Analogues of human thyrocalcitonin

Abstract

Abstract 1. PEPTIDES OF THE FORMULA I H-CYS-GLY-ASN-LEU-SER-THR-CYS-MET-LEU-GLY-THR-TYR-THR-GLNASP-PHE-ASN-LYS-PHE-HIS-THR-PHE-PRO-GLN-THR-ALA-ILEGLY-VAL-GLY-ALA-PRO-NH2, WHERE THE CYS RESIDUES ARE JOINED, IN WHICH THE AMINOACID IN POSITION 8 IS REPLACED BY VALINE, NORVALINE, LEUCINE, ISOLEUCINE, NORLEUCINE OR A-AMINOBYTYRIC ACID, AND THOSE WHICH CONTAIN GLYCINE IN POSITION 12 AND THOSE WHICH CONTAIN METHIONINE IN POSITION 8 AND GLYCINE IN POSITIONS 12 AND 18, OR AT LEAST IN POSITION 12, THEIR ANTIPARALLEL DIMER AND NA-ACYL DERIVATIVES WHEREIN ACRYL IS LOWER MONOBASIC OR DIBASIC ALKANOYL, LOWER ALKYLOXYCARBONYL, BENZYLOXYCARBONYL, L-PYROGLUTAMYL, CARBAMOYL, N-LOWER ALKYLCARBAMOYL, N-PHENYLCARBAMOYL, OR N-PHENYLTHIOCARBAMOYL, OR DESAMINO1-DERIVATIVES OF THE MONOMERIC OR DIMERIC PEPTIDES, AS WELL AS THERAPEUTICALLY ACCEPTABLE ACID ADDITIONS SALTS AND COMPLEXES WITH A MEMBER SELECTED FROM THE GROUP CONSISTING OF ZINC PHOSPHATE, ZINC PYROPHOSPHATE, ZINC HYDROXIDE, GELATINE, POLYPHLORETIN PHOSPHATE AND POLYGLUTAMIC ACID, OF THE SAID MONOMERIC OR DIMERIC PEPTIDES WITH THE PROVISO THAT ALL AMINOACID RESIDURS OTHER THAN GLYCINE ARE TO THE L-CONFIGURATION.

Inventors

• 👤 W Rittel
• 👤 H Greven
• 👤 B Riniker
• 👤 P Sieber
• 👤 M Brugger
• 👤 B Kamber

Bibliographic Details