US3853466A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Diagnostic composition for the detection of urobilinogens
Assignee: Roche Diagnostics GmbH
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Filing: 1972-06-14
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Granted: 1974-12-10
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Expires: 1992-06-14
Abstract
Abstract Diagnostic agent for the detection of urobilinogens, optionally in the presence of bilirubin, in body fluids which agent comprises at least one stable benzene diazonium salt wherein the phenyl radical may be polysubstituted and contains in the o- or p-position at least one polyatomic electron donor group with at least one mesomeric electron pair, the sum of the Hammett sigma values for all the substituents not exceeding the value of +0.4.
Inventors
- 👤 W Rittersdorf
- 👤 P Rieckmann
- 👤 D Berger
- 👤 H Rey
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 17:31
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/72; Y; Y10; Y10S; Y10S436/00; Y10S436/903; Y10T; Y10T436/00; Y10T436/14; Y10T436/145555; Y10T436/146666
Claims Analysis
Total Claims: 35
Claim 1
Independent Claim
74 words
DIAGNOSTIC AGENT FOR THE DETECTION OF UROBILINOGEN IN BODY FLUID WHICH AGENT COMPRISES AN ACID AND AT LEAST ONE STABLE BENZENE DIAZONIUM SALT WHEREIN THE PHENYL RADICAL CONTAINS AT LEAST ONE POLYATOMIC ELECTRON DONOR GROUP SUBSTITUENT WITH AT LEAST ONE MESOMERIC ELECTRON PAIR, IN THE O- OR P-POSITION AND WHEREIN THE PHENYL RING MAY CONTAIN ADDITIONAL SUBSTITUENTS, THE SUM OF THE HAMMETT SIGMA VALUES FOR ALL THE SUBSTITUENTS NOT EXCEEDING THE VALUE OF +0.4.
Claim 2
Dependent Claim
74 words
DIAGNOSTIC AGENT FOR THE DETECTION OF UROBILINOGEN IN BODY FLUID WHICH AGENT COMPRISES AN ACID AND AT LEAST ONE STABLE BENZENE DIAZONIUM SALT WHEREIN THE PHENYL RADICAL CONTAINS AT LEAST ONE POLYATOMIC ELECTRON DONOR GROUP SUBSTITUENT WITH AT LEAST ONE MESOMERIC ELECTRON PAIR, IN THE O- OR P-POSITION AND WHEREIN THE PHENYL RING MAY CONTAIN ADDITIONAL SUBSTITUENTS, THE SUM OF THE HAMMETT SIGMA VALUES FOR ALL THE SUBSTITUENTS NOT EXCEEDING THE VALUE OF +0.4.
Claim 3
Dependent Claim
16 words
Diagnostic agent as claimed in claim 1 wherein said benzene diazonium salt is of the formula
Claim 4
Dependent Claim
17 words
Diagnostic agent as claimed in claim 2 wherein R1 is hydroxy or lower alkylthio or lower alkoxy.
Claim 5
Dependent Claim
26 words
Diagnostic agent as claimed in claim 2 wherein R2 is hydroxy or lower alkoxy, phenoxy, lower aralkoxy, lower alkylthio, phenylthio, lower phenylalkylamino, phenylamino or lower alkanoylamino.
Claim 6
Dependent Claim
20 words
Diagnostic agent as claimed in claim 2 wherein at least one of R1 and R2 is hydrogen, halogen or methyl.
Claim 7
Dependent Claim
29 words
Diagnostic agent as claimed in claim 2 wherein R3 and R4 are, inDividually, hydrogen, halogen, hydroxy, lower alkoxy, phenoxy, lower alkylthio, phenylthio, phenyl-lower alkylamino, lower alkyl, sulfo, or carboxyl.
Claim 8
Dependent Claim
23 words
Diagnostic agent as claimed in claim 2 wherein at least one of R2, R3 and R4 is substituted phenylamino or substituted lower alkanoylamino.
Claim 9
Dependent Claim
32 words
Diagnostic agent as claimed in claim 2 wherein X is a halide or the anion of an oxygen acid or the anion of a Lewis acid coordinatively saturated with a hydrogen halide.
Claim 10
Dependent Claim
21 words
Diagnostic agent as claimed in claim 8 wherein X is a chloride, sulfate, tetrafluoborate, tetrachlorozincate, hexachloroantimonate, arylsulfonate or carboxylic acid ion.
Claim 11
Dependent Claim
17 words
Diagnostic agent as claimed in claim 1 wherein said acid is a solid organic or inorganic acid.
Claim 12
Dependent Claim
23 words
Diagnostic agent as claimed in claim 10 wherein the acid is orthophosphoric acid, metaphosphoric acid, sulfosalicyclic acid, oxalic acid or an acid salt.
Claim 13
Dependent Claim
33 words
Diagnostic agent as claimed in claim 11 in the form of an absorbent carrier which has been impregnated with a solution of a solid acid and at least one of said diazonium salts.
Claim 14
Dependent Claim
12 words
Diagnostic agent as claimed in claim 12 additionally comprising a wetting agent.
