Patent US3867520A successfully refreshed from Google Patents.
US3867520A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Medicated polyamino acid film for occlusive dressing therapy
Assignee: Ajinomoto Co Inc
•
Filing: 1974-02-05
•
Granted: 1975-02-18
•
Expires: 1994-02-05
Abstract
Abstract Therapeutic agents are dissolved or otherwise dispersed in carriers which form a separate, disperse phase in films having a continuous matrix of polyamino acid. The carriers tend to migrate to the film surface when the film temperature is raised to body temperature, thereby gradually bringing the therapeutic agents to the film surface for contact with the skin or other body surface to which the film is applied as an occlusive dressing. The rate at which a therapeutic agent is released from the film can be controlled by varying the amount of carrier.
Inventors
- 👤 Shigeo Mori
- 👤 Akira Akamatsu
- 👤 Kazushi Togo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 18:13
CPC Classifications
A; A61; A61L; A61L26/00; A61L26/0061; A61L26/0076; A61L15/00; A61L15/16; A61L15/22; A61L15/26; A61L15/42; A61L15/44; A61L26/0009; A61L26/0028; A61L26/0066; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/60; A61L2300/602
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
22 words
A BODY-CONTACTING SOLID FILM FOR AN OCCLUSIVE DRESSING ESSENTIALLY CONSISTING OF A. AT LEAST ONE POLYY-A-AMINO ACID AS A SOLID, FILM-FORMING MATRIX,
Claim 2
Dependent Claim
22 words
A BODY-CONTACTING SOLID FILM FOR AN OCCLUSIVE DRESSING ESSENTIALLY CONSISTING OF A. AT LEAST ONE POLYY-A-AMINO ACID AS A SOLID, FILM-FORMING MATRIX,
Claim 3
Dependent Claim
83 words
SAID ACID BEING A HOMOPOLYMER OF AN A-AMINO ACID OF THE GROUP CONSISTING OF GLYCINE, ALANINE, PHENYLALANINE, LEUCINE, ISOLEUCINE, VALINE, NORVALINE, NORLEUCINE, METHIONINE, THE W-LOWER-ALKYL ESTERS OF GLUTAMIC ACID AND ASPARTIC ACID HAVING 1 TO 4 CARBON ATOMS IN THE LOWER ALKYL GROUP THEREOF, THE W-N-MONO-ALKANOYL DERIVATIVES OF LYSINE AND ORNITHINE HAVING 2 TO 4 CARBON ATOMS IN THE ALKANOYL GROUP, OR A COPOLYMER OF AT LEAST TWO MEMBERS OF SAID GROUP; B. A CARRIER DISPERSED IN SAID MATRIX AS A SEPARATE PHASE,;
Claim 4
Dependent Claim
83 words
SAID ACID BEING A HOMOPOLYMER OF AN A-AMINO ACID OF THE GROUP CONSISTING OF GLYCINE, ALANINE, PHENYLALANINE, LEUCINE, ISOLEUCINE, VALINE, NORVALINE, NORLEUCINE, METHIONINE, THE W-LOWER-ALKYL ESTERS OF GLUTAMIC ACID AND ASPARTIC ACID HAVING 1 TO 4 CARBON ATOMS IN THE LOWER ALKYL GROUP THEREOF, THE W-N-MONO-ALKANOYL DERIVATIVES OF LYSINE AND ORNITHINE HAVING 2 TO 4 CARBON ATOMS IN THE ALKANOYL GROUP, OR A COPOLYMER OF AT LEAST TWO MEMBERS OF SAID GROUP; B. A CARRIER DISPERSED IN SAID MATRIX AS A SEPARATE PHASE,;
Claim 5
Dependent Claim
8 words
SAID CARRIER BEING LIQUID OR SEMI-SOLID AT 37*C,
Claim 6
Dependent Claim
8 words
SAID CARRIER BEING LIQUID OR SEMI-SOLID AT 37*C,
Claim 7
Dependent Claim
51 words
THE WEIGHT OF SAID CARRIER IN SAID SEPARATE PHASE BEING AT LEAST EQUAL TO THE WEIGHT OF SAID AGENT DISPERSED IN SAID CARRIER, BUT SMALLER THAN THE WEIGHT OF SAID MATRIX, E. SAID CARRIER AND SAID AGENT BEING SUBSTANTIALLY COMPLETELY RETAINED IN SAID MATRIX FOR ONE MOTH AT TEMPERATURES BELOW 0*C.
Claim 8
Dependent Claim
51 words
THE WEIGHT OF SAID CARRIER IN SAID SEPARATE PHASE BEING AT LEAST EQUAL TO THE WEIGHT OF SAID AGENT DISPERSED IN SAID CARRIER, BUT SMALLER THAN THE WEIGHT OF SAID MATRIX, E. SAID CARRIER AND SAID AGENT BEING SUBSTANTIALLY COMPLETELY RETAINED IN SAID MATRIX FOR ONE MOTH AT TEMPERATURES BELOW 0*C.
