Analogues of human thyrocalcitonin modified with corresponding amino acids of salmon thyrocalcitonin and derivatives thereof
Abstract
Abstract HYPOCALCAEMIC PEPTIDE AMIDES OF THE FORMULA H-CYS-GLY-ASN-LEU-SER-THR-CYS-X-LEU-GLY-THR-TYR-THR-GLNASP-PHE-ASN-LYS-PHE -HIS-THR-PHE-PRO-GLN-THR-ALA-ILEGLY-VAL-GLY-ALA-PRO-NH2, WHERE THE CYS RESIDUES ARE JOINED. WHEREIN X REPRESENTS THE RADICAL OF L-METHIONINE, L-VALINE, L-NORVALINE, L-LEUCINE, L-ISOLEUCINE, L-NORLEUCINE OR L-A-AMINOBUTYRIC ACID AND WHEREIN AT LEAST ONE OF THE AMINOACIDS IN POSITIONS 13, 12, 16, 17, 19, 20, 22 AND 24 IS REPLACED BY ANOTHER AMONOACID, NAMELY L-THREONINE11 BY L-LYSINE, L-TYROSINE12 BY L-LEUCINE, L-PHENYLALANINE16 BY L-LEUCINE, L-ASPARAGING17 BY L-HISTIDINE, L-PHENYLALANINE19 BY L-LEUCINE, L-HISTIDINE20 BY L-GLUTAMINE, LPHENYLALANINE22 BY L-TYROSINE AND L-GLUTAMINE24 BY L-ARGININE.
Inventors
- 👤 M Brugger
- 👤 B Riniker
- 👤 W Rittel
Bibliographic Details
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