Patent US3839743A successfully refreshed from Google Patents.
US3839743A
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Method for maintaining the normal integrity of blood
Assignee: Individual
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Filing: 1973-10-15
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Granted: 1974-10-08
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Expires: 1993-10-15
Abstract
Abstract Thromboresistant biomedical articles are provided which are useful in the fields of subdermal surgical implants, laboratory apparatus and blood containers. These articles have at least a thin surface coating of an organic polymeric material having fluoroalkyl side chains and simple anionic side groups.
Inventors
- 👤 A Schwarcz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 08:30
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/0077; A61F2/02; A61F2/04; A61F2/06; A61K; A61K6/00; A61K6/80; A61K6/884; A61K6/887; A61L; A61L33/00; A61L33/06; A61L33/064; A61L33/066; Y; Y10; Y10T; Y10T428/00; Y10T428/31504; Y10T428/3154
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
118 words
A METHOD OR MAINTAINING THE NORMAL INTEGRITY OF BLOOD WHICH COMPRISES PLACING IT IN CONTACT WITH A PHYSIOLOGICALLY ACCEPTABLE ARTICLE AT LEAST THE SURFACE OF WHICH CONSISTS OF AN ORGANIC POLYMERIC MATERIAL HAING FLUOROALKYL SIDE CHAINS OF THE FORMULA CNF2N+1CMH2M-, WHHEREIN N AND M ARE INTEGERS, N RANGING 1 TO 28, AND THE SUM OF N AND M FROM 2 TO 28, THE NUMBER OF SAID FLUOROALKYL SIDE CHAINS RELATIVE TO THE NUMBER OF MAIN CHAIN ATOMS IN ONE RECURRING UNIT RANGES FROM 1:2 TO 1:10, AND SAID POLYMERIC MATERIAL HAVING ANOTHER SIDE GROUP CHEMICALLY BONDED TO THE MAIN CHAIN, SAID SIDE GROUP BEING SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, HALOGEN, ARYL, LOWER ALKYL AND ANIONIC GROUPS.
Claim 2
Independent Claim
118 words
A METHOD OR MAINTAINING THE NORMAL INTEGRITY OF BLOOD WHICH COMPRISES PLACING IT IN CONTACT WITH A PHYSIOLOGICALLY ACCEPTABLE ARTICLE AT LEAST THE SURFACE OF WHICH CONSISTS OF AN ORGANIC POLYMERIC MATERIAL HAING FLUOROALKYL SIDE CHAINS OF THE FORMULA CNF2N+1CMH2M-, WHHEREIN N AND M ARE INTEGERS, N RANGING 1 TO 28, AND THE SUM OF N AND M FROM 2 TO 28, THE NUMBER OF SAID FLUOROALKYL SIDE CHAINS RELATIVE TO THE NUMBER OF MAIN CHAIN ATOMS IN ONE RECURRING UNIT RANGES FROM 1:2 TO 1:10, AND SAID POLYMERIC MATERIAL HAVING ANOTHER SIDE GROUP CHEMICALLY BONDED TO THE MAIN CHAIN, SAID SIDE GROUP BEING SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, HALOGEN, ARYL, LOWER ALKYL AND ANIONIC GROUPS.
Claim 3
Dependent Claim
36 words
The method defined in claim 1 wherein the said fluoroalkyl side chains are linear, the said integers n and m range from 8 to 28 and the sum of n and m from 8 to 28.
Claim 4
Dependent Claim
35 words
The method defined in claim 1 wherein the said integer n ranges from 1 to 7, the sum of n and m from 2 to 28 and the said side group is an anionic group.
Claim 5
Dependent Claim
35 words
The method defined in claim 1 wherein said physiological acceptable article comprises a substrate portion and a surface coating portion, said surface coating portion at least being of said polymeric material defined in claim 1.
Claim 6
Dependent Claim
37 words
The method defined in claim 1 wherein the said anionic group is a member selected from the group consisting of the acid form of a carboxylate, sulfonate, sulfate, phosphate, phosphite and the salt forms of these groups.
Claim 7
Dependent Claim
31 words
The method defined in claim 1 wherein the ratio of the number of said fluoroalkyl side chains to the number of said anions is in the range of 1:1 to 20:1.