Claim 15
Dependent Claim
16 words
Diagnostic agent as claimed in claim 12 additionally comprising a stabilizing agent for the diazonium salt.
Claim 16
Dependent Claim
26 words
Method for the detection of urobilinogen optionally together with bilirubin which method comprises contacting the test substance with a diagnostic agent as claimed in claim 1.
Claim 17
Dependent Claim
15 words
Diagnostic agent as claimed in claim 1 wherein said benzenediazonium salt is 4-methoxybenzene diazonium fluoborate.
Claim 18
Dependent Claim
15 words
Diagnostic agent as claimed in claim 1 wherein said benzenediazonium salt is 4-ethoxybenzene diazonium fluoborate.
Claim 19
Dependent Claim
15 words
Diagnostic agent as claimed in claim 1 wherein said benzenediazonium salt is 4-acetoamidobenzene diazonium fluoborate.
Claim 20
Dependent Claim
16 words
Diagnostic agent as claimed in claim 1 wherein said benzenediazonium salt is 3-chloro-4-methoxybenzene diazonium toluene sulfonate.
Claim 21
Dependent Claim
37 words
Diagnostic agent as claimed in claim 1 wherein said benzenediazonium salt is selected from the group consisting of: 2-methoxy-5-chlorobenzene diazonium tetrachlorozincate, 4-benzamido-2-methyl-5-methoxybenzene diazonium tetrachlorozincate, 4-benzamido-2,5-dimethoxybenzenediazonium tetrachlorozincate, 4-benzamido-2,5-diethoxybenzene diazonium tetrachlorozincate, 4-methoxyphenylaminobenzene diazonium chloride, and phenylaminobenzene diazonium hydrogen sulfate.
Claim 22
Dependent Claim
28 words
Diagnostic agent as claimed in claim 12 wherein said benzene-diazonium salt is at least one of 4-methoxybenzene diazonium fluoborate, 4-ethoxybenzene-diazonium-fluoborate, 4-acetoamidobenzene diazonium fluoborate or 3-chloro-4-methoxybenzene diazonium toluene sulfonate.
Claim 23
Dependent Claim
23 words
Method as claimed in claim 15 wherein said benzene-diazonium salt is 4-methoxybenzene diazonium fluoborate, 4-ethoxybenzene-diazonium-fluoborate, 4-acetoamidobenzene diazonium fluoborate or 3-chloro-4-methoxybenzene diazonium toluene sulfonate.
Claim 24
Dependent Claim
32 words
Diagnostic agent as claimed in claim 2 in the form of an absorbent carrier which has been impregnated with a solution of the acid and at least one of said benzene-diazonium salts.
Claim 25
Dependent Claim
32 words
Diagnostic agent as claimed in claim 3 in the form of an absorbent carrier which has been impregnated with a solution of the acid and at least one of said benzene-diazonium salts.
Claim 26
Dependent Claim
32 words
Diagnostic agent as claimed in claim 4 in the form of an absorbent carrier which has been impregnated with a solution of the acid and at least one of said benzene-diazonium salts.
Claim 27
Dependent Claim
32 words
Diagnostic agent as claimed in claim 5 in the form of an absorbent carrier which has been impregnated with a solution of the acid and at least one of said benzene-diazonium salts.
Claim 28
Dependent Claim
32 words
Diagnostic agent as claimed in claim 6 in the form of an absorbent carrier which has been impregnated with a solution of the acid and at least one of said benzene-diazonium salts.
Claim 29
Dependent Claim
32 words
Diagnostic agent as claimed in claim 7 in the form of an absorbent carrier which has been impregnated with a solution of the acid and at least one of said benzene-diazonium salts.
Claim 30
Dependent Claim
26 words
Method for the detection of urobilinogen optionally together with bilirubin which method comprises contacting the test substance with a diagnostic agent as claimed in claim 2.
Claim 31
Dependent Claim
26 words
Method for the detection of urobilinogen optionally together with bilirubin which method comprises contacting the test substance with a diagnostic agent as claimed in claim 3.
Claim 32
Dependent Claim
26 words
Method for the detection of urobilinogen optionally together with bilirubin which method comprises contacting the test substance with a diagnostic agent as claimed in claim 4.
Claim 33
Dependent Claim
26 words
Method for the detection of urobilinogen optionally together with bilirubin which method comprises contacting the test substance with a diagnostic agent as claimed in claim 5.
Claim 34
Dependent Claim
26 words
Method for the detection of urobilinogen optionally together with bilirubin which method comprises contacting the test substance with a diagnostic agent as claimed in claim 6.
Claim 35
Dependent Claim
26 words
Method for the detection of urobilinogen optionally together with bilirubin which method comprises contacting the test substance with a diagnostic agent as claimed in claim 7.
References Cited (Backward Citations)
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US3630680A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-12-09 | 1978-06-10 | 1978-12-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-12-09 | 1982-06-10 | 1982-12-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-12-09 | 1986-06-10 | 1986-12-10 | $7700.00 | Window Closed / Lapsed |