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US3852465A Expired / Lapsed US ⏱️ 0.0 years remaining

Abortion by myometrial administration of prostaglandins

Assignee: Pharmacia and Upjohn Co
•
Filing: 1973-08-16
•
Granted: 1974-12-03
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Expires: 1993-08-16
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Abstract

Abstract Pharmaceutical preparations of abortifacient PGE-type and PGFtype prostaglandins for injection directly into the uterine muscle of pregnant female mammals, including humans, and accomplishing a medical abortion. Methods of administration of the pharmaceutical preparations into the myometrial muscular tissue of the uterus during gestation to accomplish medical abortions. In another form of the invention, hot and/or cold gases may be injected into the interior of a rotational mold containing a molding material so as to react on the molding material and transfer heat thereto or receive heat therefrom so as to accelerate or effect the setting or solidifying of the material in situ against the wall of the mold or a previously deposited material. The alternate injection or spraying of molding materials and gases into the mold may be employed to form composite hollow or solid articles of predetermined compositions and physical characteristics.

Inventors

  • 👤 J Lemelson
  • 👤 K Kirton
  • 👤 E Southern

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 06:25
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/557; A61K31/185

Claims Analysis

Total Claims: 9
Claim 1
Independent Claim 42 words
A METHOD OF ACCOMPLISHING A MEDICAL ABORTION IN A GESTATING MAMMAL CONSISTING ESSENTIALLY OF ADMINISTERING INTO THE MYOMETRIAL MUSCLE A STERILE PHARMACEUTICAL DISAGE FORM FOR MYOMETRIAL INJECTION CONSISTING ESSENTIALLY OF AN EFFECTIVE NON-TOXIC AMOUNT FOR ACCOMPLISHING SAID ABORTION OF AN ABORTIFACIENT PROSTAGLANDIN.
Claim 2
Independent Claim 42 words
A METHOD OF ACCOMPLISHING A MEDICAL ABORTION IN A GESTATING MAMMAL CONSISTING ESSENTIALLY OF ADMINISTERING INTO THE MYOMETRIAL MUSCLE A STERILE PHARMACEUTICAL DISAGE FORM FOR MYOMETRIAL INJECTION CONSISTING ESSENTIALLY OF AN EFFECTIVE NON-TOXIC AMOUNT FOR ACCOMPLISHING SAID ABORTION OF AN ABORTIFACIENT PROSTAGLANDIN.
Claim 3
Dependent Claim 20 words
A method according to claim 1 wherein said mammal is a human during the first third of the gestation period.
Claim 4
Dependent Claim 66 words
A method according to claim 2 wherein said prostaglandin is a member selected from the group consisting of the free acids, pharmaceutically acceptable salts, acylates wherein the acyl radical is that of a lower alkanoic acid having one to eight carbon atoms, inclusive, and carboxylate esters wherein the esterifying radical is alkyl of one to eight carbon atoms, inclusive, of a compound represented by the formula
Claim 5
Dependent Claim 15 words
A method according to claim 3 wherein said member is PGE2 or a salt thereof.
Claim 6
Dependent Claim 15 words
A method according to claim 3 wherein said member is PGF2 or a salt thereof.
Claim 7
Dependent Claim 25 words
A method according to claim 2 wherein the prostaglandin has a potency in the golden hamster pregnancy test at least equal to that of PGE2.
Claim 8
Dependent Claim 25 words
A method according to claim 2 wherein the prostaglandin has a potency in the golden hamster pregnancy test at least 10 times that of PGE2.
Claim 9
Dependent Claim 25 words
A method according to claim 2 wherein the prostaglandin has a potency in the golden hamster pregnancy test at least 100 times that of PGE2.

References Cited (Backward Citations)

US2883233A Cited
US3021572A Cited
US3017670A Cited
US3002230A Cited
US3364292A Cited
US3095260A Cited
US3959820A Cited
US3974373A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1977-12-02 1978-06-03 1978-12-03 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1981-12-02 1982-06-03 1982-12-03 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1985-12-02 1986-06-03 1986-12-03 $7700.00 Window Closed / Lapsed

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