Claim 8
Independent Claim
29 words
The method defined in laim 1 wherein the said fluoroalkyl side chain is bonded to the main chain of the said organic polymeric material by an intermediate divaLent radical.
Claim 9
Independent Claim
29 words
The method defined in laim 1 wherein the said fluoroalkyl side chain is bonded to the main chain of the said organic polymeric material by an intermediate divaLent radical.
Claim 10
Dependent Claim
24 words
The method defined in claim 1 wherein the said anionic group is bonded to the said organic polymeric material by an intermediate divalent radical.
Claim 11
Dependent Claim
34 words
The method defined in claim 7 wherein the said intermediate divalent radical is a member selected from the group consisting of -O-, -CO-, -SO-, -SO2-, -SO2NH-, -CH2O-, -COO-, -NHCO-, -NHCONH-, -POCH3-, -POC2H5-, -SO2NCH3-, -SO2NC2H5-.
Claim 12
Dependent Claim
28 words
The method defined in claim 8 wherein the said intermediate divalent radical is a member selected from the group consisting of -CH2-, -C2H4-, -OC2H4-, -(CH2)8-, -(CF2)15-, -SO2NHChd 2H4-.
Claim 13
Dependent Claim
16 words
The method defined in claim 1 wherein said physiologically acceptable article is a subdermal surgical implant.
Claim 14
Dependent Claim
15 words
The method defined in claim 1 wherein said physiologically acceptable article is a surgical instrument.
Claim 15
Dependent Claim
19 words
The method defined in claim 1 wherein said physiologically acceptable article is a laboratory apparatus used for handling blood.
Claim 16
Dependent Claim
15 words
The method defined in claim 1 wherein said physiologically acceptable article is a blood container.
Claim 17
Dependent Claim
24 words
The method defined in claim 4 wherein the said substrate portion is selected from the group consisting of plastics, rubbers, metals, glass and ceramics.
Claim 18
Dependent Claim
39 words
The method defined in claim 1 wherein said organic polymeric material is selected from the group consisting of copolymers prepared from a fluoroalkyl acrylate and acrylic acid, a fluoroalkyl methacrylate and methacrylic acid and the mixtures of these monomers.
Claim 19
Dependent Claim
44 words
The method defined in claim 16 wherein said polymeric acrylates are selected from the group consisting of: poly(1,1- dihydropentacosafluorotridecyl acrylate) poly(1,1-dihydropentatetracontafluorotricosyl methacrylate) polyco(1,1-dihydropentadecafluorooctyl methacrylate - 10% sodium acrylate) polyco(1,1,2,2-tetrahydrotrifluoropropyl acrylate - 5% maleic acid) polyco(1,1,2,2-tetrahydropentadecafluorononyl acrylate - 30% methacrylic acid - 15% sodium methacrylate)
Claim 20
Dependent Claim
41 words
The method defined in claim 1 wherein said organic polymeric material is selected from the group consisting of: poly(methyl-1,1,2,2-tetrahydrotriacontafluorooctadecyl siloxane) poly(di(1,1,2,2-tetrahydrotricosafluorotridecyl) siloxane). poly(carboxyethyl-1,1,2,2-tetrahydrotrifluoropropyl siloxane) and poly(methyl-3,3,3- trifluoropropyl siloxane) wherein a minor part of the methyl groups is replaced with carboxyethyl groups.
Claim 21
Dependent Claim
73 words
The method defined in claim 1 wherein said organic polymeric material is selected from the group consisting of: polymers of fluoroalkyl esters, amides and imides of maleic and fumaric acids, the copolymers with ethylene, styrene, methylvinyl ether and vinyl acetate of fluoroalkyl esters, amides and imides of maleic and fumaric acids, the copolymers with maleic, fumaric and acrylic acids and their anhydrides of fluoroalkyl esters, amides and imides of maleic and fumaric acids.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-10-07 | 1978-04-08 | 1978-10-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-10-07 | 1982-04-08 | 1982-10-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-10-07 | 1986-04-08 | 1986-10-08 | $7700.00 | Window Closed / Lapsed |