Psychopharmacologically active d-glu or d-his containing peptides

Abstract

Abstract 1. A PEPTIDE OF THE CORMULA: A-GLU(Q)-HIS-X IN WHICH ONE OF THE AMINO RADICALS GLU(Q) OR HIS IS PRESENT IN THE D-FORM; IN WHICH A IS SELECTED FROM THE GROUP CONSISTING OF H-L-MET, H-L-MET($O), H-L-MET($O2) DESAMINO-MEL, DESAMINO-MET($O), DESAMINO-MEL($O2), AND THE MOIETY; H2N-B-CO- IN WHICH B IS ALKYLENE HAVING 1-6 CARBON ATOMS; Q IS SELECTED FROM THE GROUP CONSISTING OF OH AND NH2; X IS SELECTED FROM THE GROUP CONSISTING OF HYDROXY; (N-PHENYLALKYL) AMINO OF THE FORMULA -NH-ALK-PHENYLENE-R1 IN WHICH ALK IS ALKYLENE WITH 1-6 CARBON ATOMS, AND R1 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND HYDROXY; AND -L-PHE-Y; Y IS SELECTED FROM THE GROUP CONSISTING OF HYDROXY, DESCARBOXYL-LYSYL, DESCARBOXY - ARGIINYL, -L-LYS-Z, -L-ARG-Z, -D-LYS-Z, AND -D-ARG-Z; Z IS SELECTED FROM THE GROUP CONSISTING OF HYDROXY, (N-B-INDOLYL-ETHYL) AMINO, -L-TRP-OH, -L-TRP-GLY-OH, -L-PHE-OH, -L-PHE-GLY-OH, AND (N-PHENYLALKYL) AMINO OF THE FORMULA -NH-ALK-PHENYLENE-R1 IN WHICH ALK IS ALKYLENE WITH 1-6 CARBON ATOMS, R1 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND HYDROXY; AND FUNCTIONAL DERIVATIVES OF SAID PEPTIDE SELECTED FROM THE GROUP CONSISTING OF PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS DERIVATIVES IN WHICH ONE OR MORE FREE AMINO GROUPS ARE SUBSTITUTED BY ACYL DERIVED FROM AN ALIPHATIC CARBOXYLIC ACID WITH 1-6 CARBON ATOMS, UNSUBSTITUTED AMIDES OR LOWER ALKYL (1-6C) SUBSTITUTED AMIDES OF THOSE PEPIDES HAVING A FREE CARBOXYL GROUPS, ESTERS DERIVED FROM ALIPHATIC OR PHENYLALIPHATIC ALCOHOLS WITH 1-18 CARBON ATOMS, AND METAL COMPLEXES THEREOF.

Inventors

• 👤 H Greven

Bibliographic Details