Organic amine-organic acid addition salts

Claim 2

A COSMETIC COMPOSITION FOR TOPICAL APPLICATION TO HUMAN SCALP AND SKIN CHARACTERIZED BY AN EXCESSIVE SECRETION OF SEBUM TO IMPROVE THE CONDITION THEREOF BY REDUCING SAID EXCESSIVE SECRETION OF SEBUM COMPRISING A SOLUTION IN A SOLVENT SELECTED FROM THE GROUP CONSISTING OF WATER, LOWER ALKANOL AND AN AQUEOUS SOLUTION OF LOWER ALKANOL OF 0.1 TO 5 PERCENT BY WEIGHT OF AN ACTIVE COMPOUND SELECTED FROM THE GROUP CONSISTING OF: 5-AMINO-3-THIA HEXANEDIOATE OF 2BENZYLTHIOETHYLAMMONIUM, 5-ACETAMIDO-3-THIA-HEXANEDIOTE OF DI(2-BENZYLTHIOETHYLAMMONIUM), 5-AMINO-3-THIA HEXANEDIOATE OF 2-(3-ALANYTHIO) ETHYLAMMONIUM, 5-AMINO-3-THIA HEXANEDIOATE OF 2METHYLTHIOETHYLAMMONIUM, 5-AMINO-3-THIA HEXANEDIOATE OF 3BENZYLTHIOPROPYLAMMONIUM, 2-AMINO-4-THIA HEPTANEDIOATE OF 2BENZYLTHIOETHYLAMMONIUM, 5-AMINO-3-THIA HEXANEDIOATE OF 2-(2,2,DIMETHOXYETHYLTHIO)-ETHYLAMMONIUM, 2-ACETAMIDO-3-BENZYLTHIO-PROPIONATE OF 2METHYLTHIOETHAMMONIUM), 5-BENZAMIDO-3-THIA-HEXANEDIOATE OF DI(2BENZYLTHIOETHYLAMMONIUM), 5-P-TOLUENSULFONAMIDE-3-THIA-HEXANEDIOATE OF DI(2BENZYLTHIOETHYLAMMONIUM), 5-P-ACETAMIDOBENZENESULFONAMIDO-3-THIA-HEXANEDIOATE OF DI-(2-BENZYLTHIOETHYLAMMONIUM), 5-P-ACETAMIDOBENZAMIDO-3-THIA-HEXANEDIOATE OF DI (2BENZYLTHIOETHYLAMMONIUM), 2-ACETAMIDO-4-THIA-HEPTANEDIOATE OF DI(2-METHYLTHIOETHYLAMMONIUM), 2-AMINO-4-THIA DECANEDIOATE OF 2BENZYLTHIOETHYLAMMONIUM, 5-AMINO-3-THIA HEXANEDIOATE OF 2BENZYLTHIOPROPYLAMMONIUM, 5-AMINO-3-THIA HEXANEDIOATE OF 2METHYLPROPYLAMMONIUM, 5-AMINO-3-THIA HEXANEDIOATE OF 2PHENYLTHIOETHYLAMMONIUM, 5-AMINO-3-THIA HEXANEDIOATE OF 2-TBUTYLTHIOETHYLAMMONIUM, 5-AMINO-3-THIA HEXANEDIOATE OF 2-TRITYLTHIOETHYLAMMONIUM, 5-AMINO-3-THIA HEXANEDIOATE OF 2-(2-BUTENYLTHIO) ETHYLAMMONIUM, 5-AMINO-3-THIA HEXANEDIOATE OF 2-(HYDROXYETHYLTHIO)ETHYLAMMONIUM, 5-AMINO-3-THIA HEXANEDIOATE OF 2-(2,3DIHYDROXYPROPYLTHIO) ETHYLAMMONIUM, 3-BENZYLTHIO-2-PHENYLACETAMIDO PROPIONATE OF 2METHYLTHIOETHYLAMMONIUM, 2-ACETAMIDO-3-TRITYLTHIOPROPIONATE OF 2METHYLTHIOETHYLAMMONIUM, 2-ACETAMIDO-3-BENZHYDRYLTHIO