US3867329A
Expired / Lapsed
US
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Composition for a hydrogel dilator article of manufacture and method for making same
Assignee: Polysciences Inc
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Filing: 1972-08-25
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Granted: 1975-02-18
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Expires: 1992-08-25
Abstract
Abstract Composition, article of manufacture, and a method for forming a hydrogel dilation device for use internal the human body. An aqueous monomer solution, appropriate cross-linking agents, and catalysts are inserted into a mold tube having a predetermined internal contour shape. An inert gas is forced through the mixture contained in the mold tube. The tube is sealed by inserting plugs at opposing open tube ends. The mixture is then polymerized by keeping the tube in a controlled temperature environment for a predetermined length of time. A resulting moisture containing hydrogen rod is extruded from the mold tube. Water soluble impurities are removed from the hydrogel rod through dialysis in distilled water. The hydrogel rod is then dried in a stream of air until a predetermined percentage of the moisture is removed from the hydrogel rod. The hydrogel rod is then placed in a vacuum environment and heated for a predetermined length of time at a particular temperature until substantially all of the moisture is removed. An absorbant material may be inserted into the mold tube before polymerization. The absorbant material extends external to the hydrogel rod after formation and aids in transmitting body fluids internal to the dilation rod.
Inventors
- 👤 Benjamin D Halpern
- 👤 Murali Krishna Akkapeddi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 18:36
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0034; A61M; A61M29/00; A61M31/00
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
115 words
A HYDROGEL COMPOSITION COMPRISING AN INTIMATE MIXTURE ON A WEIGHT BASIS OF: (A) ABOUT 5.0 TO 30.0% OF GLYCERYL MONOMETHACRYLATE IN AQUEOUS SOLUTION, SAID WEIGHT PERCENTAGE OF SAID GLYCERYL MONOMETHACRYLATE BEING TAKEN WITH RESPECT TO SAID AQUEOUS SOLUTION; (B) ABOUT 0.2 TO 4.5% OF AT LEAST ONE DIACRYLATE CROSS-LINKER FROM THE GROUP CONSISTING OF DIETHYLENE GLYCOL DIACRYLATE, TETRAETHYLENE GLYCOL DIACRYLATE AND POLYETHYLENE GLYCOL DIACRYLATE, SAID WEIGHT PERCENTAGE OF SAID DIACRYLATE CROSS-LINKER BEING TAKEN WITH RESPECT TO SAID AQUEOUS SOLUTION; (C) ABOUT 0.2% OF AMMONIUM PERSULFATE; AND, (D) ABOUT 0.2% OF SODIUM BISULFITE, SAID WEIGHT PERCENTAGES OF SAID AMMONIUM PERSULFATE AND SAID SODIUM BISULFITE BEING TAKEN WITH RESPECT TO SAID GLYCERYL MONOMETHACRYLATE IN SAID AQUEOUS SOLUTION.
Claim 2
Dependent Claim
115 words
A HYDROGEL COMPOSITION COMPRISING AN INTIMATE MIXTURE ON A WEIGHT BASIS OF: (A) ABOUT 5.0 TO 30.0% OF GLYCERYL MONOMETHACRYLATE IN AQUEOUS SOLUTION, SAID WEIGHT PERCENTAGE OF SAID GLYCERYL MONOMETHACRYLATE BEING TAKEN WITH RESPECT TO SAID AQUEOUS SOLUTION; (B) ABOUT 0.2 TO 4.5% OF AT LEAST ONE DIACRYLATE CROSS-LINKER FROM THE GROUP CONSISTING OF DIETHYLENE GLYCOL DIACRYLATE, TETRAETHYLENE GLYCOL DIACRYLATE AND POLYETHYLENE GLYCOL DIACRYLATE, SAID WEIGHT PERCENTAGE OF SAID DIACRYLATE CROSS-LINKER BEING TAKEN WITH RESPECT TO SAID AQUEOUS SOLUTION; (C) ABOUT 0.2% OF AMMONIUM PERSULFATE; AND, (D) ABOUT 0.2% OF SODIUM BISULFITE, SAID WEIGHT PERCENTAGES OF SAID AMMONIUM PERSULFATE AND SAID SODIUM BISULFITE BEING TAKEN WITH RESPECT TO SAID GLYCERYL MONOMETHACRYLATE IN SAID AQUEOUS SOLUTION.
