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US3852413A
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Labelled sulfated amylopectins and method of determining abnormal gastrointestinal mucosa
Assignee: GD Searle LLC
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Filing: 1972-07-03
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Granted: 1974-12-03
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Expires: 1992-07-03
Abstract
Abstract Described herein are dye and radionuclide labelled anionic polysaccharide compositions, useful as diagnostic aids in the qualitative and quantitative detection in mammals of abnormal mucosa, particularly of the gastrointestinal variety, a process for their preparation and a method for their use. Preferred embodiments are the compositions of: sodium amylosulfate combined with technetium-99m and sodium amylosulfate combined with methylene blue.
Inventors
- 👤 P Cammarata
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 17:59
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/001; A61K49/006; A61K49/04; A61K51/00; A61K51/02; A61K51/04; A61K51/06; A61K2123/00
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
44 words
A COMPOSITION COMPRISING AN ALKALI METAL SALT OF SULFATE POTATO STARCH AMYLOPECTIN, WHICH IS CHARACTERIZED BY A MOLECULAR WEIGHT OF AOUT 1-30X10**7 AND A SULFATE CONTENT OF ABOUT 1-1.8 SULFATE GROUPS PER GLUCOSE UNIT, CHEMICALLY COMBINED WITH A DIAGNOSTICALLY EFFECTIVE PHYSIOLOGICALLY SUITABLE LABELLING AGENT.
Claim 2
Dependent Claim
44 words
A COMPOSITION COMPRISING AN ALKALI METAL SALT OF SULFATE POTATO STARCH AMYLOPECTIN, WHICH IS CHARACTERIZED BY A MOLECULAR WEIGHT OF AOUT 1-30X10**7 AND A SULFATE CONTENT OF ABOUT 1-1.8 SULFATE GROUPS PER GLUCOSE UNIT, CHEMICALLY COMBINED WITH A DIAGNOSTICALLY EFFECTIVE PHYSIOLOGICALLY SUITABLE LABELLING AGENT.
Claim 3
Dependent Claim
35 words
The composition according to claim 1 wherein the alkali metal salt is the sodium salt possessing about 1.6 sulfate groups per glucose unit and characterized also by a molecular weight of about 6.3 X 107.
Claim 4
Dependent Claim
35 words
A composition according to claim 1 wherein the alkali metal salt is the sodium salt possessing about 1.8 sulfate groups per glucose unit and characterized also by a molecular weight of about 12.5 X 107.
Claim 5
Dependent Claim
18 words
The composition according to claim 1 wherein the diagnostically effective, physiologically suitable labelling agent is a thiazin dye.
Claim 6
Dependent Claim
17 words
The composition according to claim 1 wherein the diagnostically effective, physiologically suitable labelling agent is methylene blue.
Claim 7
Dependent Claim
50 words
A composition according to claim 1 comprising an alkali metal salt of sulfated potato starch amylopectin, which is characterized by a molecular weight of 1-30 X 107 and a sulfate content of 1-1.8 sulfate groups per glucose unit chemically combined with 0.01 to 5 percent by weight of methylene blue.
Claim 8
Dependent Claim
17 words
A composition according to claim 1 wherein the diagnostically effective, physiologically suitable labelling agent is a radionuclide.
Claim 9
Dependent Claim
16 words
A composition according to claim 1 wherein the diagnostically effective, physiologically suitable labelling agent is iodine-125.
Claim 10
Dependent Claim
16 words
The composition according to claim 1 wherein the diagnostically effective, physiologically suitable labelling agent is iodine-131.
Claim 11
Dependent Claim
16 words
The composition according to claim 1 wherein the diagnostically effective, physiologically suitable labelling agent is technetium-99m.
Claim 12
Dependent Claim
39 words
A composition comprising the sodium salt of sulfated potato starch amylopectin, which is characterized by a molecular weight of about 6.3 X 107 and a sulfate content of about 1.6 sulfate groups per glucose unit, chemically combined with technetium-99m.
Claim 13
Dependent Claim
39 words
A composition comprising the sodium salt of sulfated potato starch amylopectin, which is characterized by a molecular weight of about 6.3 X 107 and a sulfate content of about 1.6 sulfate groups per glucose unit, chemically combined with technetium-99m.
Claim 14
Independent Claim
82 words
A method of detecting abnormal gastrointestinal mucosa which comprises administering to a mammal a diagnostic dose of a composition comprising a sulfated polysaccharide, which differentially binds to the gastrointestinal mucosa, and which is characterized by a molecular weight of at least one million and a sulfate content of substantially 1-2 sulfate groups per monosaccharide unit, chemically combined with a diagnostically effective, physiologically suitable labelling agent, followed by examination of the mucosa in order to determine those portions containing bound labelled sulfated polysaccharide.
Claim 15
Independent Claim
82 words
A method of detecting abnormal gastrointestinal mucosa which comprises administering to a mammal a diagnostic dose of a composition comprising a sulfated polysaccharide, which differentially binds to the gastrointestinal mucosa, and which is characterized by a molecular weight of at least one million and a sulfate content of substantially 1-2 sulfate groups per monosaccharide unit, chemically combined with a diagnostically effective, physiologically suitable labelling agent, followed by examination of the mucosa in order to determine those portions containing bound labelled sulfated polysaccharide.
Claim 16
Dependent Claim
41 words
The method according to claim 12 wherein the polysaccharide is an alkali metal salt of sulfated potato starch amylopectin, said salt possessing about 1-1.8 sulfate groups per glucose unit and characterized also by a molecular weight of about 1-30 X 107.
Claim 17
Dependent Claim
37 words
The method according to claim 12 wherein the diagnostically effective, physiologically suitable labelling agent is methylene blue, which is visualized upon endoscopic examination of the mucosa in order to determine those portions containing bound labelled sulfated polysaccharide.
Claim 18
Dependent Claim
37 words
The method according to claim 12 wherein the diagnostically effective, physiologically suitable labelling agent is technetium-99m and the examination is conducted with a radiation imaging device in order to determine those portions containing bound labelled sulfated polysaccharide.
Claim 19
Independent Claim
79 words
The method of detecting abnormal gastrointestinal mucosa in mammals which comprises administering to the mammal a diagnostic dose of a composition comprising the sodium salt of a sulfated potato starch amylopectin possessing 1.8 sulfate groups per Glucose unit and characterized also by a molecular weight of 6.3 X 107, chemically combined with the diagnostically effective, physiologically suitable labelling agent, technetium-99m, followed by examination with a radiation imaging device in order to determine those portions containing bound labelled sulfated polysaccharide.
Claim 20
Independent Claim
79 words
The method of detecting abnormal gastrointestinal mucosa in mammals which comprises administering to the mammal a diagnostic dose of a composition comprising the sodium salt of a sulfated potato starch amylopectin possessing 1.8 sulfate groups per Glucose unit and characterized also by a molecular weight of 6.3 X 107, chemically combined with the diagnostically effective, physiologically suitable labelling agent, technetium-99m, followed by examination with a radiation imaging device in order to determine those portions containing bound labelled sulfated polysaccharide.
References Cited (Backward Citations)
US3637657A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-12-02 | 1978-06-03 | 1978-12-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-12-02 | 1982-06-03 | 1982-12-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-12-02 | 1986-06-03 | 1986-12-03 | $7700.00 | Window Closed / Lapsed |