Patent US3875152A successfully refreshed from Google Patents.
US3875152A
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Intermediates for producing semi-synthetic cephalosporins and methods of production
Assignee: Wyeth LLC
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Filing: 1973-07-11
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Granted: 1975-04-01
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Expires: 1993-07-11
Abstract
Abstract Novel 6-APA, 7-ACA, and 7-ADCA derivatives are described which comprise phosphorylated derivatives of 6-APA, 7-ACA, or 7-ADCA and the corresponding acylated derivatives thereof. The novel compounds are prepared by the reaction of 6-APA, 7-ACA, 7-ADCA or a salt thereof with a phosphorus halide in the presence of an acid acceptor and subsequently acylating the thus formed phosphorylated compound, to form a phosphorylated acylated derivative which upon hydrolysis with water splits off the protective group(s) to provide the corresponding semi-synthetic penicillin or cephalosporin having useful antibacterial activity.
Inventors
- 👤 John H Sellstedt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 22:05
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/547; C07F9/6561; C07F9/65611; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
5 words
A COMPOUND OF THE FORMULA:
Claim 2
Dependent Claim
5 words
A COMPOUND OF THE FORMULA:
Claim 3
Dependent Claim
8 words
A compound according to claim 1 which is:
Claim 4
Dependent Claim
8 words
A compound accroding to claim 1 which is:
Claim 5
Independent Claim
10 words
A method wHich comprises reacting a compound of the formula:
Claim 6
Independent Claim
10 words
A method wHich comprises reacting a compound of the formula:
Claim 7
Dependent Claim
21 words
A process according to claim 4 wherein R5 and R6 are joined together with the phosphorus atom to form the ring:
Claim 8
Dependent Claim
71 words
A process according to claim 4 which comprises reacting a cephalosporin selected from the class consisting of 7amino-cephalosporanic acid and 7-amino-3-desacetoxy cephalosporanic acid under anhydrous conditions and in the presence of an acid binding agent with a 2-halo-1,3,2-dioxaphospholane or a lower alkyl substituted derivative thereof at a temperature between about -10*C. and 25*C, the molar ratio of said 2-halo-1,3,2-dioxaphospholane are lower alkyl derivative thereto to said cephalosporin being at least 1:1.
References Cited (Backward Citations)
US3809699A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-03-31 | 1978-09-30 | 1979-04-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-03-31 | 1982-09-30 | 1983-04-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-03-31 | 1986-09-30 | 1987-04-01 | $7700.00 | Window Closed / Lapsed |