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US3843628A
Expired / Lapsed
US
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Cardiotonic glycosides
Assignee: Shionogi and Co Ltd
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Filing: 1971-05-11
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Granted: 1974-10-22
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Expires: 1991-05-11
Abstract
Abstract Novel 17 Beta -(3-furyl)-5 Beta ,14 Beta -and rostane-3 Beta , 14,16 Beta -triol 3-tridigitoxoside, its acylates and acetals having stronger digitalis-like cardiotonic activity and process for preparation thereof by reaction of gitoxin, its acylates or acetals with an active reducing agent.
Inventors
- 👤 H Minato
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 13:18
CPC Classifications
C; C07; C07J; C07J17/00; B; B60; B60C; B60C11/00; B60C11/14; B60C11/16; C07J73/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
31 words
17B-(3-FURYL)-5B,14B-ANDROSTANE-3B,14,16B-TRIOL-3TRIDIGITOXOSIDE AND ITS 3''",4"''-CYCLIC CARBONATE, PHARMACEUTICALLY ACCEPTABLE CARBOXYLIC ACYLATES CONTAINING 1 TO 18 CARBON ATOMS AND PHARMACEUTICALLY ACCEPTABLE 3''''''4''''''-ACETALS IN WHICH THE ACETAL CARBONYL MOIETY CONTAINS 1 TO 7 CARBON ATOMS.
Claim 2
Dependent Claim
31 words
17B-(3-FURYL)-5B,14B-ANDROSTANE-3B,14,16B-TRIOL-3TRIDIGITOXOSIDE AND ITS 3''",4"''-CYCLIC CARBONATE, PHARMACEUTICALLY ACCEPTABLE CARBOXYLIC ACYLATES CONTAINING 1 TO 18 CARBON ATOMS AND PHARMACEUTICALLY ACCEPTABLE 3''''''4''''''-ACETALS IN WHICH THE ACETAL CARBONYL MOIETY CONTAINS 1 TO 7 CARBON ATOMS.
Claim 3
Dependent Claim
19 words
A compound according to claim 1, that is 17 Beta -(3-furyl)-5 Beta ,14 Beta -androstane-3 Beta ,14,16 Beta -triol-3-tridigitoxoside.
Claim 4
Dependent Claim
27 words
A compound according to claim 1 wherein the carboxylic acylates are selected from the group consisting of alkanoates, succinates, acrylates, cyclopentanepropionates, aspartates, phenoxyacetates, haloacetates, benzoates and furoates.
Claim 5
Dependent Claim
21 words
A compound according to claim 3, that is 17 Beta -(3-furyl)-5 Beta ,14 Beta -androstane-3 Beta ,14,16 Beta -triol-3tridigitoxoside 16,3'',3'''', 3'''''',4''''''-pentaacetate.
Claim 6
Dependent Claim
20 words
A compound according to claim 1, that is 17 Beta -(3-furyl)-5 Beta ,14 Beta -androstane-3 Beta ,14,16 Beta -triol-3-tridigitoxoside-3'''''',4''''''-cyclic carbonate.
Claim 7
Dependent Claim
32 words
A compound according to claim 1, wherein the 3'''''',4''''''-acetal carbonyl moiety is that from a carbonyl compound selected from the group consisting of formaldehyde, acetaldehyde, benzaldehyde, acetone, methyl ethyl ketone and cyclohexanone.
Claim 8
Dependent Claim
19 words
A compound according to claim 6, that is 17 Beta -(3-furyl)-5 Beta ,14 Beta -androstane-3 Beta ,14,16 Beta -triol-3-tridigitoxoside-3'''''',4''''''-acetonide.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-10-21 | 1978-04-22 | 1978-10-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-10-21 | 1982-04-22 | 1982-10-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-10-21 | 1986-04-22 | 1986-10-22 | $7700.00 | Window Closed / Lapsed |