5-(haloalkyl) picolinic acid and derivatives
Abstract
Abstract A 5-(haloalkyl)picolinic acid represented by the general formula, WHEREIN R1 represents an alkylene group having 3 to 6 carbon atoms and X represents a halogen atom, provided that the halogen atom is attached to the terminal carbon atom of the carbon chain or to the carbon atom at position 3'' in the case of a four-carbon chain, is a novel compound useful as a hypotensive agent. The said novel compound is obtained by reacting a 2-methyl-5(haloalkyl)-pyridine represented by the general formula, WHEREIN R1 and X have the same meaning as defined above, A. WITH A PEROXIDE TO FORM A 2-METHYL-5-(HALOALKYL)PYRIDINE-Noxide, converting the resulting N-oxide to a 2-hydroxymethyl-5(haloalkyl)pyridine ester by reaction with a carboxylic acid anhydride, hydrolyzing the resulting ester to a 2hydroxymethyl-5-(haloalkyl)-pyridine, and oxidizing the resulting compound with an oxidizing agent; or B. WITH BENZALDEHYDE IN THE PRESENCE OF A DEHYDRATING AGENT TO FORM A 2-STYRYL-5-(HALOALKYL)-PYRIDINE, AND OXIDIZING THE RESULTING STYRYL DERIVATIVE WITH AN OXIDIZING AGENT; OR C. WITH SELENIUM DIOXIDE TO EFFECT OXIDATION.
Inventors
- 👤 Hamao Umezawa
- 👤 Tomio Takeuchi
- 👤 Koichi Miyano
- 👤 Hiroaki Hamano
- 👤 Wataru Tanaka
Bibliographic Details
Claims Analysis
Total Claims: 2References Cited (Backward Citations)
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