Catalyzed radioiodine exchange
Abstract
Abstract ISOTOPIC EXCHANGE BETWEEN RADIODINE ATOMS IN AN IODIDE SALT AND STABLE IODINE ATOMS BOUND TO AROMATIC CARBON SALT AND STABLE IODINE ATOMS BOUND TO AROMATIC AMOUNTS OF COPPER, FOR EXAMPLE, BY 2.3X10**4MG. OF CUPRIC SULFATE PER MG. OF ORGANIC COMPOUND. THE PRESENCE OF SMALL AMOUNTS OF WATER IN THE REACTION MEDIUM FURTHER ENHANCES THE EFFECT OF COPPER. NOT ONLY IS THE CONVERSION OF STBLE IODINATED COMPOUNDS TO THEIR RADIOODINATED ISO MERS SUBSTANTIALLY INCREASED IN MANY CASES, BUT ALSO LOWER TEMPERATURES AND SHORTER REACTION TIMES ARE FEASIBLE WITH LESS RISK OF DAMAGE TO HEAT-SENSITIVE ORGANIC COMPOUNDS THEREBY BROADENING THE RANGE OF USEFUL RADIOIODINATED COMPOUNDS WHICH CAN BE PREPARED BY ISOTOPE EXCHANGE. EXEMPLIFIED ARE QUINOLINES, TRYPTOPHANS, BENZOIC AND IOCETAMIC ACIDS.
Inventors
- 👤 G Hoey
- 👤 D Peckels
- 👤 P Wiegert
Bibliographic Details
Claims Analysis
Total Claims: 0References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1977-06-03 | 1977-12-03 | 1978-06-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-06-03 | 1981-12-03 | 1982-06-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-06-03 | 1985-12-03 | 1986-06-04 | $7700.00 | Window Closed / Lapsed |