PROPIONATE OF 2METHYLTHIOETHYLAMMONIUM, 5-AMINO-3-THIA HEXANEDIOATE OF 6-METHANESULFONAMIDE-6ETHOXY CARBONYL-4-THIA HEXYLAMMONIUM, 2-ACETAMIDO-4-THIA-NONANEDIOATE OF 2,2''-THIO BIS (ETHYLAMMONIUM), DI-(B-BENZYLTHIOETHYLAMMONIUM) 5-P-ACETAMIDO-3-THIAHEXANEDIOATE, 5-AMINO-3-THIA ACID HEXANEDIOATE OF 2-OCTADECYLTHIO ETHYLAMMONIUM, 2-AMINO-4-THIA HEPTANEDIOATE OF 2-UNDERCENYLTHIO ETHYLAMMONIUM, 2-AMINO-4-THIA NONADEODIATE OF 2-(3-HYDROXYPROPYLTHIO) ETHYLAMMONIUM, DI-(5-AMINO-3-THIA HEXANEDIOATE) OF 3-THIA-1,6HEXANEDIAMMONIUM, 2-AMINO-4-THIA OCTANEDIOATE OF 2-(B-UREIDO ETHYLTHIO)ETHYLAMMONIUM, 5-AMINO-3-THIA HEXANEDIOATE OF 2-(3-METHANESULFONAMIDO PROPYLTHIO) ETHYLAMMONIUM, 5-AMINO-3-THIA HEXANEDIOATE OF 2-(P-PHENYLBENZYLTHIO) ETHYLAMMONIUM, 5-TETRADECANAMIDO-THIA- HEXANEDIOATE OF DI(2-BHYDROXYETHYL THIO ETHYLAMMONIUM), 2-CROTONAMIDO-4-THIA HEPTANEDIOATE OF DI(2-TERTIOBUTYLTHIO ETHYLAMMONIUM), 2-BUTANESULFONAMIDO-4-THIA OCTANEDIOATE OF 2,2''-(2,3DIHYDROXY-1,4-BUTANEDIYL DITHIO) DIETHYLAMMONIUM, 2-FORMAMIDO-3-(PROPYN-2-YLTHIO) PROPIONATE OF 3-(1NAPTHYL THIO) PROPYLAMMONIUM, 3-METHYLTHIO-2-TRIFLUOROACETAMINO PROPIONATE OF 2OLEYLTHIO ETHYLAMMONIUM, 2-O-CHLOROBENZYLTHIOMETHYL-3-AZA--4-OXO HEPTANEDIOATE OF 5,5''-SULFONYL BIS (3-THIA PENTYLAMMONIUM), 2-ACETAMINO-3-P-METHYLTHIOPHENYLTHIO PROPIONATE OF 2(2,4,6-TRIMETHYL BENZYLTHIO) ETHYLAMMONIUM, 5-AMINO-3-THIA HEXANEDIOATE OF 2(3,4-DICHLOROBENZYLTHIO) ETHYLAMMONIUM, 2-BUTYRAMIDO-3-ISOPROPYLTHIO PROPIONATE OF 2-(2,6-DICHLORO BENZYLTHIO) ETHYLAMMONIUM, 2-ACCTAMIDO-3-THIA HEPTANEDIOATE OF 2-PFLUOROBENZYLTHIO ETHYLAMMONIUM, 6-AMINO-3-THIA HEPTANEDIOATE OF 2-PDIMETHYLAMINOBENYLTHIO ETHYLAMMONIUM, 2-HEXANAMIDO-DI-(P-METHOXPHENYL)-3-METHYLTHIO PROPIONATE OF 2-(2,3-DIHYDROXY PROPYLTHIO) ETHYLAMMONIUM, 5-AMINO-3-THIA HEXANEDIOATE OF 2-(P-BROMOBENzYLTHIO) ETHYLAMMONIIUM, 5-AMINO-3-THIA HEXANEDIOATE OF 2-(P-BROMOBENXYLTHIO) -ETHYLAMMONIUM, 5-ACETAMIDO-3-THIA HEXANEDIOATE OF DI-2-(2,4DICHLOROBENZYLTHIO) ETHYLAMMONIUM, AND 2-ACETAMIDO-3-P-FLUOROBENZYLTHIO PROPIONATE OF 2HEXADECYLTHIO ETGHALAMMONIUM.

