Patent US3876786A successfully refreshed from Google Patents.
US3876786A
Expired / Lapsed
US
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6-(substituted phenyl)-4,5-dihydro-3(2h)-pyridazinones for lowering blood pressure in mammals
Assignee: Wyeth Holdings LLC
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Filing: 1973-08-27
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Granted: 1975-04-08
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Expires: 1993-08-27
Abstract
Abstract This disclosure describes compounds of the class of 6(substituted-phenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinones useful as hypotensive agents.
Inventors
- 👤 Francis Joseph Mcevoy
- 👤 Jr George Rodger Allen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 16:03
CPC Classifications
C; C07; C07C; C07C255/00
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
33 words
A THERAPEUTIC COMPOSITION IN DOSAGE UNIT FORM USEFUL FOR LOWERING BLOOD PRESSURE IN MAMMALS COMPRISING FROM ABOUT 50 MG. TO ABOUT 1.0 GRAM PER DAILY DOSAGE UNIT OF 6-(N-ETHYLP-ACETAMIDOPHENYL)-5-METHYL-4,5-DIHYDRO-3(2H)PYRIDAZINONE AND A PHARMACEUTICAL CARRIER.
Claim 2
Dependent Claim
33 words
A THERAPEUTIC COMPOSITION IN DOSAGE UNIT FORM USEFUL FOR LOWERING BLOOD PRESSURE IN MAMMALS COMPRISING FROM ABOUT 50 MG. TO ABOUT 1.0 GRAM PER DAILY DOSAGE UNIT OF 6-(N-ETHYLP-ACETAMIDOPHENYL)-5-METHYL-4,5-DIHYDRO-3(2H)PYRIDAZINONE AND A PHARMACEUTICAL CARRIER.
Claim 3
Dependent Claim
33 words
A therapeutic composition in dosage unit form useful for lowering blood pressure in mammals comprising from about 50 mg. to about 1.0 gram per daily dosage unit of 6-(N-methyl-p-acetamidophenyl)-2,5-dimethyl-4,5-dihydro-3(2H)-pyridazinone and a pharmaceutical carrier.
Claim 4
Dependent Claim
33 words
A therapeutic composition in dosage unit form useful for lowering blood pressure in mammals comprising from about 50 mg. to about 1.0 gram per daily dosage unit of 6-(N-methyl-p-acetamidophenyl)-2,5-dimethyl-4,5-dihydro-3(2H)-pyridazinone and a pharmaceutical carrier.
Claim 5
Dependent Claim
47 words
A therapeutic composition in dosage unit form useful for lowering blood pressure in mammals comprising from about 50 mg. to about 1.0 gram per daily dosage unit of a compound selected from the group consisting of 6-(p-methylaminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone and the non-toxic acid-addition salts thereof, and a pharmaceutical carrier.
Claim 6
Dependent Claim
47 words
A therapeutic composition in dosage unit form useful for lowering blood pressure in mammals comprising from about 50 mg. to about 1.0 gram per daily dosage unit of a compound selected from the group consisting of 6-(p-methylaminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone and the non-toxic acid-addition salts thereof, and a pharmaceutical carrier.
Claim 7
Dependent Claim
47 words
A therapeutic composition in dosage unit form useful for lowering blood pressure in mammals comprising from about 50 mg. to about 1.0 gram per daily dosage unit of a compound selected from the group consisting of 6-(p-methylaminophenyl)-2,5-dimethyl-4,5-dihydro-3(2H)-pyridazinone and the non-toxic acid-addition salts thereof, and a pharmaceutical carrier.
Claim 8
Dependent Claim
47 words
A therapeutic composition in dosage unit form useful for lowering blood pressure in mammals comprising from about 50 mg. to about 1.0 gram per daily dosage unit of a compound selected from the group consisting of 6-(p-methylaminophenyl)-2,5-dimethyl-4,5-dihydro-3(2H)-pyridazinone and the non-toxic acid-addition salts thereof, and a pharmaceutical carrier.
Claim 9
Dependent Claim
47 words
A therapeutic composition in dosage unit form useful for lowering blood pressure in mammals comprising from about 50 mg. to about 1.0 gram per daily dosage unit of a compound selected from the group consisting of 6-(p-ethylaminophenyl)-2,5-dimethyl-4,5-dihydro-3(2H)-pyridazinone and the non-toxic acid-addition salts thereof, and a pharmaceutical carrier.
Claim 10
Dependent Claim
47 words
A therapeutic composition in dosage unit form useful for lowering blood pressure in mammals comprising from about 50 mg. to about 1.0 gram per daily dosage unit of a compound selected from the group consisting of 6-(p-ethylaminophenyl)-2,5-dimethyl-4,5-dihydro-3(2H)-pyridazinone and the non-toxic acid-addition salts thereof, and a pharmaceutical carrier.
Claim 11
Dependent Claim
47 words
A therapeutic composition in dosage unit form useful for lowering blood pressure in mammals comprising from about 50 mg. to about 1.0 gram per daily dosage unit of a compound selected from the group consisting of 6-(p-ethylaminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone and the non-toxic acid-addition salts thereof, and a pharmaceutical carrier.
