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US3810473A
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Liquid-laid, non-woven, fibrous collagen derived surgical web having hemostatic and wound sealing properties
Assignee: Alcon Puerto Rico Inc
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Filing: 1972-12-04
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Granted: 1974-05-14
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Expires: 1992-12-04
Abstract
Abstract Liquid-laid, non-woven, fibrous web having hemostatic and adhesive properties sufficient to seal a wound formed of fibers of ionizable, water-insoluble, partial acid salts of collagen, the web having certain specified absorbency and porosity characteristics. In order to prevent excessive swelling of the fibers with resulting excessive hornification or densification upon drying, it is essential that mixtures of water-miscible organic liquids such as ethanol with specified minor porportions of water be utilized as the slurrying media.
Inventors
- 👤 M Cruz
- 👤 C Cirolla
- 👤 O Battista
- 👤 L Tressler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:17
CPC Classifications
A; A61; A61F; A61F13/00; A61F13/02; A61F13/0276; A61F13/0289; A61F13/01; A61F13/01034; A61F13/0203; A61F13/0223; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/32; A61L15/325; A61L15/42; A61L15/58; A61F13/15; A61F13/84; A61F13/8405; A61F2013/00089; A61F2013/00217; A61F2013/00221; A61F2013/00361; A61F2013/00365; A61F2013/00463; A61F2013/00472; A61F2013/00727; A61F2013/00731; A61F2013/00744; A61F13/15577; A61F2013/15821; A61L2400/00; A61L2400/04; Y; Y10; Y10S; Y10S128/00; Y10S128/08
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
36 words
A dressing as defined in claim 1 wherein the web has a Stiffness Factor of from about 15* to about 100* based upon a web having a basis weight of about 175.5 lbs. per 3,000 sq.ft.
Claim 2
Dependent Claim
17 words
A dressing as defined in claim 1 wherein the fibers are partial hydrogen chloride salts of collagen.
Claim 3
Dependent Claim
32 words
A dressing as defined in claim 2 wherein the fibers are partial hydrogen chloride salts of collagen containing from 60 percent to 85 percent of the theoretical stoichiometric amount of hydrogen chloride.
Claim 4
Dependent Claim
72 words
A dressing as defined in claim 1 wherein the fibers have a fiber length distribution by the McNett Classifier such that about 45 to 55% are retained on a 20 mesh screen, 20 to 25% are retained on a 35 mesh screen, 3 to 6% are retained on a 65 mesh screen, 0.5 to 1.5% are retained on a 150 mesh screen, and not more than 30% pass a 150 mesh screen.
Claim 5
Dependent Claim
88 words
A dressing as defined in claim 2 wherein the fibers are partial hydrogen chloride salts of collagen containing from 60% to 85% of the theoretical stoichiometric amount of hydrogen chloride and the fibers have a fiber length distribution by the McNett Classifier such that about 48% are retained on a 20 mesh screen, about 22% are retained on a 35 mesh Screen, about 3.6% are retained on a 65 mesh screen, about 0.7% are retained on a 150 mesh screen and the balance passes a 150 mesh screen.
Claim 6
Independent Claim
112 words
The method of forming a hemostatic adhesive liquid-laid, non-woven web dressing for severed biological surfaces from hemostatic-adhesive fibers of ionizable, water-insoluble, partial acid salts of collagen including the steps of slurrying the fibers in a mixture of a water-miscible organic liquid and water, sheeting the fibers to form a web and drying the web, the fibers of the partial acid salt of collagen containing from about 50% to about 90% of the theoretical stoichiometric amount of ionizable acid, the mixture of organic liquid and water consisting of from about 95 volumes of organic liquid and about 5 volumes of water to about 80 volumes of organic liquid and 20 volumes of water.
Claim 7
Dependent Claim
72 words
The method as defined in claim 7 wherein the fibers have a fiber length distribution by the McNett Classifier such that about 45 to 55% are retained on a 20 mesh screen, 20 to 25% are retained on a 35 mesh screen, 3 to 6% are retained on a 65 mesh screen, 0.5 to 1.5% are retained on a 150 mesh screen, and not more than 30% pass a 150 mesh screen.
Claim 8
Dependent Claim
13 words
The method as defined in claim 7 wherein the organic liquid is ethanol.
Claim 9
Dependent Claim
42 words
The method as defined in claim 7 wherein the mixture consists of from about 95 volumes of ethanol and about 5 volumes of water to about 80 volumes of ethanol and about 20 volumes of water and the web is freeze dried.
Claim 10
Dependent Claim
42 words
The method as defined in claim 7 wherein the mixture consists of from about 95 volumes of ethanol and about 5 volumes of water to about 85 volumes of ethanol and about 15 volumes of water and the web is vacuum dried.
Claim 11
Dependent Claim
106 words
The method as defined in claim 7 wherein the fibers of the partial acid salt of collagen contain from 60% to 85% of the theoretical stoichiometric amount of hydrogen chloride, the mixture consists of 90 volumes of ethanol and 10 volumes of water, the fibers have a fiber length distribution by the McNett Classifier such that about 48% are retained on a 20 mesh screen, about 22% are retained on a 35 mesh screen, about 3.6% are retained on a 65 mesh screen, about 0.7% are retained on a 150 mesh screen and the balance passes a 150 mesh screen and the web is freeze dried.
Claim 12
Independent Claim
179 words
The method of joining severed biological surfaces in a living warm blooded animal which comprises placing between and in contact with the severed surfaces a liquid-laid, non-woven fibrous web of hemostatic-adhesive fibers of ionizable, water-insoluble, partial acid salts of collagen, allowing the web to become wetted with blood, pressing the web into contact with the severed surfaces until hemostasis has been effected and then releasing the pressure, the web having the property of combining with blood to effect hemostasis and to form a mass with the blood that is self-adherent to the severed surfaces and thereby seal the wound, the web having an absorbency of a mixture of 90 volumes of ethanol and 10 volumes of water of between about 100% and 300% by weight and having a porosity of from about 4 to about 15 seconds per 6.45 sq.cm. based upon a web having a basis weight of about 175.5 lbs. per 3,000 sq.ft., the fibers of the partial acid salt of collagen containing from about 50% to about 90% of the theoretical stoichiometric amount of ionizable acid.
References Cited (Backward Citations)
US3438374A
Cited
US3742955A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-05-13 | 1977-11-12 | 1978-05-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-05-13 | 1981-11-12 | 1982-05-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-05-13 | 1985-11-12 | 1986-05-14 | $7700.00 | Window Closed / Lapsed |