Patent US3850174A successfully refreshed from Google Patents.
US3850174A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Plasma separator assembly
Assignee: Becton Dickinson and Co
•
Filing: 1973-03-14
•
Granted: 1974-11-26
•
Expires: 1993-03-14
Abstract
Abstract An assembly adapted to receive blood for separation into a light liquid phase of serum or plasma and a heavy phase is disclosed. The assembly includes a self-sealing, pierceable, elastomeric stopper-piston member which is capable of acting as a slidable piston as well as a closure for holding a vacuum in an evacuated container for collecting blood. Means is provided which is capable of pushing the piston member downwardly in the container; the means having a pointed tubular member associated therewith which is capable of piercing the piston so as to provide a passage for conducting the separated light liquid phase from one side of the stopper-piston to the other side thereof.
Inventors
- 👤 W Ayres
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:35
CPC Classifications
B; B01; B01L; B01L3/00; B01L3/50; B01L3/502; B01L3/5021; A; A61; A61B; A61B5/00; A61B5/15; A61B5/150007; A61B5/150015; A61B5/15003; A61B5/150206; A61B5/150213; A61B5/150251; A61B5/150351; A61B5/150374; A61B5/150381; A61B5/150389; A61B5/150473; A61B5/150496; A61B5/150755; A61B5/153; A61B5/154; Y; Y10; Y10T; Y10T436/00; Y10T436/25; Y10T436/25375
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
343 words
An assembly for collecting blood and anti-coagulant treated blood and for separating said blood into its light liquid phase and its heavy, substantially cellular phase which comprises; a blood collection container having at least one open end; a stopper-piston slidably mounted in said open end made of a self-sealing, elastomeric, pierceable material which functions as a stopper to seal said open end of said blood collection container when emplaced therein and which functions as a piston when moving from its position at the open end of said container to a position within said container which is intermediate to the ends thereof; said stopper-piston having; i. a lower tubular body portion having sliding-sealing means positioned around the outer periphery thereof and integrally formed therewith, said tubular body portion with sealing means being of a dimension such that when inserted in said container, a sliding seal is made with the inner walls of said container; and ii. an upper solid body portion having integrally formed means on the outer periphery thereof for (a) engaging the rim of the open end of said container when the stopper-piston functions as a stopper and for (b) forming a seal with the inner walls of said container when the stopper-piston functions as a piston; and means for sliding said stopper-piston downwardly into said collection chamber when it contains blood separated into its light and heavy phases, so as to establish an impermeable barrier separating the lighT liquid phase from the heavy phase of blood which comprises a pusher having, A. a blunt end for pressing against the upper surface of said stopper-piston; and B. a tubular member mounted at said blunt end and being capable of piercing said stopper-piston to form a passage therethrough, said tubular member having open ends so that upon piercing said stopper-piston there is fluid communication via said member between the upper and lower surfaces of the stopper-piston and whereby an axial force exerted against said pusher will cause the light phase to be conducted through the tubular member, enabling the stopper-piston to move downwardly.
Claim 2
Dependent Claim
343 words
An assembly for collecting blood and anti-coagulant treated blood and for separating said blood into its light liquid phase and its heavy, substantially cellular phase which comprises; a blood collection container having at least one open end; a stopper-piston slidably mounted in said open end made of a self-sealing, elastomeric, pierceable material which functions as a stopper to seal said open end of said blood collection container when emplaced therein and which functions as a piston when moving from its position at the open end of said container to a position within said container which is intermediate to the ends thereof; said stopper-piston having; i. a lower tubular body portion having sliding-sealing means positioned around the outer periphery thereof and integrally formed therewith, said tubular body portion with sealing means being of a dimension such that when inserted in said container, a sliding seal is made with the inner walls of said container; and ii. an upper solid body portion having integrally formed means on the outer periphery thereof for (a) engaging the rim of the open end of said container when the stopper-piston functions as a stopper and for (b) forming a seal with the inner walls of said container when the stopper-piston functions as a piston; and means for sliding said stopper-piston downwardly into said collection chamber when it contains blood separated into its light and heavy phases, so as to establish an impermeable barrier separating the lighT liquid phase from the heavy phase of blood which comprises a pusher having, A. a blunt end for pressing against the upper surface of said stopper-piston; and B. a tubular member mounted at said blunt end and being capable of piercing said stopper-piston to form a passage therethrough, said tubular member having open ends so that upon piercing said stopper-piston there is fluid communication via said member between the upper and lower surfaces of the stopper-piston and whereby an axial force exerted against said pusher will cause the light phase to be conducted through the tubular member, enabling the stopper-piston to move downwardly.
Claim 3
Dependent Claim
47 words
The assembly of claim 1 wherein said stopper-piston includes a tubular body portion having a diameter less than the inner diameter of said blood collection container and a plurality of circumferentially spaced rings integrally formed around the outer periphery thereof; said spaced rings comprising the sliding-sealing means.
Claim 4
Dependent Claim
73 words
The assembly of claim 1 wherein said tubular body portion is formed having three spaced lobes so that when said stopper-piston is mounted in the open end of said blood collection container, said lobes will compress inwardly toward the axis of the stopper-piston to provide three supporting contact areas to maintain the stopper-piston in axial alignment when an axial force is exerted against the piston to move the piston downwardly into the container.
