Abstract A process for the production of 1-aminoalkane-1,1-diphosphonates of the formula WHEREIN R1 is a member selected from the group consisting of hydrogen, lower alkyl and phenyl, R2 and R3 are members selected from the group consisting of hydrogen, alkyl having one to 22 carbon atoms, cycloalkyl having five to six carbon atoms, phenyl, alkylphenyl having seven to 18 carbon atoms, phenylalkyl having seven to 18 carbon atoms and together with the nitrogen atom, piperidino, pyrrolidino and morpholino, and X is a member selected from the group consisting of hydrogen, alkali metal, ammonium, pyridinium, guanidinium and mono-, di-, and tri-loweralkanol-ammonium with the proviso that at least one of R1, R2 and R3 is other than hydrogen, which consists essentially in reacting a phosphorus trihalide selected from the group consisting of phosphosus trichloride and phosphorus tribromide with a monocarboxylic acid amide of the formula D R A W I N G
A PROCESS FOR THE PRODUCTION OF A COMPOUND OF THE FORMULA
Claim 2
Dependent Claim
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A PROCESS FOR THE PRODUCTION OF A COMPOUND OF THE FORMULA
Claim 3
Dependent Claim
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The process of claim 1 wherein the molar ratio of said phosphorus trihalide to said monocarboxylic acid amide is from 3: 1 to 1:1.
Claim 4
Dependent Claim
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The process of claim 1 wherein the molar ratio of said phosphorus trihalide to said monocarboxylic acid amide is substantially 1 to 1.
Claim 5
Dependent Claim
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The process of claim 1 wherein said hydrolysis is conducted with water and said compound is recovered where X is hydrogen.
Claim 6
Dependent Claim
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The process of claim 1 wherein said hydrolysis is conducted with an aqueous solution of an alkaline salt selected from the group consisting of alkali metal carbonates and alkali metal hydroxides and said compound is recovered where X is alkali metal.
Claim 7
Dependent Claim
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The process of claim 1 wherein said monocarboxylic acid amide has the formula
Claim 8
Dependent Claim
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The process of claim 1 wherein said monocarboxylic acid amide has the formula
Claim 9
Dependent Claim
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The process of claim 1 wherein said monocarboxylic acid amide has the formula
Claim 10
Dependent Claim
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The process of claim 1 wherein said phosphorus trihalide is phosphorus trichloride.
Claim 11
Dependent Claim
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The process of claim 1 wherein the reaction of said phosphorus trihalide with said monocarboxylic acid amide is carried out with addition of phosphorous acid.
Claim 12
Dependent Claim
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The process of claim 10, in which the ratio of phosphorus trihalide to phosphorous acid is substantially 1:1.
Claim 13
Dependent Claim
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A process for the production of a compound of the formula
Claim 14
Dependent Claim
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A process for the production of a compound of the formula