US3886044A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process of making cephamycin C by fermentation
Assignee: Merck and Co Inc
•
Filing: 1974-04-25
•
Granted: 1975-05-27
•
Expires: 1994-04-25
Abstract
Abstract Increased yields of the known and useful antibiotic cephamycin C (7-(D-5-amino-5-carboxyvaleramido)-3-(carbamoyloxymethyl)-7methoxy-3-cephem -4-carboxylic acid) are obtained by the addition of D-lysine or DL-lysine to fermentation media composed of complex organic or chemically defined nutrients.
Inventors
- 👤 Edward Inamine
- 👤 Jerome Birnbaum
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 20:49
CPC Classifications
C; C12; C12P; C12P35/00; C12P35/08; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/886
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
34 words
IN THE PROCESS FOR PREPARING CEPHAMYCIN C BY GROWING A CEPHAMYCIN C PRODUCING SPECIE OF STREPTOMYCES IN A NUTRIENT MEDIUM, THE IMPROVEMENT WHICH COMPRISES THE ADDITION OF D-LYSINE OR DL-LYSINE TO THE NUTRIENT MEDIUM.
Claim 2
Dependent Claim
34 words
IN THE PROCESS FOR PREPARING CEPHAMYCIN C BY GROWING A CEPHAMYCIN C PRODUCING SPECIE OF STREPTOMYCES IN A NUTRIENT MEDIUM, THE IMPROVEMENT WHICH COMPRISES THE ADDITION OF D-LYSINE OR DL-LYSINE TO THE NUTRIENT MEDIUM.
Claim 3
Dependent Claim
21 words
The process of claim 1 wherein the Streptomyces specie is selected from the group consisting of Streptomyces lactamdurans or Streptomyces clavuligerus.
Claim 4
Dependent Claim
15 words
The process of claim 2 wherein the nutrient medium is a complex organic nutrient medium.
Claim 5
Dependent Claim
33 words
The process of claim 3 wherein the D-lysine or DL-lysine is added in the amount of from about 0.05 to 0.20 percent (weight/volume) of the complex organic nutrient media, calculated as the hydrochloride.
Claim 6
Dependent Claim
11 words
The process of claim 4 wherein the organism is Streptomyces lactamdurans.
Claim 7
Dependent Claim
11 words
The process of claim 4 wherein the organism is Streptomyces clavuligerus.
Claim 8
Dependent Claim
10 words
The process of claim 4 wherein the additive is D-lysine.
Claim 9
Dependent Claim
10 words
The process of claim 4 wherein the additive is DL-lysine.
Claim 10
Dependent Claim
11 words
The process of claim 2 wherein the nutrient medium is synthetic.
Claim 11
Dependent Claim
31 words
The process of claim 9 wherein the D-lysine or DL-lysine is added in the amount of from about 0.01 to 0.80 percent (weight/volume) of the synthetic media, calculated as the hydrochloride.
Claim 12
Dependent Claim
11 words
The process of claim 10 wherein the organism is Streptomyces lactamdurans.
Claim 13
Dependent Claim
11 words
The process of claim 10 wherein the organism is Streptomyces clavuligerus.
Claim 14
Dependent Claim
10 words
The process of claim 10 wherein the additive is D-lysine.
Claim 15
Dependent Claim
10 words
The process of claim 10 wherein the additive is DL-lysine.
References Cited (Backward Citations)
US3769169A
Cited
US3770590A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-05-26 | 1978-11-25 | 1979-05-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-05-26 | 1982-11-25 | 1983-05-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-05-26 | 1986-11-25 | 1987-05-27 | $7700.00 | Window Closed / Lapsed |