New substrates for diagnostic use, with high susceptibility to trypsin and other proteolytic enzymes of the type peptide peptidohydrolases
Abstract
Abstract Substrate with high susceptibility to peptide peptidohydrolases represented by the formula: OR ITS SALTS, WHERE R1 is hydrogen, an alkyl-carbonyl having 112 carbon atoms, a omega -aminoalkyl-carbonyl having 1-12 carbon atoms in a straight chain, cyclohexyl-carbonyl, a omega cyclohexylalkyl-carbonyl having 1-6 carbon atoms in a straight chain, 4-aminomethyl-cyclohexyl-carbonyl, benzoyl, a omega phenylalkylcarbonyl having 1-6 carbon atoms in a straight chain, benzene-sulphonyl or 4-toluene-sulphonyl; R2 is hydrogen, phenyl, cyclohexyl, or an alkyl having 1-6 carbon atoms; X is methylene or a single bond; R3 is a straight, branched or cyclic alkyl group having 3-8 carbon atoms; R4 is a straight, branched or cyclic alkyl group having 3-8 carbon atoms, phenyl or benzyl; n is 3 or 4; R5 is hydrogen or guanyl; and R6 is phenyl, nitrophenyl, methylnitrophenyl, dinitrophenyl, naphthyl, nitronaphthyl, quinolyl, or nitroquinolyl.
Inventors
- 👤 Karl Goran Claeson
- 👤 Birgitta Gunilla Karlsson
- 👤 Lars-Gundro Svendsen
Bibliographic Details
Claims Analysis
Total Claims: 20References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-05-26 | 1978-11-25 | 1979-05-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-05-26 | 1982-11-25 | 1983-05-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-05-26 | 1986-11-25 | 1987-05-27 | $7700.00 | Window Closed / Lapsed |