Claim 3

A cosmetic composition for topical application to human scalp and skin characterized by an excessive secretion of sebum to improve the condition thereof by reducing said excessive secretion of sebum comprising a solution in a solvent selected from the group consisting of water, lower alkanol and an aqueous solution of lower alkanol of 0.1 to 5 percent by weight of an active compound selected from the group consisting of: 5-amino-3-thia hexanedioate of 2-benzylthioethylammonium, 5-acetamido-3-thia-hexanedioate of di(2-benzylthio-ethylammonium), 5-amino-3-thia hexanedioate of 2-(3-alanylthio) ethylammonium, 5-amino-3-thia hexanedioate of 2-metHylthioethylammonium, 5-amino-3-thia hexanedioate of 3-benzylthiopropylammonium, 2-amino-4-thia heptanedioate of 2-benzylthioethylammonium, 5-amino-3-thia hexanedioate of 2-(2,2,-dimethoxyethylthio)-ethylammonium, 2-acetamido-3-benzylthio-propionate of 2-methylthioethylammonium, 5-benzamido-3-thia-hexanedioate of di(2-benzylthioethylammonium), 5-p-toluenesulfonamido-3-thia-hexanedioate of di(2-benzylthioethylammonium), 5-p-acetamidobenzenesulfonamido-3-thia-hexanedioate of di- (2-benzylthioethylammonium), 5-p-acetamidobenzamido-3-thia-hexanedioate of di- (2-benzylthioethylammonium), 2-acetamido-4-thia-heptanedioate of di(2-methylthio-ethylammonium), 2-amino-4-thia decanedioate of 2-benzylthioethylammonium, 5-amino-3-thia hexanedioate of 2-benzylthiopropylammonium, 5-amino-3-thia hexanedioate of 2-benzylthio-2-methylpropylammonium, 5-amino-3-thia hexanedioate of 2-phenylthioethylammonium, 5-amino-3-thia hexanedioate of 2-t-butylthioethylammonium, 5-amino-3-thia hexanedioate of 2-tritylthioethylammonium, 5-amino-3-thia hexanedioate of 2-(2-butenylthio) ethylammonium, 5-amino-3-thia hexanedioate of 2-(2-hydroxyethylthio)-ethylammonium, 5-amino-3-thia hexanedioate of 2-(2,3-dihydroxypropylthio) ethylammonium, 3-benzylthio-2-phenylacetamido propionate of 2-methylthioethylammonium, 2-acetamido-3-tritylthiopropionate of 2-methylthioethylammonium, 2-acetamido-3-benzhydrylthio propionate of 2-methylthioethylammonium, 5-amino-3-thia hexanedioate of 6-methanesulfonamido-6-ethoxy carbonyl-4-thia hexylammonium, 2-acetamido-4-thia-nonanedioate of 2,2''-thio bis (ethylammonium), di-( Beta -benzylthioethylammonium) 5-p-acetamido-3-thia-hexanedioate, 5-amino-3-thia acid hexanedioate of 2-octadecylthio ethylammonium, 2-amino-4-thia heptanedioate of 2-undecenylthio ethylammonium, 2-amino-4-thia nonanedioate of 2-(3-hydroxypropylthio) ethylammonium, di-(5-amino-3-thia hexanedioate) of 3-thia-1,6-hexanediammonium, 2-amino-4-thia octanedioate of 2-( Beta -ureido ethylthio)-ethylammonium, 5-amino-3-thia hexanedioate of 2-(3-methanesulfonamido propylthio) ethylammonium, 5-amino-3-thia hexanedioate of 2-(p-phenylbenzylthio) ethylammonium, 5-tetradecanamido-3-thia hexanedioate of di(2- Beta -hydroxyethyl thio ethylammonium), 2-crotonamido-4-thia heptanedioate of di(2-tertiobutylthio ethylammonium), 2-butanesulfonamido-4-thia octanedioate of 2,2''-(2,3-dihydroxy-1,4-butanediyl dithio) diethylammonium, 2-formamido-3-(propyn-2-ylthio) propionate of 3-(1-naphthyl thio) propylammonium, 3-methylthio-2-trifluoroacetamido propionate of 2-oleylthio ethylammonium, 2-o-chlorobenzylthiomethyl-3-aza-4-oxo heptanedioate of 5,5''-sulfonyl bis (3-thia pentylammonium), 2-acetamido-3-p-methylthiophenylthio propionate of 2-(2,4,6-trimethyl benzylthio) ethylammonium, 5-amino-3-thia hexanedioate of 2-(3,4-dichlorobenzylthio) ethylammonium, 2-butyramido-3-isopropylthio propionate of 2-(2,6-dichloro benzylthio) ethylammonium, 2-acetamido-3-(3-alanylthio) propionate of 2-m-fluorobenzylthio ethYlammonium, 6-amino-3-thia heptanedioate of 2-p-dimethylaminobenzylthio ethylammonium, 2-hexanamido-di-(p-methoxyphenyl)-3-methylthio propionate of 2-(2,3-dihydroxy propylthio) ethylammonium, 5-amino-3-thia hexanedioate of 2-(o-chlorobenzylthio) ethylammonium, 5-amino-3-thia hexanedioate of 2-(p-bromobenzylthio) ethylammonium, 5-acetamido-3-thia hexanedioate of di-2-(2,4-dichlorobenzylthio) ethylammonium, and 2-acetamido-3-p-fluorobenzylthio propionate of 2-hexadecylthio ethylammonium.