Claim 9
Dependent Claim
24 words
SAID CARRIER BEING INSOLUBLE OR POORLY SOLUBLE IN SAID MATRIX AT 37*C, AND NON-TOXIC TO THE HUMAN BODY WHEN IN CONTACT WITH HUMAN SKIN,
Claim 10
Dependent Claim
24 words
SAID CARRIER BEING INSOLUBLE OR POORLY SOLUBLE IN SAID MATRIX AT 37*C, AND NON-TOXIC TO THE HUMAN BODY WHEN IN CONTACT WITH HUMAN SKIN,
Claim 11
Dependent Claim
24 words
said carrier being insoluble or poorly soluble in said matrix at 37*C, and non-toxic to the human body when in contact with human skin,
Claim 12
Dependent Claim
24 words
said carrier being insoluble or poorly soluble in said matrix at 37*C, and non-toxic to the human body when in contact with human skin,
Claim 13
Dependent Claim
19 words
said carrier and said agent being substantially completely retained in said matrix for one month at temperatures below 0*C.
Claim 14
Dependent Claim
19 words
said carrier and said agent being substantially completely retained in said matrix for one month at temperatures below 0*C.
Claim 15
Dependent Claim
28 words
A film as set forth in claim 1, wherein said matrix, said carrier, and said agent are chemically inert to each other at all temperatures up to 37*C.
Claim 16
Dependent Claim
63 words
the amount of said dispersed carrier being sufficient to cause a significant portion, greater than incidental traces, of said carrier to migrate to a surface of said film at 37*C; and c. a pharmaceutically active agent dispersed in said carrier in an amount sufficient to cause migration of said agent with said carrier to said surface at 37*C in a therapeutically significant amount,
Claim 17
Dependent Claim
63 words
the amount of said dispersed carrier being sufficient to cause a significant portion, greater than incidental traces, of said carrier to migrate to a surface of said film at 37*C; and c. a pharmaceutically active agent dispersed in said carrier in an amount sufficient to cause migration of said agent with said carrier to said surface at 37*C in a therapeutically significant amount,
Claim 18
Dependent Claim
63 words
THE AMOUNT OF SAID DISPERSED CARRIER BEING SUFFICIENT TO CAUSE A SIGNIFICANT PORTION, GREATER THAN INCIDENTAL TRACES, OF SAID CARRIER TO MIGRATE TO A SURFACE OF SAID FILM AT 37*C; AND C. A PHARMACEUTICALLY ACTIVE AGENT DISPERSED IN SAID CARRIER IN AN AMOUNT SUFFICIENT TO CAUSE MIGRATION OF SAID AGENT WITH SAID CARRIER TO SAID SURFACE AT 37*C IN A THERAPEUTICALLY SIGNIFICANT AMOUNT,
Claim 19
Dependent Claim
63 words
THE AMOUNT OF SAID DISPERSED CARRIER BEING SUFFICIENT TO CAUSE A SIGNIFICANT PORTION, GREATER THAN INCIDENTAL TRACES, OF SAID CARRIER TO MIGRATE TO A SURFACE OF SAID FILM AT 37*C; AND C. A PHARMACEUTICALLY ACTIVE AGENT DISPERSED IN SAID CARRIER IN AN AMOUNT SUFFICIENT TO CAUSE MIGRATION OF SAID AGENT WITH SAID CARRIER TO SAID SURFACE AT 37*C IN A THERAPEUTICALLY SIGNIFICANT AMOUNT,
Claim 20
Dependent Claim
27 words
A film as set forth in claim 2, wherein said carrier essentially consists of at least one member of the group consisting of fats, oils, and waxes.
Claim 21
Dependent Claim
20 words
A film as set forth in claim 2, wherein said carrier is unable to form ions in contact with water.
Claim 22
Dependent Claim
44 words
A film as set forth in claim 2, the amount of said carrier being sufficient to cause transfer of at least 2 percent of the weight of said agent from the interior of said film to the film surface within 24 hours at 37*C.
Claim 23
Dependent Claim
24 words
A film as set forth in claim 2, wherein said at least one polyamino acid has a degree of polymerization of at least 100.
Claim 24
Dependent Claim
22 words
A film as set forth in claim 1, wherein said poly- Alpha -amino acid has predominant repeating units of gamma -lower-alkyl glutamate.
Claim 25
Dependent Claim
29 words
A film as set forth in claim 7, wherein said poly- Alpha -amino acid is a copolymer of gamma -ethyl glutamate and valine in a mole ratio of 2:1.
References Cited (Backward Citations)
US2705705A
Cited
US2666013A
Cited
US2666012A
Cited
US2691643A
Cited
US2657972A
Cited
US2937974A
Cited
US3052655A
Cited
US3076790A
Cited
US3061512A
Cited
US3331814A
Cited
US3371069A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-02-17 | 1978-08-19 | 1979-02-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-02-17 | 1982-08-19 | 1983-02-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-02-17 | 1986-08-19 | 1987-02-18 | $7700.00 | Window Closed / Lapsed |