically acceptable vehicle being selected from the group consisting of polyethylene glycols having a molecular weight of from 200 to 6000, glycerin and propylene glycol.

Claim 23

The method for preparing a compound of claim 1, comprising the steps of: a. dissolving 12 parts of polyvinylpyrrolidone-iodine in 50 parts of ethanol, b. warming and stirring to achieve complete solution, c. adding one part of a steroid compound selected from the group consisting of cortisone, corTisone acetate, hydrocortisone, hydrocortisone acetate, prednisone, prednisone acetate, prednisolone, prednisolone acetate, d. adjusting the pH of the mixture to be not less than pH 4 and not greater than pH 6, e. stirring, while warming, for a period of at least one hour, f. concentrating the solvent and isolating the formed polyvinylpyrrolidone-iodine-steroid molecular complex compound.

Claim 24

The method of claim 21, said steroid being cortisone and said polyvinylpyrrolidone-iodine steroid molecular complex compound isolated, being polyvinylpyrrolidone-iodine cortisone.

Claim 25

The method of claim 21, said steroid being cortisone acetate and said polyvinylpyrrolidone-iodine steroid molecular complex compound isolated, being polyvinylpyrrolidone-iodine cortisone acetate.

Claim 26

The method of claim 21, said steroid being hydrocortisone and said polyvinylpyrrolidone-iodine steroid molecular complex compound isolated, being polyvinylpyrrolidone-iodine hydrocortisone.

Claim 27

The method of claim 21, said steroid being prednisone and said polyvinylpyrrolidone-iodine steroid molecular complex compound isolated, being polyvinylpyrrolidone-iodine prednisone.

Claim 28

The method of claim 21, said steroid being prednisone acetate and said polyvinylpyrrolidone-iodine steroid molecular complex compound isolated, being polyvinylpyrrolidone-iodine prednisone acetate.

Claim 29

The method of claim 21, said steroid being prednisolone and said polyvinylpyrrolidone-iodine steroid molecular complex compound isolated, being polyvinylpyrrolidone-iodine prednisolone.

Claim 30

The method of claim 21, said steroid being prednisolone acetate and said polyvinylpyrrolidone-iodine steroid molecular complex compound isolated, being polyvinylpyrrolidone-iodine prednisolone acetate.

Claim 33

A method for treating inflammatory skin disease on the skin of a human or animal comprising applying from one to six times daily, a therapeutically sufficient quantity of a compound of claim 1 to said inflamed skin of said human or animal.

Claim 34

A method for treating inflammatory skin disease on the skin of a human or animal having said inflammatory skin disease complicated by infection comprising applying from one to six times daily, a therapeutically sufficient quantity of a composition of claim 19 to said inflamed skin of a human or animal.