US3884761A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bonding of enzymes, enzyme derivatives and other compounds to polymeric materials
Assignee: KOCH-LIGHT Ltd ROOKWOOD WAY HAVERHILL SUFFOLK ENGLAND CB9 8PB
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Filing: 1972-12-04
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Granted: 1975-05-20
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Expires: 1992-12-04
Abstract
Abstract This invention discloses a new method of preparing a hydrophilic water-insoluble polymer with molecular chains having repeating thiol or thiolacetone side groupings to which biologically active molecules can be attached.
Inventors
- 👤 David Thomas Cowling
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 18:11
CPC Classifications
C; C08; C08F; C08F8/00; C08F8/12; C08F220/00; C08F220/02; C08F220/52; C08F220/54; C08F220/56; C12; C12N; C12N11/00; C12N11/02; C12N11/08; C12N11/082; C12N11/087; C08F2800/00; C08F2800/20
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
82 words
A METHOD OF MAKING A HYDROPHILIC WATER-INSOLUBLE POLYMER WITH MOLECULAR CHAINS HAVING REPEATIG THIOL SIDE GROUPINGS TO WHICH BIOLOGICALLY ACTIVE MOLECULES ARE ATTACHES TO GIVE A COMBINED WATER-INSOLUBLE POLYMER AND BIOLOGICALLYACTIVE MOLECULE COMPRISING, A. POLYMERIZING AN N-SUBSTITUTED THIAZOLIDINE IN THE PRESENCE OF AN INERT GAS TO GIVE POLYMER HAVING THIAZOLIDINE SIDE GROUPS, B. HYDROLYZING SAID THIOAZOLIDINE SIDE GROUPINGS TO GIVE A POLYMER HAVING THIOL SIDE GROUPINGS, AND C. BONDING BIOLOGICALLY ACTIVE MOLECULES THROUGH THE THIOL SIDE GROUPS TO THE HYDROPHILIC WATER-INSOLUBLE POLYMER.
Claim 2
Independent Claim
82 words
A METHOD OF MAKING A HYDROPHILIC WATER-INSOLUBLE POLYMER WITH MOLECULAR CHAINS HAVING REPEATIG THIOL SIDE GROUPINGS TO WHICH BIOLOGICALLY ACTIVE MOLECULES ARE ATTACHES TO GIVE A COMBINED WATER-INSOLUBLE POLYMER AND BIOLOGICALLYACTIVE MOLECULE COMPRISING, A. POLYMERIZING AN N-SUBSTITUTED THIAZOLIDINE IN THE PRESENCE OF AN INERT GAS TO GIVE POLYMER HAVING THIAZOLIDINE SIDE GROUPS, B. HYDROLYZING SAID THIOAZOLIDINE SIDE GROUPINGS TO GIVE A POLYMER HAVING THIOL SIDE GROUPINGS, AND C. BONDING BIOLOGICALLY ACTIVE MOLECULES THROUGH THE THIOL SIDE GROUPS TO THE HYDROPHILIC WATER-INSOLUBLE POLYMER.
Claim 3
Dependent Claim
14 words
The method according to claim 1 wherein said N-substituted thiazolidine is N-acryloyl-4-carbomethoxy-2,2 dimethyl thiazolidine.
Claim 4
Dependent Claim
18 words
The method according to claim 2 wherein said N-acryloyl-4-carbomethyoxy-2,2 dimethyl thiazolidine is additionally polymerized with acrylamide and methylene-bis-acrylamide.
Claim 5
Dependent Claim
21 words
The method according to claim 3 wherein said polymerization is performed in an ethanolic solution and said inert gas is nitrogen.
Claim 6
Dependent Claim
14 words
The method according to claim 1 wherein said hydrolyzing is performed with hydrochloric acid.
Claim 7
Dependent Claim
16 words
The method according to claim 1 wherein said thiazolidine is additionally polymerized with acrylamide and methylene-bis-acrylamide.
References Cited (Backward Citations)
US3674767A
Cited
US3761357A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-05-19 | 1978-11-18 | 1979-05-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-05-19 | 1982-11-18 | 1983-05-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-05-19 | 1986-11-18 | 1987-05-20 | $7700.00 | Window Closed / Lapsed |