US3886167A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2-Aryl-6-trifluoromethyl-4-pyridylcarbinolamine antimalarials
Assignee: United States Department of the Army
•
Filing: 1974-03-06
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Granted: 1975-05-27
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Expires: 1994-03-06
Abstract
Abstract A series of 2-aryl-6-trifluoromethyl-4-pyridylcarbinolamines is herein disclosed which has value in treatment of plasmodial infections. The compounds have substituted phenyl groups at position 2- on the pyridine moiety, with the electronegative substituents present on the phenyl nuclei. The syntheses of such series is described, together with a method for separation of racemates of a representative 4-pyridylcarbinolamine type.
Inventors
- 👤 Arthur B Ash
- 👤 Maurice P Lamontagne
- 👤 Anica Markovac
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 23:16
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/06; C07D213/16; C07D213/20; C07C; C07C59/00; C07C59/40; C07C59/76; C07C59/88; C07D213/24; C07D213/28; C07D213/30; C07D213/36; C07D213/38; C07D213/44; C07D213/46; C07D213/50; C07D213/60; C07D213/78; C07D213/79
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
4 words
COMPOUND OF THE FORMULA
Claim 2
Dependent Claim
4 words
COMPOUND OF THE FORMULA
Claim 3
Dependent Claim
14 words
A compound according to claim 1 wherein (Ar)2 is a trifluoromethyl substituted phenyl group.
Claim 4
Dependent Claim
10 words
The compound of claim 1, 2-(4-trifluoromethylphenyl)-6-trifluoromethyl-4-alpha-(2-piperidyl)pyridine carbinol or its salt.
Claim 5
Dependent Claim
14 words
The process for the preparation of a racemate of the compound of the formula
Claim 6
Dependent Claim
14 words
The process for the preparation of a racemate of the compound of the formula
Claim 7
Dependent Claim
9 words
The process of claim 4 wherein (Ar)2 is trifluoromethylphenyl.
Claim 8
Dependent Claim
34 words
The compound of claim 3 wherein the compound is a racemate having a melting point between about 172* to 174*C as the hydrochloride salt and between about 140* to 142*C as the free base.
Claim 9
Dependent Claim
24 words
The compound of claim 3 wherein the compound is a racemate having a melting point between about 232* to 234*C as the hydrochloride salt.
References Cited (Backward Citations)
US3764604A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-05-26 | 1978-11-25 | 1979-05-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-05-26 | 1982-11-25 | 1983-05-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-05-26 | 1986-11-25 | 1987-05-27 | $7700.00 | Window Closed / Lapsed |