Production of stable,nonhydrous,homogeneous,in natural and mineral oils soluble vitamin-e-active cream-base-co-esters of the mineral-oil-insoluble d-alpha-tocopheryl-acid-succinate with anhydrous oils

Abstract

Abstract THE INVENTION CONCERNS A METHOD FOR PREPARING STABLE, NONHYDROUS HOMOGENEOUS, IN NATURAL AND MINERAL OILS SOLUBLE VITAMIN-E-ACTIVE CREAM-BASE-CO-ESTERS OF THE MINERAL-OIL-INSOLUBLE D-ALPHA-TOCOPHERYL-ACID-SUCCINATE WITH ANYDROUS OILS BY THE DIRECT ESTERIFICATION REACTION BETWEEN THE SAID D-ALPHA-TOCOPHERYL-ACID-SUCCINATE AND THE ANHYDROUS OILS OR, IN A MODIFICATION THEREOF, BY THE SAID DIRECT ESTERIFICATION REACTION BETWEEN THE D-ALPHA-TOCOPHERYL-ACID-SUCCINATE, MAGNESIUM STEARATE AS A PARTIAL SUBSTITUENT FOR THE EXPENSIVE D-ALPHA-TOCOPHERYL-ACID-SUCCINATE AND THE ANHYDROUS OILS, CARRIED TO COMPLETION BY THE APPLICATION OF GRADUALLY INCREASING REACTION TEMPERATURES TO THE REACTION MIXTURE CONSISTING OF THE SAID D-ALPHA-TOCOPHERYL-ACID-SUCCINATE, WITH OR WITHOUT ITS PARTIAL SUBSTITUENT MAGNESIUM STERATE, AND THE ANHYDROUS OILS LACKING BOTH IN PRACTICAL WATER ABSORPTION CAPACITIES AND THEREFORE FACILITATING WATER FORMED IN THE REACTION TO VAPORIZE AS THE ESTERIFICATION REACTION GOES TO COMPLETION FORMING THEREBY THE STABLE, NONHYDROUS, HOMOGENEOUS AND IN NATURAL AND MINERAL OILS SOLUBLE VITAMIN-E-ACTIVE CREAM-BASE-CO-ESTERS OF D-ALPHA-TOCOPHERYL-ACID-SUCCINATE WITH ANHYDROUS OILS AS ARE EXCELLENTLY SUITED FOR VERSATILE ADDITIONS OF VITAMIN-E-ACTIVE POTENCIES TO A WIDE VARIETY OF TOPICAL NATURAL AS WELL AS MINERAL OIL BASE PREPARATIONS FOR THE READY INTROUDUCTION THEREIN OF A WIDE RANGE OF VITAMIN E POTENCIES FROM AS LOW AS 25 I.U. TO AS MUCH AS ABOUT 726 I.U. VITAMIN E, WITHOUT REQUIRING THE USE OF EMULSIFYING AGENTS, OR WHICH MAY BE USED AS IS IN THEIR CREAMY CREAM-BASE-CO-ESTER FORM, PER SE.

Inventors

• 👤 G Ahrens

Bibliographic Details