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US3839155A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Cell and vaccine production
Assignee: Merck and Co Inc
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Filing: 1972-07-27
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Granted: 1974-10-01
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Expires: 1992-07-27
Abstract
Abstract Use of tumbling in a rotating disc propagator to evenly distribute the cell slurry, obtain two side plating of cells, increase the cell concentration and recover the cells from the propagator in small volumes of medium, whereby the overall yield of cells and vaccines is significantly increased and at substantially reduced costs as compared to presently utilized procedures.
Inventors
- 👤 Aleer W Mc
- 👤 R Spier
- 👤 K Posch
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 13:17
CPC Classifications
C; C12; C12N; C12N7/00; C12M; C12M25/00; C12M25/06; C12M27/00; C12M27/10; C12M27/14; C12N3/00; C12N2760/00; C12N2760/00011; C12N2760/18011; C12N2760/18711; C12N2760/18751
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
103 words
A DEVICE FOR USE IN THE PRODUCTION OF AT LEAST ONE MEMBER SELECTED FROM THE GROUP CONSISTING OF CELLS AND VACCINES WHICH COMPRISES; A MULTIPLATE PROPAGATOR COMPRISING A SUBSTANTIALLY CYLINDRICAL VESSEL HAVING TWO END PLATES IN WHICH THE DESIRED CELLS AND VACCINES ARE GROWN; A PLURALITY OF SPACED APART DISCS THAT ARE LOCATED WITHIN THE SAID PROPAGATOR AND ARE POSITIONED IN PLANES PARALLEL TO THE END PLATES OF SAID PROGATOR AND ARE ROTATIVELY MOUNTED ON A SHAFT THAT IS POSITIONED IN THE CENTER OF EACH OF SAID END PLATES; MEANS FOR HOLDING THE PROPAGATOR; AND MEANS FOR TUMBLING SAID PROPAGOTOR END OVER END.
Claim 2
Independent Claim
103 words
A DEVICE FOR USE IN THE PRODUCTION OF AT LEAST ONE MEMBER SELECTED FROM THE GROUP CONSISTING OF CELLS AND VACCINES WHICH COMPRISES; A MULTIPLATE PROPAGATOR COMPRISING A SUBSTANTIALLY CYLINDRICAL VESSEL HAVING TWO END PLATES IN WHICH THE DESIRED CELLS AND VACCINES ARE GROWN; A PLURALITY OF SPACED APART DISCS THAT ARE LOCATED WITHIN THE SAID PROPAGATOR AND ARE POSITIONED IN PLANES PARALLEL TO THE END PLATES OF SAID PROGATOR AND ARE ROTATIVELY MOUNTED ON A SHAFT THAT IS POSITIONED IN THE CENTER OF EACH OF SAID END PLATES; MEANS FOR HOLDING THE PROPAGATOR; AND MEANS FOR TUMBLING SAID PROPAGOTOR END OVER END.
Claim 3
Dependent Claim
18 words
A device as in claim 1 which further comprises means to control the tumbling speed of the propagator.
Claim 4
Dependent Claim
29 words
A device as in claim 1 wherein the tumbling means include a chain driven sprocket wheel which is engaged by an arm on said means for holding the propagator.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-09-30 | 1978-04-01 | 1978-10-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-09-30 | 1982-04-01 | 1982-10-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-09-30 | 1986-04-01 | 1986-10-01 | $7700.00 | Window Closed / Lapsed |