Patent US2449489A successfully refreshed from Google Patents.
Patent US3882858A successfully refreshed from Google Patents.
US3882858A
Expired / Lapsed
US
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Surgical synthetic-resin material and method of treating osteomyelitis
Assignee: Merck Patent GmbH
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Filing: 1974-04-17
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Granted: 1975-05-13
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Expires: 1994-04-17
Abstract
Abstract Osteomyelitis is treated by filling an osteomyelitic cavity with particles of 1-20 mm diameter of a polymethacrylate, polyacrylate or copolymer thereof which is impregnated with gentamycin or other antibiotic. Particles of such antibiotic impregnated polymer joined together by a thread or wire are particularly useful for this purpose.
Inventors
- 👤 Klaus Klemm
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 20:34
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1635; A61L; A61L27/00; A61L27/50; A61L27/54; C; C08; C08K; C08K5/00; C08K5/0008; C08K5/0058; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/406
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
37 words
A METHOD OF TREATING OSTEROMYELITIS WHICH COMPRISES IMPLANTING IN AN OSTEROMYELITIC ACITY STERILE PARTICLES HAVING A DIAMETER OF 1 - 20 MM. OF A SOLID PHYSIOLOGICALLY ACCEPTABLE BONE CEMENT IMPREGNATED WITH AT LEAST ONE TOPICAL EFFECTIVE ANTIBIOTIC.
Claim 2
Independent Claim
37 words
A METHOD OF TREATING OSTEROMYELITIS WHICH COMPRISES IMPLANTING IN AN OSTEROMYELITIC ACITY STERILE PARTICLES HAVING A DIAMETER OF 1 - 20 MM. OF A SOLID PHYSIOLOGICALLY ACCEPTABLE BONE CEMENT IMPREGNATED WITH AT LEAST ONE TOPICAL EFFECTIVE ANTIBIOTIC.
Claim 3
Dependent Claim
15 words
A method according to claim 1 wherein the particles have a diameter of 5-15 mm.
Claim 4
Dependent Claim
20 words
A method according to claim 1 wherein the bone cement is consisting essentially of polymethacrylate, a polyacrylate or copolymer thereof.
Claim 5
Dependent Claim
18 words
A method according to claim 3 wherein the particles are a copolymer of methyl methacrylate and methyl acrylate.
Claim 6
Dependent Claim
11 words
A method according to claim 1 wherein the antibiotic is gentamycin.
Claim 7
Dependent Claim
21 words
A method according to claim 1 wherein the particles are impregnated with about 0.2 - 15 percent by weight of antibiotic.
Claim 8
Dependent Claim
23 words
A method according to claim 1 wherein the particles are impregnated with about 1-4 percent by weight of gentamycin, calculated as gentamycin base.
Claim 9
Dependent Claim
21 words
A method according to claim 1 wherein individual particles of the polymer are connected by a surgically acceptable thread or wire.
Claim 10
Dependent Claim
26 words
A method according to claim 8 wherein the particleS have a diameter of 5-15 mm. and are joined together by a surgically acceptable thread or wire.
Claim 11
Dependent Claim
31 words
A surgical device adapted for implantation into a wound comprising particles of a solid physiologically acceptable bone cement impregnated with an antibiotic joined together by a physiologically acceptable thread or wire.
Claim 12
Dependent Claim
31 words
A surgical device adapted for implantation into a wound comprising particles of a solid physiologically acceptable bone cement impregnated with an antibiotic joined together by a physiologically acceptable thread or wire.
Claim 13
Dependent Claim
16 words
A surgical device according to claim 10 wherein the particles have a diameter of 5-15 mm.
Claim 14
Dependent Claim
20 words
A surgical device according to claim 10 wherein the bone cement is consisting essentially of polymethacrylate, polyacrylate or copolymer thereof.
Claim 15
Dependent Claim
12 words
A surgical device according to claim 10 wherein the antibiotic is gentamycin.
Claim 16
Dependent Claim
22 words
A surgical device according to claim 10 wherein the particles are impregnated with about 0.2 - 15 percent by weight of antibiotic.
Claim 17
Dependent Claim
24 words
A surgical device according to claim 10 wherein the particles are impregnated with about 1-4 percent by weight of gentamycin, calculated as gentamycin base.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-05-12 | 1978-11-11 | 1979-05-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-05-12 | 1982-11-11 | 1983-05-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-05-12 | 1986-11-11 | 1987-05-13 | $7700.00 | Window Closed / Lapsed |