Pyrido(2, 3d) pyrimidines

Abstract

Abstract WHEREIN R2 represents a pyridyl, chloropyridyl, sulfonamidopyridyl, sulfonamidochloropyridyl, phenyl, trifluoromethylphenyl, chlorophenyl, nitrophenyl, sulfonamidophenyl, sulfonamidochlorophenyl, methylchlorophenyl, aminophenyl, alkylaminophenyl, dialkylaminophenyl, acylaminophenyl, alkoxyphenyl or pyrimidyl radical; R1, when R3 is nul, represents hydrogen - provided that R2 is different from a 3''-pyridyl radical - a halogen, a substituted or not linear or branched alkyl radical of 1 to 5 carbon atoms, a linear or branched lower alkenyl radical comprising only one carbon-carbon double bond, an alkoxy radical, an alkylthio radical, an amino radical provided that R2 is different from a 3''-pyridyl radical, a mono- or disubstituted amino radical, a carbohydrazide, a carbo-N2-alkylhydrazide, a hydrazino radical, a N2-alkylhydrazino radical, a mono- or disubstituted carboxamide, a substituted or not carboxyl radical, a heterocyclic radical, such as morpholino, piperidino, piperazino, which is substituted or not, a sulfonic radical a substituted or not sulfonamide, or an oxo or thio group when R3 is hydrogen (except when R1 is an oxo group and R2 is phenyl), an hydroxy radical, a linear or branched alkyl radical, substituted or not, a trifluoromethyl radical, a linear or branched alkenyl radical, a cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, pyridyl, pyrimidyl, substituted or not benzyl, substituted or not phenyl radical. Said compounds are particularly useful as neuroleptic and tranquillizing agents. Substituted derivatives of pyrido (2,3d) pyrimidine, having the general formula:

Inventors

• 👤 Jean P Osselaere
• 👤 Charles L Lapiere

Bibliographic Details