Process for the preparation of 1-aminoalkane-1,-diphosphonic acids and their salts
Abstract
Abstract A process for the production of 1-aminoalkane-1,1-diphosphonates of the formula WHEREIN R1 is a member selected from the group consisting of hydrogen, lower alkyl and phenyl, R2 and R3 are members selected from the group consisting of hydrogen, alkyl having one to 22 carbon atoms, cycloalkyl having five to six carbon atoms, phenyl, alkylphenyl having seven to 18 carbon atoms, phenylalkyl having seven to 18 carbon atoms and together with the nitrogen atom, piperidino, pyrrolidino and morpholino, and X is a member selected from the group consisting of hydrogen, alkali metal, ammonium, pyridinium, guanidinium and mono-, di-, and tri-loweralkanol-ammonium with the proviso that at least one of R1, R2 and R3 is other than hydrogen, which consists essentially in reacting a phosphorus trihalide selected from the group consisting of phosphosus trichloride and phosphorus tribromide with a monocarboxylic acid amide of the formula D R A W I N G
Inventors
- 👤 K Wollmann
- 👤 W Ploger
- 👤 K Worms
Bibliographic Details
Claims Analysis
Total Claims: 14References Cited (Backward Citations)
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