N-carboxymethyl-n-substituted glycinate esters of 3-hydroxy-1,4-benzo-diazepin-2-ones
Abstract
Abstract THIS INVENTION IS DIRECTED TOWARD NOVEL CENTRAL NERVOUS SYSTEM DEPRESSANTS OF THE FORMULA: 1-R1,3-(R3O-CO-CH2-N(-R2)-CH2-CO-O-),5-(X-PHENYL),7-X-1,4- BENZODIAZEPIN-2-ONE WHEREIN R1 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF THE HYDROGEN, LOWER ALKYL, BENZYL AND LOWE ALKOXYALKYL RADICALS; R2 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF THE LOWER ALKYL, PHENYL AND BENYL RADICALS; R3 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, AN ALKALI METAL CATION, AN ALKALINE EARTH OF METAL CATION, THE AMMONIUM CATION, A TRI(LOWER)ALKYL AMMONIUM CATION, THE PYRIDINUM ION, A LOWER ALKYL RADICAL AND AN ARALKYL RADICAL OF 7 TO 9 CARBON ATOMS; X IS A MEMBER SELECTED FROM THE GROUP CONSISITNG OF THE HALO, CYANO, TRIFFUOROMETHYL, NITRO AND LOWER ALKYLTHIO RADICALS; Y IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF THE HYDROGEN, HALO, TRIFLUOROMETHYL, NITRO AND LOWER ALKYLTHIO RADICALS; AND THE PHARMACEUTICALLY ACCEPTABLE NACID ADDITION SALTS THEREOF. THIS INVENTION ALSO PROVIDES METHODS FOR THE PREPARATION OF THE CENTRAL NERVOUS SYSTEM DEPRESSANT COMPOUNDS AND THEIR ADMINISTRATION AS WELL AS THE COMPOSITIONS FOR ADMINISTRATION WHICH CONTAIN THE ACTIVE COMPOUNDS OF THIS INVENTION.
Inventors
- 👤 A Nudelman
- 👤 Caully R Mc
Bibliographic Details
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