US3862004A
Expired / Lapsed
US
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Method for production of cephalosporins
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1973-05-31
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Granted: 1975-01-21
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Expires: 1993-05-31
Abstract
Abstract WHEREIN R1, n an X have the aforementioned significances through the utilization of a microorganism having a cephalosporinsynthesizing activity. WHEREIN R has the aforementioned significance, or its reactive derivative and (2) a 7-aminocephem compound of the formula WHEREIN R stands for a six-membered cyclic hydrocarbon residue which is either substitued or unsubstituted and either saturated or unsaturated, or an unsaturated five-membered heterocyclic residue containing one hetero-atom in its ring; R1 stands for a hydrogen atom or -OR2 wherein R2 is an organic group; n is 1 or 2; and X is -OR3, -SOmR3, -NH2 or -CN, where R3 stands for an alkyl group of 1 to 3 carbon atoms or a phenyl group and m is 0, 1 or 2, are produced by condensation between (1) an Alpha substituted- Alpha -amino acid of the formula Cephalosporins of the formula
Inventors
- 👤 Takeshi Takahashi
- 👤 Yoshio Yamazaki
- 👤 Koichi Kato
- 👤 Masao Isono
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 00:21
CPC Classifications
C; C12; C12P; C12P35/00; C12P35/04; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/823; Y10S435/874
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
39 words
A method according to claim 1, wherein the Alpha -substituted acid or its reactive derivative and the 7-amino-cephem compound are contacted with a culture broth of the microorganism or with a cephalosporin-synthesizing-enzyme-containing processed matter obtained from the culture broth.
Claim 2
Dependent Claim
33 words
A method according to claim 2, wherein the contact is carried out at a temperature ranging from about 5* to about 50*C and at a pH ranging from about 4 to about 8.
Claim 3
Dependent Claim
54 words
A method according to claim 2, wherein the concentration of the 7-aminocephem compound in the aqueous medium is in a range from about 0.1 to about 10.0 % (weight/volume) and that of the Alpha -substituted- Alpha -amino acid or its reactive derivative is in a range from about 0.1 to about 20 %. (weight/volume).
Claim 4
Dependent Claim
26 words
A method according to claim 1, wherein X is -OR3, wherein R3 stands for an alkyl of 1 to 3 carbon atoms or a phenyl group.
Claim 5
Dependent Claim
33 words
A method according to claim 1, wherein X is -SOmR3 wherein R3 stands for an alkyl of 1 to 3 carbon atoms or a phenyl group and m is 0, 1 or 2.
Claim 6
Dependent Claim
12 words
A method according to claim 1, wherein X stands for amino group.
Claim 7
Dependent Claim
12 words
A method according to claim 1, wherein X stands for cyano group.
Claim 8
Dependent Claim
34 words
A method according to claim 1, wherein the reactive derivative of the Alpha -substituted- Alpha -amino acid is an alkyl ester, an aralkyl ester, an aryl ester or an alkylthio ester of the same.
Claim 9
Dependent Claim
20 words
A method according to claim 1, wherein the microorganism belongs to a genus Mycoplana, Protaminobacter, Acetobacter, Gluconobacter, Xanthomonas or Pseudomonas.
Claim 10
Dependent Claim
69 words
A method according to claim 1, wherein the microorganism is Acetobacter acetosus, Gluconobacter albidus, Acetobacter aurantium, Gluconobacter cerinus, Gluconobacter industrius, Gluconobacter dioxyacetonics, Gluconobacter gluconicus, Gluconobacter liquefaciens, Gluconobacter melanogenus, Gluconobacter oxydans, Acetobacter pasteurianus, Gluconobacter suboxydans, Acetobacter turbidans, Acetobacter xylinum, Xanthomonas campestris, Xanthomonas cucurbitae, Xanthomonas hyacinthi, Xanthomonas phaseoli, Xanthomonas physalidiacola, Xanthomonas citri, Xanthomonas pruni, Xanthomonas oryzae, Pseudomonas convexa, Pseudomonas maltophilla, Pseudomonas melanogenum, Pseudomonas vendrelli, Mycoplana dimorpha, Mycoplana bullata or Protaminobacter alboflavus.
References Cited (Backward Citations)
US3284451A
Cited
US3763000A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-01-20 | 1978-07-22 | 1979-01-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-01-20 | 1982-07-22 | 1983-01-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-01-20 | 1986-07-22 | 1987-01-21 | $7700.00 | Window Closed / Lapsed |