Patent US3816076A successfully refreshed from Google Patents.
US3816076A
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Process for the determination of thyroxine
Assignee: Merck Patent GmbH
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Filing: 1972-06-09
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Granted: 1974-06-11
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Expires: 1992-06-09
Abstract
Abstract Method for the determination of thyroxine in biological fluids by adsorption on a cation exchanger, subsequent washing out of the interfering components, eluting the adsorbed thyroxine, liberating the iodine therefrom, and then carrying out the iodine determination in a conventional manner, which process is characterized by the use of an eluent, optionally together with a basic buffer, which destroys amino groups and liberates iodine from the thyroxine into the eluate.
Inventors
- 👤 E Backer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 04:54
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/74; G01N33/78; Y; Y10; Y10S; Y10S436/00; Y10S436/825; Y10S436/826
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
13 words
A process according to claim 1 wherein the eluent comprises a basic buffer.
Claim 2
Dependent Claim
17 words
A process according to claim 1 wherein the eluent comprises a solution of a hypobromite or hypochlorite.
Claim 3
Dependent Claim
13 words
A process according to claim 3 wherein the eluent comprises a basic buffer.
Claim 4
Dependent Claim
13 words
A process according to claim 4 wherein the buffer is a borate buffer.
Claim 5
Dependent Claim
15 words
A process according to claim 3 wherein the eluent comprises sodium hypobromite or sodium hypochlorite.
Claim 6
Dependent Claim
17 words
A process according to claim 3 wherein the molarity of the hypobromite solution is 0.0075 - 0.02M.
Claim 7
Dependent Claim
12 words
A process according to claim 7 wherein the molarity is about 0.015M.
Claim 8
Dependent Claim
11 words
A process according to claim 1 wherein the eluate is heated.
Claim 9
Dependent Claim
21 words
A process according to claim 1 wherein an iodine determination of the eluate is conducted photometrically, employing the cerium(IV) arsenite reaction.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-06-10 | 1977-12-10 | 1978-06-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-06-10 | 1981-12-10 | 1982-06-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-06-10 | 1985-12-10 | 1986-06-11 | $7700.00 | Window Closed / Lapsed |