Claim 3
Dependent Claim
15 words
The hydrogel composition as recited in claim 1 wherein composition (B) is diethylene glycol diacrylate.
Claim 4
Dependent Claim
24 words
The hydrogel composition as recited in claim 2 wherein composition (A) includes an approximate glyceryl monomethacrylate weight percentage approximating 10.0% of said aqueous solution.
Claim 5
Dependent Claim
24 words
The hydrogel composition as reciTed in claim 2 wherein composition (A) includes an approximate glyceryl monomethacrylate weight percentage approximating 20.0% of said aqueous solution.
Claim 6
Dependent Claim
15 words
The hydrogel composition as recited in claim 1 wherein composition (B) is tetraethylene glycol diacrylate.
Claim 7
Dependent Claim
24 words
The hydrogel composition as recited in claim 5 wherein composition (A) includes an approximate glyceryl monomethacrylate weight percentage approximating 10.0% of said aqueous solution.
Claim 8
Dependent Claim
24 words
The hydrogel composition as recited in claim 5 wherein composition (A) includes an approximate glyceryl monomethacrylate weight percentage approximating 20.0% of said aqueous solution.
Claim 9
Dependent Claim
15 words
The hydrogel composition as recited in claim 1 wherein composition (B) is polyethylene glycol diacrylate.
Claim 10
Dependent Claim
24 words
The hydrogel composition as recited in claim 8 wherein composition (A) includes an approximate glyceryl monomethacrylate weight percentage approximating 10.0% of said aqueous solution.
Claim 11
Dependent Claim
24 words
The hydrogel composition as recited in claim 8 wherein composition (A) includes an approximate glyceryl monomethacrylate weight percentage approximating 20.0% of said aqueous solution.
Claim 12
Dependent Claim
91 words
A hydrogel composition comprising an intimate mixture on a weight basis of: (A) about 5.0 to 30.0% of a monomer from the group consisting of polyethylene glycol 4000 dimethacrylate and polyethylene glycol 4000 diacrylate in aqueous solution, said weight percentage of said polyethylene glycol 4000 diacrylate being taken with respect to said aqueous solution; (B) about 0.2% of ammonium persulfate; and (C) about 0.2% of sodium bisulfite, said weight percentages of said ammonium persulfate and said sodium bisulfite being with respect to said polyethylene glycol 4000 diacrylate in said aqueous solution.
Claim 13
Dependent Claim
91 words
A hydrogel composition comprising an intimate mixture on a weight basis of: (A) about 5.0 to 30.0% of a monomer from the group consisting of polyethylene glycol 4000 dimethacrylate and polyethylene glycol 4000 diacrylate in aqueous solution, said weight percentage of said polyethylene glycol 4000 diacrylate being taken with respect to said aqueous solution; (B) about 0.2% of ammonium persulfate; and (C) about 0.2% of sodium bisulfite, said weight percentages of said ammonium persulfate and said sodium bisulfite being with respect to said polyethylene glycol 4000 diacrylate in said aqueous solution.
Claim 14
Dependent Claim
26 words
The hydrogel composition as recited in claim 11 wherein composition (A) includes an approximate polyethylene glycol 4000 diacrylate weight percentage approximating 5.0% of said aqueous solution.
Claim 15
Dependent Claim
26 words
The hydrogel composition as recited in claim 11 wherein composition (A) includes an approximate polyethylene glycol 4000 diacrylate weight percentage approximating 30.0% of said aqueous solution.
