Patent US3868460A successfully refreshed from Google Patents.
US3868460A
Expired / Lapsed
US
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Therapeutic compositions and method
Assignee: C.H. Boehringer Sohn AG and Co KG
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Filing: 1973-10-23
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Granted: 1975-02-25
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Expires: 1993-10-23
Abstract
Abstract WHEREIN R is selected from the group consisting of -(CH2)x-CN where x is an integer from 0 to 3, COOH and COOR'' where R'' is alkyl of one to four carbon atoms: R1 is selected from the group consisting of hydrogen, alkoxy and alkylthio of one to four carbon atoms, -CN and alkenyl and alkynyl of two to four carbon atoms and R2 is selected from the group consisting of hydrogen, halogen and alkyl and alkoxy of one to four carbon atoms, their optically active isomers and their non-toxic, pharmaceutically acceptable acid addition salts of said racemates and said optically active isomers and a major amount of a pharmaceutical carrier and a method of producing bradycardia and suppressing tachycardia effects of N-isopropyl-noradrenaline in warm-blooded animals. A composition having bradycardia and iisoproterenol antagonistic activity comprising at least one compound selected from the group consisting of racemates of 1-phenoxy-2-hydroxy-3-tert.-butylamino propanes of the formula
Inventors
- 👤 Herbert Koppe
- 👤 Albrecht Engelhardt
- 👤 Karl Zeile
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 19:38
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/135; A61K31/14; C; C07; C07D; C07D309/00; C07D309/02; C07D309/08; C07D309/10; C07D309/12
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
33 words
A COMPOSITION HAVING BRADYCARDIA AND ISOPROTERENOL ANTAGONISTIC ACTIVITY COMPRISING A SMALL BUT EFFECTIVE AMOUNT OF AT LEAST ONE ACTIVE COMPOUND SELECTED FROM THE GROUP CONSISTING OF RACEMATES OF 1-PHENOXY-2-HYDROXY-3-TERT-BUTYLAMINO PROPANES OF THE FORMULA
Claim 2
Dependent Claim
33 words
A COMPOSITION HAVING BRADYCARDIA AND ISOPROTERENOL ANTAGONISTIC ACTIVITY COMPRISING A SMALL BUT EFFECTIVE AMOUNT OF AT LEAST ONE ACTIVE COMPOUND SELECTED FROM THE GROUP CONSISTING OF RACEMATES OF 1-PHENOXY-2-HYDROXY-3-TERT-BUTYLAMINO PROPANES OF THE FORMULA
Claim 3
Dependent Claim
16 words
A composition of claim 1 wherein the amount of active ingredient is 1 to 300 mg.
Claim 4
Dependent Claim
9 words
A composition of claim 1 wherein R1 is hydrogen.
Claim 5
Dependent Claim
20 words
A composition of claim 1 wherein the active compound is 1-(2-cyano-3-methyl-phenoxy)-2-hydroxy-3-tert.-butylamino propane and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 6
Dependent Claim
20 words
A composition of claim 1 wherein the active compound is 1-(2-cyano-4-chlorophenoxy)-2-hydroxy-3-tert.-butylamino propane and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 7
Dependent Claim
20 words
A composition of claim 1 wherein the active compound is 1-(2-methyl-4-cyanophenoxy)-2-hydroxy-3-tert.-butylamino propane and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 8
Dependent Claim
20 words
A composition of claim 1 wherein the active compound is 1-(2-methoxy-4-cyanophenoxy)-2-hydroxy-3-tert.-butylamino propane and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 9
Dependent Claim
20 words
A composition of claim 1 wherein the active compound is 1-(2-methoxy-5-cyanophenoxy)-2-hydroxy-3-tert.-butylamino propane and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 10
Dependent Claim
20 words
A composition of claim 1 wherein the active compound is 1-(2-cyano-phenoxy)-2-hydroxy-3-tert.-butylamino propane and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 11
Dependent Claim
20 words
A composition of claim 1 wherein the active compound is 1-(4-cyano-phenoxy)-2-hydroxy-3-tert.-butylamino propane and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 12
Dependent Claim
20 words
A composition of claim 1 wherein the active compound is 1-(3-cyano-phenoxy)-2-hydroxy-3-tert.-butylamino propane and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 13
Independent Claim
42 words
A method producing bradycardia and suppressing tachycardiac effects of N-isopropylnoradrenaline in warm-blooded animals which comprises administEring to warm-blooded animals a safe and effective amount of at least one compound selected from the group consisting of racemates of 1-phenoxy-3-hydroxy-3-tert.-butylamino propanes of the formula
Claim 14
Independent Claim
42 words
A method producing bradycardia and suppressing tachycardiac effects of N-isopropylnoradrenaline in warm-blooded animals which comprises administEring to warm-blooded animals a safe and effective amount of at least one compound selected from the group consisting of racemates of 1-phenoxy-3-hydroxy-3-tert.-butylamino propanes of the formula
Claim 15
Dependent Claim
20 words
The method of claim 12 wherein the active compound is 1-(2-cyanophenoxy)-2-hydroxy-3-tert.-butylamino propane or its non-toxic, pharmaceutically acceptable acid addition salts.
References Cited (Backward Citations)
FR1126165A
Cited
NL6409883A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-02-24 | 1978-08-26 | 1979-02-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-02-24 | 1982-08-26 | 1983-02-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-02-24 | 1986-08-26 | 1987-02-25 | $7700.00 | Window Closed / Lapsed |