Fusidic acid conjugates
Abstract
Abstract The present invention relates to new conjugates of glycine and taurine with compounds of the fusidic acid series according to formulae I and II below, to methods for the preparation of such compounds, and to pharmaceutical compositions thereof. The formulae are IN WHICH OAe indicates OOC.CH3 the dotted lines between C-17 and C-20 and between C-24 and C-25 indicate that the carbon atoms in question are connected with either a single bond or a double bond, and R is hydrogen or an acetyl group. The new compounds can be used as artificial ''''bile salts'''' in bile salts deficiency states, for the prevention of cholesterol precipitation in bile and for dissolution of cholesterol gallstones in vivo. The new derivatives of fusidic acid have similar micelle-forming properties as the parent compound, but are not antibacterially active and are not metabolized, which are undesirable properties in this context.
Inventors
- 👤 Welf Von Daehne
- 👤 Wagn Ole Godtfredsen
Bibliographic Details
Claims Analysis
Total Claims: 12References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1978-02-17 | 1978-08-19 | 1979-02-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-02-17 | 1982-08-19 | 1983-02-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-02-17 | 1986-08-19 | 1987-02-18 | $7700.00 | Window Closed / Lapsed |