Claim 4

A cosmetic composition for topical application to human scalp and skin characterized by an excessive secretion of sebum to improve the condition thereof by reducing said excessive secretion of sebum comprising a solution in a solvent selected from the group consisting of water, lower alkanol and an aqueous solution of lower alkanol of 0.1 to 5 percent by weight of an active compound selected from the group consisting of: 5-amino-3-thia hexanedioate of 2-benzylthioethylammonium, 5-acetamido-3-thia-hexanedioate of di(2-benzylthio-ethylammonium), 5-amino-3-thia hexanedioate of 2-(3-alanylthio) ethylammonium, 5-amino-3-thia hexanedioate of 2-metHylthioethylammonium, 5-amino-3-thia hexanedioate of 3-benzylthiopropylammonium, 2-amino-4-thia heptanedioate of 2-benzylthioethylammonium, 5-amino-3-thia hexanedioate of 2-(2,2,-dimethoxyethylthio)-ethylammonium, 2-acetamido-3-benzylthio-propionate of 2-methylthioethylammonium, 5-benzamido-3-thia-hexanedioate of di(2-benzylthioethylammonium), 5-p-toluenesulfonamido-3-thia-hexanedioate of di(2-benzylthioethylammonium), 5-p-acetamidobenzenesulfonamido-3-thia-hexanedioate of di- (2-benzylthioethylammonium), 5-p-acetamidobenzamido-3-thia-hexanedioate of di- (2-benzylthioethylammonium), 2-acetamido-4-thia-heptanedioate of di(2-methylthio-ethylammonium), 2-amino-4-thia decanedioate of 2-benzylthioethylammonium, 5-amino-3-thia hexanedioate of 2-benzylthiopropylammonium, 5-amino-3-thia hexanedioate of 2-benzylthio-2-methylpropylammonium, 5-amino-3-thia hexanedioate of 2-phenylthioethylammonium, 5-amino-3-thia hexanedioate of 2-t-butylthioethylammonium, 5-amino-3-thia hexanedioate of 2-tritylthioethylammonium, 5-amino-3-thia hexanedioate of 2-(2-butenylthio) ethylammonium, 5-amino-3-thia hexanedioate of 2-(2-hydroxyethylthio)-ethylammonium, 5-amino-3-thia hexanedioate of 2-(2,3-dihydroxypropylthio) ethylammonium, 3-benzylthio-2-phenylacetamido propionate of 2-methylthioethylammonium, 2-acetamido-3-tritylthiopropionate of 2-methylthioethylammonium, 2-acetamido-3-benzhydrylthio propionate of 2-methylthioethylammonium, 5-amino-3-thia hexanedioate of 6-methanesulfonamido-6-ethoxy carbonyl-4-thia hexylammonium, 2-acetamido-4-thia-nonanedioate