5beta-taurocholenic acids and 5beta-taurocholadienic acids
Abstract
Abstract 5B-TAUROCHOLENIC ACIDS WHEREIN THE DOUBLE BOND MAY BE EITHER IN THE 22-POSITION OF THE ALIPHATIC CHAIN OR WITHIN THE CHOLANE RING; AND 5B-TAUROCHOLADIENIC ACIDS WHEREIN ONE DOUBLE BOND IS IN THE 22-POSITION OF THE CHAIN AND THE SECOND IS WITHIN THE CHOLANE NUCLEUS; AND THE SALTS, ESTERS AND AMIDE DERIVATIVES THEREOF. THE INSTANT PRODUCTS MAY BE OBTAINED: (1) VIA THE REACTION OF 5B-CHOLENIC ACID OR 5B-CHOLADIENIC ACID WITH AN ALKYL HALOFORMATE IN THE PRESENCE OF A BASE TO AFFORD A 5B-CHOLENIC ALKYLCARBONIC ANHYDRIDE OR 5B-CHOLADIENIC ALKYLCARBONIC ANHYDRIDE, WHICH INTERMEDIATE IS THEN TREATED WITH TAURINE IN A BASIC MEDIUM TO YIELD THE DESIRED 5B-TAUROCHOLENIC ACID SALT OR 5B-TAUROCHOLADIENIC ACID SALT; OR (2) BY THE REACTION OF THE ACID HALIDE OF CHOLENIC ACID WITH EITHER TAURINE OR WITH A SUITABLE TAURINE SALT IN THE PRESENCE OF A BASE. THE PRODUCTS ARE HYPOCHOLESTEROLEMICS AND HYPOLIPEMICS WHICH HAVE UTILITY IN THE TREATMENT OF CONDITIONS ASSOCIATED WITH BLOOD LIPID DEPOSITION.
Inventors
- 👤 Arthur A Patchett
- 👤 John Hannah
Bibliographic Details
Claims Analysis
Total Claims: 0References Cited (Backward Citations)
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