Claim 16
Dependent Claim
123 words
A hydrogel composition comprising an intimate mixture on a weight basis of: (A) about 1.5 to 10.0% of a monomer in aqueous solution from the group consisting of polyethylene glycol 4000 diacrylate polyethylene glycol 4000 dimethacrylate, polyethylene glycol 6000 diacrylate, and polyethylene glycol 6000 dimethacrylate said weight percentage of said monomer being with respect to said aqueous solution; (B) about 1.5 to 4.0% of a comonomer in aqueous solution of acrylamide, said weight percentage of said comonomer being with respect to said aqueous solution; (c) about 0.2% of ammonium persulfate; and, (D) about 0.2% of sodium bisulfite, said weight percentages of said ammonium persulfate and said sodium bisulfite being taken with respect to said combined weight percentage of said monomer and said comonomer.
Claim 17
Dependent Claim
123 words
A hydrogel composition comprising an intimate mixture on a weight basis of: (A) about 1.5 to 10.0% of a monomer in aqueous solution from the group consisting of polyethylene glycol 4000 diacrylate polyethylene glycol 4000 dimethacrylate, polyethylene glycol 6000 diacrylate, and polyethylene glycol 6000 dimethacrylate said weight percentage of said monomer being with respect to said aqueous solution; (B) about 1.5 to 4.0% of a comonomer in aqueous solution of acrylamide, said weight percentage of said comonomer being with respect to said aqueous solution; (c) about 0.2% of ammonium persulfate; and, (D) about 0.2% of sodium bisulfite, said weight percentages of said ammonium persulfate and said sodium bisulfite being taken with respect to said combined weight percentage of said monomer and said comonomer.
Claim 18
Dependent Claim
16 words
The hydrogel composition as recited in claim 14 wherein composition (A) is polyethylene glycol 4000 diacrylate.
Claim 19
Dependent Claim
17 words
The hydrogel composition as recited in claim 15 wherein composition (B) is acrylamide in said aqueous solution.
Claim 20
Dependent Claim
24 words
The hydrogel composition as recited in claim 16 wherein said weight of polyethylene glycol 4000 diacrylate approximates 4.0% by weight of said aqueous solution.
Claim 21
Dependent Claim
21 words
The hydrogel composition as recited in claim 17 wherein said weight of acrylamide approximates 4.0% by weight of said aqueous solution.
Claim 22
Dependent Claim
24 words
The hydrogel composition as recited in claim 16 wherein said weight of polyethylene glycol 4000 diacrylate approximates 1.5% by weight of said aqueous solution.
Claim 23
Dependent Claim
21 words
The hydrogel composition as recited in claim 19 wherein said weight of acrylamide approximates 1.5% by weight of said aqueous solution.
Claim 24
Dependent Claim
20 words
The hydrogel composition as recited in claim 14 wherein composition (A) is polyethylene glycol 6000 diacrylate in said aqueous solution.
Claim 25
Dependent Claim
17 words
The hydrogel composition as recited in claim 21 wherein composition (B) is acrylamide in said aqueous solution.
Claim 26
Dependent Claim
25 words
The hydrogel composition as recited in claim 22 wherein said weight of said polyethylene glycol 6000 diacrylate approximates 1.75% by weight of said aqueous solution.
Claim 27
Dependent Claim
22 words
The hydrogel composition as recited in claim 23 wherein said weight of said acrylamide approximates 1.75% by weight of said aqueous solution.
Claim 28
Dependent Claim
25 words
The hydrogel composition as recited in claim 22 wherein said weight of said polyethylene glycol 6000 diacrylate approximates 1.5% by weight of said aqueous solution.
Claim 29
Dependent Claim
22 words
The hydrogel composition as recited in claim 25 wherein said weight of said acrylamide approximates 1.5% by weight of said acqueous solution.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-02-17 | 1978-08-19 | 1979-02-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-02-17 | 1982-08-19 | 1983-02-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-02-17 | 1986-08-19 | 1987-02-18 | $7700.00 | Window Closed / Lapsed |