Patent US3879393A successfully refreshed from Google Patents.
US3879393A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Derivatives of 1,3-disubstituted 2,4(1h,3h)-quinazolinediones
Assignee: Bayer Corp
•
Filing: 1973-06-18
•
Granted: 1975-04-22
•
Expires: 1993-06-18
Abstract
Abstract The disclosed derivatives of 1,3-disubstituted 2,4 (1H,3H)quinazolinediones produce vasodilation in experimental animals. The 1,3-disubstitutions include, among others, 1(alky(alkylamino))-, 1-(alkylpiperidyl)-, 3-(alkyl(alkylamino))-, 3-(alkyl(4-phenyl-1-piperidyl)-, and 3-(alkyl(4-phenyl-1piperazinyl))-moieties. In the latter two substituents the phenyl group optionally is substituted with halogeno or loweralkyl groups. Additionally, the compounds optionally are substituted at carbon atoms 5 through 8 of the quinazolinedione nucleus with halogeno, nitro, alkoxy, and alkylamido substituents.
Inventors
- 👤 Herbert John Havera
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 13:29
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/06
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
5 words
A COMPOUND HAVING THE FORMULA
Claim 2
Dependent Claim
5 words
A COMPOUND HAVING THE FORMULA
Claim 3
Dependent Claim
5 words
A compound having the formula
Claim 4
Dependent Claim
5 words
A compound having the formula
Claim 5
Dependent Claim
10 words
The compound as in claim 1, 1-(3-(N,N-dimethylamino)-propyl)-3(3-(4-m-chlorophenyl-1-piperazyl)propyl) -2,4-(1H, 3H)quinazolinedione dihydrochloride.
Claim 6
Dependent Claim
9 words
The compound as in claim 1, 1-(3-(N,N-dimethylamino)-propyl)-3(3-(4-phenyl-1 -piperazinyl)propyl)2,4(1H,3H)-quinazolinedione dehydrochloride.
Claim 7
Dependent Claim
9 words
The compound as in claim 1, 1-(3-(N,N-dimethylamino)-propyl)-3(3-(4-phenyl-1-piperidyl)propyl) -2,4(1H,3H)-quinazolinedione dihydrochloride.
Claim 8
Dependent Claim
9 words
The compound as in claim 1, 1-(3-(N,N-dimethylamino)-propyl)-3(2-(4-phenyl-1 -piperazinyl)ethyl)2,4(1H,3H)-quinazolinedione dioxalate.
Claim 9
Dependent Claim
9 words
The compound as in claim 1, 1-(3-(N,N-dimethylamino)-propyl)-3-(6-(4-phenyl-1-piperazinyl)hexyl) -2,4(1H,3H)-quinazolinedione dioxalate.
Claim 10
Dependent Claim
9 words
The compound as in claim 1, 61-(3-(N,N-di-methylamino)propyl)-3-(3-(4-phenyl-1-piperazyl) -2,4-(1H3H)quinazolinedione dioxalate.
Claim 11
Dependent Claim
11 words
The compound as in claim 1, 6-nitro-1-(3-(N,N-di-methylamino)propyl)-3-(3-(4-phenyl-1piperazinyl) -propyl)-2,4(1H, 3H)quinazolinedione dihydrochloride hydrate.
Claim 12
Dependent Claim
10 words
The compound is as in claim 1, 1-3-(1-piperidyl)-propyl)-3-(3-(4-phenyl-1-piperazinyl)propyl)-2,4-(1H,3H) -quinazolinedione dioxalate.
Claim 13
Dependent Claim
9 words
The compound as in claim 1, 1-(2-(N,N-dimethylamino)-ethyl)-3-(3-(4-phenyl-1 -piperazinyl(propyl)2,4(1H,3H)-quinazolinedione dioxalate.
Claim 14
Dependent Claim
11 words
The compound as in claim 1, 6-acetamido-1-(3-N,N-dimethylamino)propyl)-3-(3-(4-phenyl-1-piperazinyl) -propyl)-2, 4(1H,3H)quinazolinedione dioxalate hydrate.,
Claim 15
Dependent Claim
10 words
The compound as in claim 1, 1-(3-(N,N-diethylamino)-propyl)-3-(3-(4-phenyl-1 -piperazinyl)propyl)2,4(1H,3H)-quinazoLinedione dioxalate hydrate.
Claim 16
Dependent Claim
9 words
The compound as in claim 1, 6,7-dimethoxy-1(3-(N,N-dimethylamino)propyl)-3-(3-(4-phenyl-1-piperazyl) -propyl)-2,4-(1H,3H)quinazolinedione dihydrochlroide.
Claim 17
Dependent Claim
8 words
The compound as in claim 1, 1-(3-(N,N-dimethylamino)-propyl)-3-(3-4o-methylphenyl-1-piperazinyl)-propyl)-2,3(1H, 3H)quinazolinedione.
Claim 18
Dependent Claim
11 words
The compound as in claim 1, 1-(3-(N,N-dimethylamino)-propyl)-3-(7-(4-phenyl-1-piperazinyl)heptyl)-2,4 -(1H, 3H)Quinazolinone dioxalate methanolate.
Claim 19
Dependent Claim
9 words
The compound as in claim 1, 1-(3-(1-piperidyl)propyl)-3-(6-(4-phenyl-1-piperazinyl)hexyl) -2,4(1H,3H)quinazolinedione dioxalate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-04-21 | 1978-10-21 | 1979-04-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-04-21 | 1982-10-21 | 1983-04-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-04-21 | 1986-10-21 | 1987-04-22 | $7700.00 | Window Closed / Lapsed |