of 2,2''-thio bis (ethylammonium), di-( Beta -benzylthioethylammonium) 5-p-acetamido-3-thia-hexanedioate, 5-amino-3-thia acid hexanedioate of 2-octadecylthio ethylammonium, 2-amino-4-thia heptanedioate of 2-undecenylthio ethylammonium, 2-amino-4-thia nonanedioate of 2-(3-hydroxypropylthio) ethylammonium, di-(5-amino-3-thia hexanedioate) of 3-thia-1,6-hexanediammonium, 2-amino-4-thia octanedioate of 2-( Beta -ureido ethylthio)-ethylammonium, 5-amino-3-thia hexanedioate of 2-(3-methanesulfonamido propylthio) ethylammonium, 5-amino-3-thia hexanedioate of 2-(p-phenylbenzylthio) ethylammonium, 5-tetradecanamido-3-thia hexanedioate of di(2- Beta -hydroxyethyl thio ethylammonium), 2-crotonamido-4-thia heptanedioate of di(2-tertiobutylthio ethylammonium), 2-butanesulfonamido-4-thia octanedioate of 2,2''-(2,3-dihydroxy-1,4-butanediyl dithio) diethylammonium, 2-formamido-3-(propyn-2-ylthio) propionate of 3-(1-naphthyl thio) propylammonium, 3-methylthio-2-trifluoroacetamido propionate of 2-oleylthio ethylammonium, 2-o-chlorobenzylthiomethyl-3-aza-4-oxo heptanedioate of 5,5''-sulfonyl bis (3-thia pentylammonium), 2-acetamido-3-p-methylthiophenylthio propionate of 2-(2,4,6-trimethyl benzylthio) ethylammonium, 5-amino-3-thia hexanedioate of 2-(3,4-dichlorobenzylthio) ethylammonium, 2-butyramido-3-isopropylthio propionate of 2-(2,6-dichloro benzylthio) ethylammonium, 2-acetamido-3-(3-alanylthio) propionate of 2-m-fluorobenzylthio ethYlammonium, 6-amino-3-thia heptanedioate of 2-p-dimethylaminobenzylthio ethylammonium, 2-hexanamido-di-(p-methoxyphenyl)-3-methylthio propionate of 2-(2,3-dihydroxy propylthio) ethylammonium, 5-amino-3-thia hexanedioate of 2-(o-chlorobenzylthio) ethylammonium, 5-amino-3-thia hexanedioate of 2-(p-bromobenzylthio) ethylammonium, 5-acetamido-3-thia hexanedioate of di-2-(2,4-dichlorobenzylthio) ethylammonium, and 2-acetamido-3-p-fluorobenzylthio propionate of 2-hexadecylthio ethylammonium.

Claim 5

The composition of claim 1 wherein said compound is 5-amino 3-thia hexanedioate of 2-benzylthio-ethylammonium.

Claim 6

The composition of claim 1 wherein said active compound is present in amounts of 0.75-3 percent by weight of said composition.