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US3797492A Expired / Lapsed US ⏱️ 0.0 years remaining

Device for dispensing product with directional guidance member

Assignee: Alza Corp
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Filing: 1972-12-27
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Granted: 1974-03-19
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Expires: 1992-12-27
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Abstract

Abstract A drug product dispensing device is comprised of a product compartment having a metering means for dispensing its product in a body cavity, and a propellant compartment communicating with the product compartment for producing a propellant. In one embodiment, a self actuated valve is positioned between the product and the propellant compartment for directing the flow of propellant into the product compartment. In another embodiment, a slidable piston is positioned in the product compartment for receiving the flow of propellant moving into the product compartment. A collapsed bag is joined to the propellant compartment with the bag capable of being inflated by a propellant from the propellant compartment to maintain the device in a product receptive area. The device is optionally housed in a bioerodible container and released therefrom prior to its dispensing a product. In both embodiments of the device, product is moved through the metering means by propellant either moving through the valves or against the piston to urge product through the means.

Inventors

  • 👤 V Place

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-05 15:11
CPC Classifications
A; A61; A61M; A61M31/00; A61M31/002; A61K; A61K9/00; A61K9/0002; A61K9/0004; A61M37/00

Claims Analysis

Total Claims: 15
Claim 1
Independent Claim 269 words
A drug type product delivery device for the continuous administration of a product, said device comprising, a. a wall surrounding an internal space, the space housing, b. a product compartment which serves as a reservoir for containing a beneficial product with the product compartment adjacent to, c. a propellant compartment which serves as a means for containing an agent for producing a gas having a vapor pressure above one atmosphere at the temperature of product administration, d. a valve between the compartments for directing the flow of a gas from the propellant compartment to the product compartment, e. a discharge metering means communicating with the product chamber and the exterior of the device for metering a product at a controlled and continuous rate from the product chamber, f. a hollow deformable member comprised of a flexible distendable material joined to the propellant compartment, g. the hollow deformable member freely movable from a collapsed position to an expanded position and movable from an expanded position to a collapsed position after a period of time, h. and wherein the device when positioned in the environment of use, the deformable member is moved from a collapsed to an expanded position by gas produced in the propellant compartment that moves into the deformable member and on release of the gas therefrom it subsequently returns to a collapsed position and while in the environment of use and when charged with product, said product is metered through the discharge means on movement of gas through the valve into the product compartment to continuously move a therapeutically effective amount of product from the product delivery device.
Claim 2
Dependent Claim 269 words
A drug type product delivery device for the continuous administration of a product, said device comprising, a. a wall surrounding an internal space, the space housing, b. a product compartment which serves as a reservoir for containing a beneficial product with the product compartment adjacent to, c. a propellant compartment which serves as a means for containing an agent for producing a gas having a vapor pressure above one atmosphere at the temperature of product administration, d. a valve between the compartments for directing the flow of a gas from the propellant compartment to the product compartment, e. a discharge metering means communicating with the product chamber and the exterior of the device for metering a product at a controlled and continuous rate from the product chamber, f. a hollow deformable member comprised of a flexible distendable material joined to the propellant compartment, g. the hollow deformable member freely movable from a collapsed position to an expanded position and movable from an expanded position to a collapsed position after a period of time, h. and wherein the device when positioned in the environment of use, the deformable member is moved from a collapsed to an expanded position by gas produced in the propellant compartment that moves into the deformable member and on release of the gas therefrom it subsequently returns to a collapsed position and while in the environment of use and when charged with product, said product is metered through the discharge means on movement of gas through the valve into the product compartment to continuously move a therapeutically effective amount of product from the product delivery device.
Claim 3
Dependent Claim 38 words
A product delivery device for the continuous administration of a product according to claim 1 wherein the hollow deformable member is provided with a bioerodible plug that on bioerosion vents the interior of the member to its exterior.
Claim 4
Dependent Claim 50 words
A product delivery device for the continuous administration of a product according to claim 1 wherein the hollow deformable member is formed of an elastic material perMeable to an inflating gas that slowly let the gas diffuse through the material to move the member from an expanded to collapsed position.
Claim 5
Dependent Claim 45 words
A product delivery device for the continuous administration of a product according to claim 1 wherein drug is metered through the discharge means in response to gas filling the product compartment to increase its volume while reducing the volume of drug in the product compartment.
