Abstract Pharmaceutical preparations of abortifacient PGE-type and PGFtype prostaglandins for injection directly into the uterine muscle of pregnant female mammals, including humans, and accomplishing a medical abortion. Methods of administration of the pharmaceutical preparations into the myometrial muscular tissue of the uterus during gestation to accomplish medical abortions. In another form of the invention, hot and/or cold gases may be injected into the interior of a rotational mold containing a molding material so as to react on the molding material and transfer heat thereto or receive heat therefrom so as to accelerate or effect the setting or solidifying of the material in situ against the wall of the mold or a previously deposited material. The alternate injection or spraying of molding materials and gases into the mold may be employed to form composite hollow or solid articles of predetermined compositions and physical characteristics.
Inventors
👤 J Lemelson
👤 K Kirton
👤 E Southern
Bibliographic Details
Application Number—
JurisdictionUS
Data Sourcegoogle_patents
Last Synchronized2026-10-23 16:29
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/557; A61K31/185
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
42 words
A METHOD OF ACCOMPLISHING A MEDICAL ABORTION IN A GESTATING MAMMAL CONSISTING ESSENTIALLY OF ADMINISTERING INTO THE MYOMETRIAL MUSCLE A STERILE PHARMACEUTICAL DISAGE FORM FOR MYOMETRIAL INJECTION CONSISTING ESSENTIALLY OF AN EFFECTIVE NON-TOXIC AMOUNT FOR ACCOMPLISHING SAID ABORTION OF AN ABORTIFACIENT PROSTAGLANDIN.
Claim 2
Independent Claim
42 words
A METHOD OF ACCOMPLISHING A MEDICAL ABORTION IN A GESTATING MAMMAL CONSISTING ESSENTIALLY OF ADMINISTERING INTO THE MYOMETRIAL MUSCLE A STERILE PHARMACEUTICAL DISAGE FORM FOR MYOMETRIAL INJECTION CONSISTING ESSENTIALLY OF AN EFFECTIVE NON-TOXIC AMOUNT FOR ACCOMPLISHING SAID ABORTION OF AN ABORTIFACIENT PROSTAGLANDIN.
Claim 3
Dependent Claim
20 words
A method according to claim 1 wherein said mammal is a human during the first third of the gestation period.
Claim 4
Dependent Claim
66 words
A method according to claim 2 wherein said prostaglandin is a member selected from the group consisting of the free acids, pharmaceutically acceptable salts, acylates wherein the acyl radical is that of a lower alkanoic acid having one to eight carbon atoms, inclusive, and carboxylate esters wherein the esterifying radical is alkyl of one to eight carbon atoms, inclusive, of a compound represented by the formula
Claim 5
Dependent Claim
15 words
A method according to claim 3 wherein said member is PGE2 or a salt thereof.
Claim 6
Dependent Claim
15 words
A method according to claim 3 wherein said member is PGF2 or a salt thereof.
Claim 7
Dependent Claim
25 words
A method according to claim 2 wherein the prostaglandin has a potency in the golden hamster pregnancy test at least equal to that of PGE2.
Claim 8
Dependent Claim
25 words
A method according to claim 2 wherein the prostaglandin has a potency in the golden hamster pregnancy test at least 10 times that of PGE2.
Claim 9
Dependent Claim
25 words
A method according to claim 2 wherein the prostaglandin has a potency in the golden hamster pregnancy test at least 100 times that of PGE2.