Claim 5
Dependent Claim
53 words
The assembly of claim 3 wherein said three lobes are separated 120* each lobe being separated by a venting channel the sides of which are defined by the end surfaces of the adjacent lobes, the base of said venting channel being inclined with respect to the longitudinal axis of said tubular body portion.
Claim 6
Dependent Claim
34 words
The assembly of claim 4 wherein the base of the venting channel is inclined 45*; the upper and outer edge portion of which terminates adjacent said sealing ring formed on said tubular body portion.
Claim 7
Dependent Claim
31 words
The assembly of claim 1 wherein a cap is removably mounted over the end of the blood collection container containing the stopper-piston so as to maintain the assembly in aseptic condition.
Claim 8
Dependent Claim
36 words
The assembly of claim 6 wherein the cap is made of elastomeric and pierceable material, said cap having a deformable skirt portion capable of forming a compressive fit over the open outer end of said container.
Claim 9
Dependent Claim
322 words
For collection, separation and storage of blood plasma and blood serum, an assembly comprising: A. an evacuated tubular container having one end open and the other end closed; B. a stopper-piston slidably mounted in said open end; said stopper-piston being adapted to both maintain a vacuum within said assembly prior to being filled with blood and being adapted to slide downwardly into the container upon application of axial pressure so as to establish an impermeable barrier substantially between the separated serum or plasma and cellular phases of blood; said stopper-piston comprising a self-sealing, elastomeric, pierceable material having (i) a lower tubular body portion having sliding-sealing means positioned around the periphery thereof and integrally formed therewith, said tubular body portion with sealing means being of a dimension such that when inserted in said container, a sliding seal is made with the inner walls of said container; and (ii) an upper solid body portion having integrally formed means on the outer periphery thereof for engaging the rim of the open end of said container so as to maintain a vacuum within said assembly prior to being filled with blood; and C. means for sliding said stopper-piston downwardly into said collection chamber when it contains blood separated into its light and heavy phases, so as to establish an impermeable barrier separating the light liquid phase from the heavy phase of blood which comprises a pusher having, i. a blunt end for pressing against the upper surface of said stopper-piston, and ii. a tubular member mounted at said blunt end and Being capable of piercing said stopper-piston to form a passage therethrough, said tubular member having open ends so that upon piercing said stopper-piston the tubular member provides fluid communication between the upper and lower sides of the stopper-piston and whereby an axial force exerted against said pusher will cause the light phase to be conducted through the tubular member, enabling the stopper-piston to move downwardly.
Claim 10
Dependent Claim
322 words
For collection, separation and storage of blood plasma and blood serum, an assembly comprising: A. an evacuated tubular container having one end open and the other end closed; B. a stopper-piston slidably mounted in said open end; said stopper-piston being adapted to both maintain a vacuum within said assembly prior to being filled with blood and being adapted to slide downwardly into the container upon application of axial pressure so as to establish an impermeable barrier substantially between the separated serum or plasma and cellular phases of blood; said stopper-piston comprising a self-sealing, elastomeric, pierceable material having (i) a lower tubular body portion having sliding-sealing means positioned around the periphery thereof and integrally formed therewith, said tubular body portion with sealing means being of a dimension such that when inserted in said container, a sliding seal is made with the inner walls of said container; and (ii) an upper solid body portion having integrally formed means on the outer periphery thereof for engaging the rim of the open end of said container so as to maintain a vacuum within said assembly prior to being filled with blood; and C. means for sliding said stopper-piston downwardly into said collection chamber when it contains blood separated into its light and heavy phases, so as to establish an impermeable barrier separating the light liquid phase from the heavy phase of blood which comprises a pusher having, i. a blunt end for pressing against the upper surface of said stopper-piston, and ii. a tubular member mounted at said blunt end and Being capable of piercing said stopper-piston to form a passage therethrough, said tubular member having open ends so that upon piercing said stopper-piston the tubular member provides fluid communication between the upper and lower sides of the stopper-piston and whereby an axial force exerted against said pusher will cause the light phase to be conducted through the tubular member, enabling the stopper-piston to move downwardly.
Claim 11
Dependent Claim
33 words
The assembly of claim 8 including a sealing cap member adapted to close said tubular container to contain the serum or plasma within the tube and between the stopper-piston and the cap member.
Claim 12
Dependent Claim
80 words
The assembly of claim 8 wherein said stopper-piston has at least one air channel for use during manufacture of the assembly whereby the stopper-piston may be partially inserted in the tubular container and the assembly be placed within a chamber, subsequently evacuated, said air channel enabling the air within the container to flow out, with the stopper-piston later being pushed farther into the container thereby sealing off the air channel and thereafter maintaining the vacuum until the assembly is used.
Claim 13
Dependent Claim
16 words
The assembly of claim 10 wherein said stopper-piston has three air channels located substantially 120* apart.
Claim 14
Dependent Claim
24 words
The assembly of claim 9 wherein said sealing cap member has a portion of its skirt with a smaller diameter than the skirt opening.
References Cited (Backward Citations)
US2372182A
Cited
US2649090A
Cited
US3376866A
Cited
US3378008A
Cited
US3508653A
Cited
US3661265A
Cited
US3753432A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-11-25 | 1978-05-27 | 1978-11-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-11-25 | 1982-05-27 | 1982-11-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-11-25 | 1986-05-27 | 1986-11-26 | $7700.00 | Window Closed / Lapsed |