Claim 12
Dependent Claim
47 words
A therapeutic composition in dosage unit form useful for lowering blood pressure in mammals comprising from about 50 mg. to about 1.0 gram per daily dosage unit of a compound selected from the group consisting of 6-(p-ethylaminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone and the non-toxic acid-addition salts thereof, and a pharmaceutical carrier.
Claim 13
Independent Claim
49 words
The method of lowering blood pressure in a mammal which comprises administering internally to said mammal an effective amount of 6-(N-ethyl-p-acetamidophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone in association with a pharmaceutical carrier to provide a daily dosage of from about one mg. to about 15 mg. per kilogram of body weight of said mammal.
Claim 14
Independent Claim
49 words
The method of lowering blood pressure in a mammal which comprises administering internally to said mammal an effective amount of 6-(N-ethyl-p-acetamidophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone in association with a pharmaceutical carrier to provide a daily dosage of from about one mg. to about 15 mg. per kilogram of body weight of said mammal.
Claim 15
Independent Claim
50 words
The method of lowering blood pressure in a mammal which comprises administering internally to said mammal an effective amount of 6-(N-methyl-p-acetamidophenyl)-2,5-dimethyl-4,5-dihydro-3(2H) -pyridazinone in association with a pharmaceutical carrier to provide a daily dosage of from about one mg. to about 15 mg. per kilogram of body weight of said mammal.
Claim 16
Independent Claim
50 words
The method of lowering blood pressure in a mammal which comprises administering internally to said mammal an effective amount of 6-(N-methyl-p-acetamidophenyl)-2,5-dimethyl-4,5-dihydro-3(2H) -pyridazinone in association with a pharmaceutical carrier to provide a daily dosage of from about one mg. to about 15 mg. per kilogram of body weight of said mammal.
Claim 17
Independent Claim
63 words
The method of lowering blood pressure in a mammal which comprises administering internally to said mammal an effective amount of a compound selected from the group consisting of 6-(p-methylaminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone and the non-toxic acid-addition salts thereof, in association with a pharmaceutical carrier to provide a daily dosage of from about one mg. to about 15 mg. per kilogram of body weight of said mammal.
Claim 18
Independent Claim
63 words
The method of lowering blood pressure in a mammal which comprises administering internally to said mammal an effective amount of a compound selected from the group consisting of 6-(p-methylaminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone and the non-toxic acid-addition salts thereof, in association with a pharmaceutical carrier to provide a daily dosage of from about one mg. to about 15 mg. per kilogram of body weight of said mammal.
Claim 19
Independent Claim
63 words
The method of lowering blood pressure in a mammal which comprises administering internally to said mammal an effective amount of a compound selected from the group consisting of 6-(p-methylaminophenyl)-2,5-dimethyl-4,5-dihydro-3(2H)-pyridazinone and the non-toxic acid-addition salts thereof, in association with a pharmaceutical carrier to provide a daily dosage of from about one mg. to about 15 mg. per kilogram of body weight of said mammal.
Claim 20
Independent Claim
63 words
The method of lowering blood pressure in a mammal which comprises administering internally to said mammal an effective amount of a compound selected from the group consisting of 6-(p-methylaminophenyl)-2,5-dimethyl-4,5-dihydro-3(2H)-pyridazinone and the non-toxic acid-addition salts thereof, in association with a pharmaceutical carrier to provide a daily dosage of from about one mg. to about 15 mg. per kilogram of body weight of said mammal.
Claim 21
Independent Claim
63 words
The method of lowering blood pressure in a mammal which comprises administering internally to said mammal an effective amount of a compound selected from the group consisting of 6-(p-ethylaminophenyl)-2,5-dimethyl-4,5-dihydro-3(2H)-pyridazinone and the non-toxic acid-addition salts thereof, in association with a pharmaceutical carrier to provide a daily dosage of from about one mg. to about 15 mg. per kilogram of body weight of said mammal.
Claim 22
Independent Claim
63 words
The method of lowering blood pressure in a mammal which comprises administering internally to said mammal an effective amount of a compound selected from the group consisting of 6-(p-ethylaminophenyl)-2,5-dimethyl-4,5-dihydro-3(2H)-pyridazinone and the non-toxic acid-addition salts thereof, in association with a pharmaceutical carrier to provide a daily dosage of from about one mg. to about 15 mg. per kilogram of body weight of said mammal.
Claim 23
Independent Claim
63 words
The method of lowering blood pressure in a mammal which comprises administering internally to said mammal an effective amount of a compound selected from the group consisting of 6-(p-ethylaminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone and the non-toxic acid-addition salts thereof, in association with a pharmaceutical carrier to provide a daily dosage of from about one mg. to about 15 mg. per kilogram of body weight of said mammal.
Claim 24
Independent Claim
63 words
The method of lowering blood pressure in a mammal which comprises administering internally to said mammal an effective amount of a compound selected from the group consisting of 6-(p-ethylaminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone and the non-toxic acid-addition salts thereof, in association with a pharmaceutical carrier to provide a daily dosage of from about one mg. to about 15 mg. per kilogram of body weight of said mammal.
References Cited (Backward Citations)
US3475431A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-04-07 | 1978-10-07 | 1979-04-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-04-07 | 1982-10-07 | 1983-04-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-04-07 | 1986-10-07 | 1987-04-08 | $7700.00 | Window Closed / Lapsed |