US3880588A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Diagnostic agent for detecting bilirubin
Assignee: Roche Diagnostics GmbH
•
Filing: 1973-07-24
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Granted: 1975-04-29
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Expires: 1993-07-24
Abstract
Abstract WHEREIN X is a stabilizing anion; R1 and R2, which may be the same or different, are halogen or lower alkyl or alkoxy and R3 and R4, which may be the same or different, are hydrogen, halogen, nitro, or lower alkyl or alkoxy; THE AROMATIC RING IN FORMULA (I) containing either (a) 1 to 3 halogen atoms or (b) one nitro group, but not both together; and an amount of an acid sufficient for a coupling reaction between bilirubin and said diazonium salt. Bilirubin, particularly as contained in body fluids, is determined with test strips comprising an absorbent
Inventors
- 👤 Walter Rittersdorf
- 👤 Werner Guthlein
- 👤 Dieter Berger
- 👤 Hans-Georg Rey
- 👤 Peter Rieckmann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 21:29
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/72; G01N33/728; Y; Y10; Y10S; Y10S436/00; Y10S436/903; Y10T; Y10T436/00; Y10T436/14; Y10T436/145555; Y10T436/146666
Claims Analysis
Total Claims: 32
Claim 1
Independent Claim
22 words
TEST STRIP FOR THE DETECTION OF BILIRUBIN IN BODY FLUIDS, WHICH COMPRISES AN ABSORBENT CARRIER CONTAINING A DIAZONIUM SALT OF THE FORMULA:
Claim 2
Dependent Claim
22 words
TEST STRIP FOR THE DETECTION OF BILIRUBIN IN BODY FLUIDS, WHICH COMPRISES AN ABSORBENT CARRIER CONTAINING A DIAZONIUM SALT OF THE FORMULA:
Claim 3
Dependent Claim
11 words
Test strip as claimed in claim 1, wherein R1 is halogen.
Claim 4
Dependent Claim
18 words
Test strip as claimed in claim 1, wherein R1 is alkyl of from 1 to 3 carbon atoms.
Claim 5
Dependent Claim
18 words
Test strip as claimed in claim 1, wherein R1 is alkoxy of from 1 to 3 carbon atoms.
Claim 6
Dependent Claim
11 words
Test strip as claimed in claim 1, wherein R2 is halogen.
Claim 7
Dependent Claim
18 words
Test strip as claimed in claim 1, wherein R2 is alkyl of from 1 to 3 carbon atoms.
Claim 8
Dependent Claim
18 words
Test strip as claimed in claim 1, wherein R2 is alkoxy of from 1 to 3 carbon atoms.
Claim 9
Dependent Claim
11 words
Test strip as claimed in claim 1, wherein R3 is hydrogen.
Claim 10
Dependent Claim
11 words
Test strip as claimed in claim 1, wherein R3 is halogen.
Claim 11
Dependent Claim
11 words
Test strip as claimed in claim 1, wherein R3 is nitro.
Claim 12
Dependent Claim
18 words
Test strip as claimed in claim 1, wherein R3 is alkyl of from 1 to 3 carbon atoms.
Claim 13
Dependent Claim
18 words
Test strip as claimed in claim 1, wherein R3 is alkoxy of from 1 to 3 carbon atoms.
Claim 14
Dependent Claim
23 words
Test strip as claimed in claim 1, wherein the aromatic ring of said diazonium salt contains a nitro group and no halogen atoms.
Claim 15
Dependent Claim
23 words
Test strip as claimed in claim 1, wherein the aromatic ring of said diazonium salt contains one halogen atom and no nitro group.
Claim 16
Dependent Claim
23 words
Test strip as claimed in claim 1, wherein the aromatic ring of said diazonium salt contains two halogen atoms and no nitro group.
Claim 17
Dependent Claim
23 words
Test strip as claimed in claim 1, wherein the aromatic ring of said diazonium salt contains three halogen atoms and no nitro group.
Claim 18
Dependent Claim
14 words
Test strip as claimed in claim 1, wherein said diazonium salt is 2,6-dichlorobenzene-diazonium fluoborate.
Claim 19
Dependent Claim
14 words
Test strip as claimed in claim 1, wherein said diazonium salt is 2-methoxy-4,6-dibromobenzene-diazonium fluoborate.
Claim 20
Dependent Claim
14 words
Test strip as claimed in claim 1, wherein said diazonium salt is 2,4,6-trichlorobenzene-diazonium toluenesulfonate.
Claim 21
Dependent Claim
11 words
Test strip as claimed in claim 1 also containing an activator.
Claim 22
Dependent Claim
19 words
Test strip as claimed in claim 20, wherein said activator is a phosphoric acid diester of the general formula:
Claim 23
Dependent Claim
18 words
Test strip as claimed in claim 1, wherein the stabilizing anion X is a fluoborate or aryl-sulfonate ion.
Claim 24
Dependent Claim
43 words
Test strip as claimed in claim 1, wherein the absorbent carrier is impregnated with a solution containing, per 100 ml., 0.01-2.0 g. of the diazonium salt, 3-20 g. of the phosphoric acid diester and 2-30 g. of a solid inorganic or organic acid.
Claim 25
Dependent Claim
26 words
Test strip as claimed in claim 1, wherein the absorbent carrier is impregnated with a solution containing 0.05-0.5 g. of the diazonium salt per 100 ml.
Claim 26
Dependent Claim
12 words
Test strip as claimed in claim 1, also containing a stabilizing agent.
Claim 27
Dependent Claim
21 words
Text strip as claimed in claim 25, wherein the stabilizing agent is sodium fluoborate, magnesium sulfate, sodium metaphosphate or an aryl-sulfonate.
Claim 28
Dependent Claim
28 words
Test strip as claimed in claim 1, wherein said absorbent carrier is a filter paper, glass fiber paper or a fabric or fleece made from acid-resistant synthetic fibers.
Claim 29
Dependent Claim
23 words
Test strip as claimed in claim 1, wherein said absorbent carrier is adhered to one end of a narrow strip of synthetic resin.
Claim 30
Dependent Claim
18 words
Test strip as claimed in claim 1, wherein said absorbent carrier is sealed between two synthetic resin films.
Claim 31
Dependent Claim
21 words
Test strip as claimed in claim 1, wherein said absorbent carrier is sealed between a synthetic resin film and a meshwork.
Claim 32
Dependent Claim
27 words
Method for detecting bilirubin in body fluids, which method comprises contacting a test sample suspected of containing bilirubin with a test strip as claimed in claim 1.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-04-28 | 1978-10-28 | 1979-04-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-04-28 | 1982-10-28 | 1983-04-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-04-28 | 1986-10-28 | 1987-04-29 | $7700.00 | Window Closed / Lapsed |