Patent US3864398A successfully refreshed from Google Patents.
US3864398A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for the preparation of acylamino alkanol derivatives
Assignee: Aska Pharmaceutical Co Ltd
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Filing: 1972-05-01
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Granted: 1975-02-04
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Expires: 1992-05-01
Abstract
Abstract A novel process for the production of 1-(acylamino-aryloxy)-3amino-propanol derivative having an excellent Beta -adrenergic blocking effect. The process comprises basically reacting a compound of the formula WHEREIN Z is a hydrogen atom or a protective group bonded to the oxygen atom by an aliphatic ether linkage, and R stands for an alkyl or aralkyl group, with a compound of the formula WHEREIN Ar stands for a substituted or unsubstituted benzene or naphthalene ring, Ac indicates an organic acid residue, and Y represents a hydrogen atom, a monovalent hydrocarbon radical having up to 12 carbon atoms or an organic acid residue, or Y may be bonded to the group Ac to form a diacyl group.
Inventors
- 👤 Yasushi Suzuki
- 👤 Kunio Tsukamoto
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 09:23
CPC Classifications
C; C07; C07C; C07C233/00; C07C233/01; C07C233/16; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
12 words
A PROCESS FOR THE PREPARATION OF A 1-ARYLOXY-3-AMINOPROPANOL DERIVATIVE OF THE FORMULA
Claim 2
Dependent Claim
12 words
A PROCESS FOR THE PREPARATION OF A 1-ARYLOXY-3-AMINOPROPANOL DERIVATIVE OF THE FORMULA
Claim 3
Dependent Claim
19 words
The process of claim 1, wherein the reaction is carried out at a temperature ranging from 130* to 250*C.
Claim 4
Dependent Claim
17 words
The process of claim 1, wherein the reacTion is carried out in the absence of a catalyst.
Claim 5
Dependent Claim
16 words
The process of claim 1, wherein the reaction is carried out in an inert gas atmosphere.
Claim 6
Dependent Claim
24 words
The process of claim 1, wherein the compound of the formula (I) is reacted with a compound of formula (II) in the molten state.
Claim 7
Dependent Claim
19 words
The process of claim 1, wherein the reaction is carried out in the presence of an inert organic solvent.
Claim 8
Dependent Claim
21 words
The process of claim 6, wherein said inert organic solvent is selected from benzene, xylene, ether, benxyl alcohol, decalin or dioxane.
Claim 9
Dependent Claim
12 words
A process for the preparation of a 1-aryloxy-3-amino-propanol derivative of the formula
Claim 10
Dependent Claim
12 words
A process for the preparation of a 1-aryloxy-3-amino-propanol derivative of the formula
Claim 11
Dependent Claim
14 words
The process of claim 1, for the preparation of 1-(acylamino-aryloxy)-3-amino-2-propanol derivative of the formula
Claim 12
Dependent Claim
14 words
The process of claim 1, for the preparation of 1-(acylamino-aryloxy)-3-amino-2-propanol derivative of the formula
Claim 13
Dependent Claim
36 words
The process of claim 1, wherein the reaction is carried out in the presence of a solid caustic alkali in an amount of 1/100 to 1/10 mole per mole of the compound of the formula (II).
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-02-03 | 1978-08-05 | 1979-02-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-02-03 | 1982-08-05 | 1983-02-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-02-03 | 1986-08-05 | 1987-02-04 | $7700.00 | Window Closed / Lapsed |