US3852277A
Expired / Lapsed
US
⏱️ 0.0 years remaining
3-{8 ({60 -methoxy-4-substituted cinnamoyl)oxymethyl{9 -7-acylamidoceph-3-em-4-carboxylic acids
Assignee: Merck and Co Inc
•
Filing: 1972-08-02
•
Granted: 1974-12-03
•
Expires: 1992-08-02
Abstract
Abstract 3-(( Alpha -Methoxy-4-substituted cinnamoyl)oxymethyl)-7acylamidoceph-3-em-4-carboxylic acid esters are prepared by treating the 3-(( Alpha -methoxy-4-substituted cinnamoyl)oxymethyl)-7-aminoceph-3-em-4-carboxylic acid esters with an acylating agent. The compounds display an antibacterial action against gram-positive bacteria, for example, Bacillus subtilis and Staphlococcus aureaus, especially penicillinresistant strains, and are also useful against gram-negative bateria, for example, Escherichia coli and Salmonella schottmuelleri.
Inventors
- 👤 D Jacobus
- 👤 W Leanza
- 👤 B Christensen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 07:03
CPC Classifications
C; C07; C07D; C07D501/00; C07D501/14; C07D501/16; C07D501/20; C07D501/24; C07D501/26
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
5 words
A COMPOUND OF THE FORMULA
Claim 2
Dependent Claim
5 words
A COMPOUND OF THE FORMULA
Claim 3
Dependent Claim
5 words
A compound of the formula:
Claim 4
Dependent Claim
5 words
A compound of the formula:
Claim 5
Dependent Claim
40 words
A compound according to claim 2 wherein R3 is hydrogen, amino or carboxy; R4 is 3-amino-3-carboxypropyl, phenyl or a heterocyclic ring selected from the group consisting of furyl, thienyl, thiazolyl, isothiazolyl, oxadiazolyl, and thiazolyl and R2 is hydrogen or sulfo.
Claim 6
Dependent Claim
9 words
A compound according to claim 3 wherein the radical
Claim 7
Dependent Claim
13 words
A compound according to claim 4 named 3-(( Alpha -methoxy-4-hydroxycinnamoyl)oxymethyl)-7- Beta -(2-thienylacetamido)ceph-3-em-4-carboxylic acid.
Claim 8
Dependent Claim
13 words
A compound according to claim 4 named sodium 3-(( Alpha -methoxy-4-sulfoxycinnamoyl)oxymethyl)-7- Beta -(2-thienylacetamido)ceph-3-em-4-carboxylate.
Claim 9
Dependent Claim
13 words
A compound according to claim 4 named sodium 7- Beta -(D-5-amino-5-carboxyvaleramido)-3-(( Alpha -methoxy-4-hydroxycinnamoyl)oxymethyl)ceph-3-em-4-carboxylate.
Claim 10
Dependent Claim
13 words
A compound according to claim 4 named disodium 7- Beta -(D-5-amino-5-carboxyvaleramido)-3-(( Alpha -methoxy-4-sulfoxycinnamoyl)oxymethyl)ceph-3-em-4-carboxylate.
Claim 11
Dependent Claim
5 words
A compound of the formula:
Claim 12
Dependent Claim
5 words
A compound of the formula:
Claim 13
Dependent Claim
46 words
A compound according to claim 9 wherein R1 is a protecting group selected from trichloroethyl, tert-butyl, benzoylmethyl, p-methoxybenzyl, benzyl, benzhydryl, trityl, trimethylsilyl or methoxymethyl; R2 is hydrogen, trichloroethyl, tert-butyl, benzoylmethyl, p-methoxybenzyl, benzyl, benzhydryl, trityl, trimethylsilyl, methoxymethyl or tert-butyloxycarbonyl and R5 is tertiary butoxycarbonyl, trichloroethoxycarbonyl or triphenylmethyl.
References Cited (Backward Citations)
US3124576A
Cited
US3129224A
Cited
US3338897A
Cited
US3351596A
Cited
US3351597A
Cited
US3718644A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-12-02 | 1978-06-03 | 1978-12-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-12-02 | 1982-06-03 | 1982-12-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-12-02 | 1986-06-03 | 1986-12-03 | $7700.00 | Window Closed / Lapsed |