Claim 6
Dependent Claim 26 words
A product delivery device for the continuous and controlled administration of a product according to Claim 1 wherein the device is contained in a bioerodible container.
Claim 7
Dependent Claim 31 words
A product delivery device for the continuous and controlled administration of a product according to claim 1 wherein a valve is positioned between the propellant compartment and the hollow deformable member.
Claim 8
Dependent Claim 264 words
A drug type delivery device for the continuous and controlled administration of a product for producing a beneficial effect, wherein the device comprises: a. a wall surrounding an internal space and formed of a material substantially impermeable to product, the space containing b. a reservoir compartment for containing a beneficial product, and c. a propellant compartment as a means for containing a chemical agent for producing a gas having a vapor pressure in excess of one atmosphere, at the temperature of product administration from the device, d. a piston slidably positioned between the reservoir compartment and the propellant compartment, the piston movable in response to gas produced in the propellant compartment, e. a metering means communicating with the reservoir and the exterior of the device for metering an effective amount of product at a controlled rate from the reservoir, f. a hollow deformable member comprised of a distendable material joined to the propellant compartment, g. the hollow deformable member movable from a collapsed to an expanded position and returnable to a collapsed position after a period of time, h. a passageway communicating with the propellant compartment and the deformable member, i. and wherein the device when positioned in the environment of use and when charged with product, the deformable member is inflated by gas flowing from the propellant compartment into the member, and product is urged through the metering means by the movement of the piston into the product compartment in response to gas produced in the propellant compartment to progressively decrease the volume of the reservoir as product is administered from the device.
Claim 9
Dependent Claim 264 words
A drug type delivery device for the continuous and controlled administration of a product for producing a beneficial effect, wherein the device comprises: a. a wall surrounding an internal space and formed of a material substantially impermeable to product, the space containing b. a reservoir compartment for containing a beneficial product, and c. a propellant compartment as a means for containing a chemical agent for producing a gas having a vapor pressure in excess of one atmosphere, at the temperature of product administration from the device, d. a piston slidably positioned between the reservoir compartment and the propellant compartment, the piston movable in response to gas produced in the propellant compartment, e. a metering means communicating with the reservoir and the exterior of the device for metering an effective amount of product at a controlled rate from the reservoir, f. a hollow deformable member comprised of a distendable material joined to the propellant compartment, g. the hollow deformable member movable from a collapsed to an expanded position and returnable to a collapsed position after a period of time, h. a passageway communicating with the propellant compartment and the deformable member, i. and wherein the device when positioned in the environment of use and when charged with product, the deformable member is inflated by gas flowing from the propellant compartment into the member, and product is urged through the metering means by the movement of the piston into the product compartment in response to gas produced in the propellant compartment to progressively decrease the volume of the reservoir as product is administered from the device.
Claim 10
Dependent Claim 46 words
A product delivery device for the continuous administration of a product according to claim 7 wherein the hollow deformable member is provided with a bioerodible plug that is capable of bioerosion in the environment of use to vent the interior of the member to its exterior.
Claim 11
Dependent Claim 49 words
A product delivery device for the continuous administration of a product according to claim 7 wherein the hollow deformable member is formed of an elastic material permeable to an inflating gas and slowly lets the gas diffuse through the material to move an expanded member to a collapsed member.
Claim 12
Dependent Claim 30 words
A product delivery device for the continuous administration of a product according to claim 7 wherein the product is a beneficial drug that can produce a local or systemic effect.
Claim 13
Dependent Claim 39 words
A product delivery device for the continuous administration of a product according to claim 7 wherein the device is contained in a bioerodible container formed of a material that can bioerode at a physiological temperature in a physiological environment.
Claim 14
Dependent Claim 31 words
A product delivery device for the continuous and controlled administration of a product according to claim 7 wherein a unidirectional valve is positioned between the propellant compartment and the deformable member.
Claim 15
Dependent Claim 38 words
A product delivery device for the continuous and controlled administration of a product according to claim 1 wherein the product delivery device is made of a material that can bioerode at biological temperatures over a perIod of time.

References Cited (Backward Citations)

US1957564A Cited
US2485235A Cited
US3604417A Cited
US3731681A Cited
US3692027A Cited
US3701351A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1977-03-18 1977-09-17 1978-03-19 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1981-03-18 1981-09-17 1982-03-19 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1985-03-18 1985-09-17 1986-03-19 $7700.00 Window Closed / Lapsed

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