Patent US3847745A successfully refreshed from Google Patents.
US3847745A
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Preparation of water-insoluble biologically active materials
Assignee: Exploaterings TBF AB
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Filing: 1973-03-20
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Granted: 1974-11-12
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Expires: 1993-03-20
Abstract
Abstract Biologically active materials such as enzymes and hormones are coupled by an isonitrile group-containing compound to insoluble organic, hydrophilic polymeric carriers.
Inventors
- 👤 R Axen
- 👤 P Vretblad
- 👤 J Porath
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 13:51
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/395; A61K39/44; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/58; A61K47/61; C; C08; C08F; C08F8/00; C12; C12N; C12N11/00; C12N11/02; C12N11/08; C12N11/082; C12N11/087; C12N11/098; C12N11/10; C12Q; C12Q1/00; C12Q1/001; C12Q1/002; C12Q1/003; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54353; G01N33/544; G01N33/548; Y; Y10; Y10S; Y10S530/00; Y10S530/81; Y10S530/812; Y10S530/813; Y10S530/814; Y10S530/815; Y10S530/816
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
170 words
A METHOD OF PREPARING A WATER-INSOLUBLE BIOLOGICALLY ACTIVE POLYMERIC MATERIAL WHICH COMPRISES ADMIXING IN AN AQUEOUS MEDIUM AT LEAST THREE SUBSTANCES OF WHICH AT LEAST ONE IS AN INSOLUBLE ORGANIC, HYDROPHILIC POLYMER AND AT LEAST ONE OTHER IS A BIOLOGICALLY ACTIVE WATER-SOLUBLE ORGANIC SUBSTANCE AND A THIRD IS AN ISONITRILE GROUP-CONTAINING COMPOUND, SAID BIOLOGICALLY ACTIVE WATER-SOLUBLE ORGANIC SUBSTANCE BEING SELECTED FROM THE GROUP CONSISTING OF ENZYMES AND HORMONES, SAID POLYMER BEING SELECTED FROM THE GROUP CONSISTING OF CROSS-LINKED DEXTRAN, AGAROSE, POLYACRYLAMIDE, POLYMETHYLMETHYACRYLATE, AND DERIVATES THEREOF, AT LEAST ONE OF SAID AT LEAST THREE SUBSTANCES CONTAINING AN ANION, AT LEAST ONE OF SAID AT LEAST THREE SUBSTNCES CONTAININF A PRIMARY OR SECONDARY AMINO GROUP, AT LEAST ONE OF SAID AT LEAST THREE SUBSTANCES OTHER THAN SAID WATER-SOLUBLE ORGANIC SUBSTANCE CONTAINING ADEHYDE OR KETONE, REACTING SAID AT LEAST THREE SUBSTANCES TO FROM A SAID WATER-INSOLUBLE POLYMERIC MATERIAL WHEREIN SAID WATER-SOLUBLE ORGANIC SUBSTANCE IS COUPLED TO SAID POLYMER BY SAID ISONIRILE GROUP-CONTAINING COMPOUND AND SEPARATING SAID WATER-INSOLUBLE POLYMERIC MATERIAL FROM THE AQUEOUS MEDIUM.
Claim 2
Independent Claim
170 words
A METHOD OF PREPARING A WATER-INSOLUBLE BIOLOGICALLY ACTIVE POLYMERIC MATERIAL WHICH COMPRISES ADMIXING IN AN AQUEOUS MEDIUM AT LEAST THREE SUBSTANCES OF WHICH AT LEAST ONE IS AN INSOLUBLE ORGANIC, HYDROPHILIC POLYMER AND AT LEAST ONE OTHER IS A BIOLOGICALLY ACTIVE WATER-SOLUBLE ORGANIC SUBSTANCE AND A THIRD IS AN ISONITRILE GROUP-CONTAINING COMPOUND, SAID BIOLOGICALLY ACTIVE WATER-SOLUBLE ORGANIC SUBSTANCE BEING SELECTED FROM THE GROUP CONSISTING OF ENZYMES AND HORMONES, SAID POLYMER BEING SELECTED FROM THE GROUP CONSISTING OF CROSS-LINKED DEXTRAN, AGAROSE, POLYACRYLAMIDE, POLYMETHYLMETHYACRYLATE, AND DERIVATES THEREOF, AT LEAST ONE OF SAID AT LEAST THREE SUBSTANCES CONTAINING AN ANION, AT LEAST ONE OF SAID AT LEAST THREE SUBSTNCES CONTAININF A PRIMARY OR SECONDARY AMINO GROUP, AT LEAST ONE OF SAID AT LEAST THREE SUBSTANCES OTHER THAN SAID WATER-SOLUBLE ORGANIC SUBSTANCE CONTAINING ADEHYDE OR KETONE, REACTING SAID AT LEAST THREE SUBSTANCES TO FROM A SAID WATER-INSOLUBLE POLYMERIC MATERIAL WHEREIN SAID WATER-SOLUBLE ORGANIC SUBSTANCE IS COUPLED TO SAID POLYMER BY SAID ISONIRILE GROUP-CONTAINING COMPOUND AND SEPARATING SAID WATER-INSOLUBLE POLYMERIC MATERIAL FROM THE AQUEOUS MEDIUM.
Claim 3
Dependent Claim
14 words
A method accorDing to claim 1 in which said anion is a carboxylate anion.
Claim 4
Dependent Claim
15 words
A method according to claim 1 in which said isonitrile group-containing compound is dimethyl-aminopropyl isonitrile.
References Cited (Backward Citations)
US3645852A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-11-11 | 1978-05-13 | 1978-11-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-11-11 | 1982-05-13 | 1982-11-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-11-11 | 1986-05-13 | 1986-11-12 | $7700.00 | Window Closed / Lapsed |